Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in a Japanese population

Mieko Inagaki, Shigeki Yoshida, Yoshida S, Kennedy S, Stephen Kennedy, Naoya Takemura, Takemura N, Deguchi M, Masashi Deguchi, Ohara N, Noriyuki Ohara, Takeshi Maruo, Maruo T
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2007 · doi:10.1080/09513590701521057 · PMID:17852426
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This study found no association between epidermal growth factor receptor and epidermal growth factor gene polymorphisms and endometriosis risk in a Japanese population.

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This doctoral thesis investigates the potential association between polymorphisms in the epidermal growth factor receptor and epidermal growth factor genes and the development of endometriosis within a Japanese population. The study analyzes genetic variations to determine if specific alleles contribute to disease susceptibility or progression among the participants. Results indicate whether these genetic markers are significantly linked to the presence or severity of the condition in this demographic group. This paper is centrally about endometriosis, specifically examining the role of EGFR and EGF gene polymorphisms in its pathogenesis.

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Abstract

OBJECTIVE: We investigated a possible association between endometriosis and polymorphisms in the genes encoding epidermal growth factor (EGF) receptor (EGFR) and EGF in a Japanese population. METHODS: We compared the distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms by polymerase chain reaction-restriction fragment length polymorphism analysis in 146 affected women and 181 controls. RESULTS: No significant differences in the frequency and genotype distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms were found between endometriosis patients with all disease stages and controls. Stratification by disease stage had no effect on the results. CONCLUSION: The Egfr+2073 A/T and Egf+61 G/A polymorphisms are not associated with an increased risk of endometriosis in a Japanese population.
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Kobe University Repository : Kernel PDF issue: 2026-07-17 Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in　a Japanese population (Degree) 博士（医学） (Date of Degree) 2007-11-14 (Resource Type) doctoral thesis (Report Number) 乙2963 (URL) https://hdl.handle.net/20.500.14094/D2002963 ※ 当コンテンツは神戸大学の学術成果です。無断複製・不正使用等を禁じます。著作権法で認められている範囲内で、適切にご利用ください。 稲垣, 美恵子 氏名 稲垣 美恵子 博士の専攻分野の名称 博士（医学） 学位記番号 博ろ第 2020 号 学位授与の 要件 学位規則第 5 条第 2 項該当 学位授与の 日付 平成 19年 11月 14日 審査委員 主査 教 授 松尾 雅文 教 授 西尾 久英 教 授 藤澤 正人 【 学位論文題目 】 Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in a Japanese population（子宮内膜症における epidermal growth factor(EGF)ならびに EGF receptor(EGFR)遺伝子多型の解析） —^Ql•‹

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Epidermal Growth Factor ErbB Receptors Adult Amplified Fragment Length Polymorphism Analysis Asian People Asian People Chi-Square Distribution Endometriosis Epidermal Growth Factor ErbB Receptors Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Infant, Newborn Japan Odds Ratio Polymorphism, Restriction Fragment Length

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