Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in a Japanese population

Mieko Inagaki, Shigeki Yoshida, Yoshida S, Kennedy S, Stephen Kennedy, Naoya Takemura, Takemura N, Deguchi M, Masashi Deguchi, Ohara N, Noriyuki Ohara, Takeshi Maruo, Maruo T
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2007 · doi:10.1080/09513590701521057 · PMID:17852426
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This study found no association between epidermal growth factor receptor and epidermal growth factor gene polymorphisms and endometriosis risk in a Japanese population.

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Abstract

OBJECTIVE: We investigated a possible association between endometriosis and polymorphisms in the genes encoding epidermal growth factor (EGF) receptor (EGFR) and EGF in a Japanese population. METHODS: We compared the distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms by polymerase chain reaction-restriction fragment length polymorphism analysis in 146 affected women and 181 controls. RESULTS: No significant differences in the frequency and genotype distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms were found between endometriosis patients with all disease stages and controls. Stratification by disease stage had no effect on the results. CONCLUSION: The Egfr+2073 A/T and Egf+61 G/A polymorphisms are not associated with an increased risk of endometriosis in a Japanese population.
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Kobe University Repository : Kernel PDF issue: 2026-07-17 Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in　a Japanese population (Degree) 博士（医学） (Date of Degree) 2007-11-14 (Resource Type) doctoral thesis (Report Number) 乙2963 (URL) https://hdl.handle.net/20.500.14094/D2002963 ※ 当コンテンツは神戸大学の学術成果です。無断複製・不正使用等を禁じます。著作権法で認められている範囲内で、適切にご利用ください。 稲垣, 美恵子 氏名 稲垣 美恵子 博士の専攻分野の名称 博士（医学） 学位記番号 博ろ第 2020 号 学位授与の 要件 学位規則第 5 条第 2 項該当 学位授与の 日付 平成 19年 11月 14日 審査委員 主査 教 授 松尾 雅文 教 授 西尾 久英 教 授 藤澤 正人 【 学位論文題目 】 Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in a Japanese population（子宮内膜症における epidermal growth factor(EGF)ならびに EGF receptor(EGFR)遺伝子多型の解析） —^Ql•‹

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Epidermal Growth Factor ErbB Receptors Adult Amplified Fragment Length Polymorphism Analysis Asian People Asian People Chi-Square Distribution Endometriosis Epidermal Growth Factor ErbB Receptors Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Infant, Newborn Japan Odds Ratio Polymorphism, Restriction Fragment Length

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europepmc
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pubmed
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