Stephen Kennedy

ObjectiveTo investigate whether the eNOS gene influences the risk of developing endometriosis in south Indian women.Study designThe single nucleotide polymorphism, Glu298Asp, in exon7 of the eNOS gene was tested for association in a case-co…

BACKGROUND: Genetic variation contributes to the risk of developing endometriosis. This review summarizes gene mapping studies in endometriosis and the prospects of finding gene pathways contributing to disease using the latest genome-wide …

A patent has been granted to Inspire Pharmaceuticals for an invention that aims to increase vaginal and cervical secretions. A P2Y2 and/or P2Y4 purinergic receptor agonist will be administered at a dose that stimulates a woman’s own mucin p…

A US patent, granted to the Maruha Corporation and the Osaka Bioscience Institute, relates to pregnancy-induced hypertension. The patent describes a novel method to detect abnormalities that occur before the onset of pregnancy-induced hyper…

OBJECTIVE: We investigated a possible association between endometriosis and polymorphisms in the genes encoding epidermal growth factor (EGF) receptor (EGFR) and EGF in a Japanese population. METHODS: We compared the distribution of the Eg…

OBJECTIVES: Case-control studies have previously associated polymorphisms in the gene encoding the xenobiotic metabolizing enzyme arylamine N-acetyltransferase 2 (NAT2) with endometriosis, a common multifactorial disease in women. These stu…

ObjectiveTo determine the relationship between disease severity and patient characteristics in endometriosis.DesignCross-sectional study of self-reported survey data.SettingAcademic research setting.Patient(s)One thousand women in the Oxfor…

BACKGROUND: Endometriosis is a common gynaecological condition which affects many women of reproductive age worldwide and is a major cause of pain and infertility. The modern oral contraceptive pill is widely used to treat pain occurring as…

BACKGROUND: The aim of the study was to test whether the signal transducer and activator of transcription 6 (STAT6) gene influences the risk of developing endometriosis. METHODS: The single-nucleotide polymorphism, G2964A, in the 3'-untran…

OBJECTIVES: To report the short- and medium-term complications of laparoscopic laser excisional surgery for rectovaginal endometriosis. DESIGN: Retrospective cohort study. SETTING: University teaching hospital, UK. POPULATION: A total of 12…

Endometriosis has a genetic component, and significant linkage has been found to a region on chromosome 10q. Two candidate genes, EMX2 and PTEN, implicated in both endometriosis and endometrial cancer, lie on chromosome 10q. We hypothesized…

Endometriosis has a genetic component, and significant linkage has been found to a region on chromosome 10q. Two candidate genes, EMX2 and PTEN, implicated in both endometriosis and endometrial cancer, lie on chromosome 10q. We hypothesized…

BACKGROUND: Vascular endothelial growth factor (VEGF) concentration in endometriosis patients is higher than controls, in serum and ascites, suggesting that VEGF may play an important role in the pathogenesis of endometriosis. In this study…

OBJECTIVE: To describe the attitudes that women with chronic pelvic pain (CPP) attending gynaecology clinics have to their consultations and to determine the ways in which their health care can be improved. DESIGN: Qualitative study using s…

BACKGROUND: To test the data quality, scaling assumptions and scoring algorithms underlying the Endometriosis Health Profile-30 (EHP-30) questionnaire: a questionnaire developed to measure the health-related quality of life (HRQoL) of women…

Histopathology and epidemiology studies have consistently demonstrated a strong link between endometriosis and endometriosis-associated ovarian cancers (EAOCs)--in particular, the endometrioid and clear cell subtypes. However, it is still u…

Chronic pelvic pain (CPP) is common, affecting approximately one in six of the adult female population (1) and can have devastating social and economic consequences. Pain which is very severe even if infrequent may make it difficult to hold…

A tool is needed to enable clinicians to determine whether women wish to seek a pathology-based explanation for chronic pelvic pain or whether they just want symptom relief. Such an approach might reduce the number of unnecessary laparoscop…

BACKGROUND: Endometriosis is a common disease with a heritable component. The collaborative International Endogene Study consists of two data sets (Oxford and Australia) comprising 1176 families with multiple affected. The aim was to invest…

ObjectiveTo evaluate the phenotype, proliferative, and differentiation capacities in vitro of stromal cells derived from peritoneal, ovarian, and deeply infiltrating endometriosis.DesignExperimental study using phase contrast microscopy, im…

ObjectiveTo identify consistent genetic changes in endometriosis samples to determine whether endometriosis lesions are true neoplasms.DesignWe analyzed ovarian endometriosis lesions for loss of heterozygosity (LOH) at 12 loci of potential …

ObjectiveEndometriosis is an immune-related, chronic inflammatory disease with polygenic predisposition. Cell adhesion molecules are expressed in endometriotic lesions, and in cells and tissues that are involved in the development and progr…

OBJECTIVE: Endometriosis is an immune-related, chronic inflammatory disease with polygenic predis-position. Cell adhesion molecules are expressed in endometriotic lesions, and in cells and tissues that are involved in the development and pr…