Sinreih M

No ORCID on file · 4 papers in corpus · active 2014-2023

Study types

  • article 1
  • other 1

Condition tags

  • endometriosis 2
other 2023
17β-Hydroxysteroid dehydrogenases types 1 and 2: Enzymatic assays based on radiometric and mass-spectrometric detection
Methods in enzymology ·doi:10.1016/bs.mie.2023.04.015

The 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) has a key role in estrogen biosynthesis as it catalyzes the reduction of estrone to the most potent estrogen, estradiol. Estradiol has a high affinity for estrogen receptors and thus sti…

2021
Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives.
Journal of enzyme inhibition and medicinal chemistry ·doi:10.1080/14756366.2021.1937142

Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. T…

2015
Combined liquid chromatography-tandem mass spectrometry analysis of progesterone metabolites.
PloS one ·doi:10.1371/journal.pone.0117984

Progesterone has a number of important functions throughout the human body. While the roles of progesterone are well known, the possible actions and implications of progesterone metabolites in different tissues remain to be determined. Ther…

article 2014
Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2α biosynthesis and action in ovarian endometriosis tissue and in model cell lines
Chemico-biological interactions ·doi:10.1016/j.cbi.2014.11.009

Endometriosis is a frequent benign gynecological disease characterized by endometrial tissue outside the uterine cavity. The estimated prevalence in the general population is 6-10%, but this reaches 30-50% in women with infertility and/or p…