Methods in enzymology
Methods Enzymol
· ISSN (e) 1557-7988
· 5 papers in corpus
other
2023
The 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) has a key role in estrogen biosynthesis as it catalyzes the reduction of estrone to the most potent estrogen, estradiol. Estradiol has a high affinity for estrogen receptors and thus sti…
review
2023
Cytochrome P450 aromatase (AROM) and steroid (estrone (E1)/dehydroepiandrosterone (DHEA)) sulfatase (STS) are the two key enzymes responsible for the biosynthesis of estrogens in human, and maintenance of the critical balance between androg…
2016
The most frequently occurring mutations in the gene encoding nuclear lamin A and nuclear lamin C cause striated muscle diseases virtually always involving the heart. In this review, we describe the approaches and methods used to discover th…
2009
Shortly after the recognition of the profound physiological significance of the pulsatile nature of hormone secretion, computer-based modeling techniques were introduced for the identification and characterization of such pulses. Whereas th…
other
2008
Angiogenesis is a key component in several major clinical conditions including cancer, diabetic retinopathy, rheumatoid arthritis, endometriosis and psoriasis. All these diseases could be managed much more effectively if their angiogenic ca…