Büdefeld T

ORCID: 0000-0002-0305-6494 · 3 papers in corpus
lab-animal 2026
Targeting Steroid-Metabolizing Enzymes with 15β-Substituted Estrone Analogues: Dual Discovery of AKR1C2/17β-HSD1 Inhibitors and a Fluorescent 17β-HSD1 Ligand
Cancers ·doi:10.3390/cancers18121889

BACKGROUND/OBJECTIVES: Aldo-keto reductase isoforms AKR1C1-3 and 17β-hydroxysteroid dehydrogenase 1 and 2 (17β-HSD1 and 17β-HSD2) are key enzymes in steroid metabolism and validated targets in hormone-dependent cancers. METHODS: In this st…

lab-animal 2021
Altered Profile of E1-S Transporters in Endometrial Cancer: Lower Protein Levels of ABCG2 and OSTβ and Up-Regulation of SLCO1B3 Expression
International journal of molecular sciences ·doi:10.3390/ijms22083819

Endometrial cancer (EC) is associated with increased estrogen actions. Locally, estrogens can be formed from estrone-sulphate (E1-S) after cellular uptake by organic anion-transporting polypeptides (OATP) or organic anion transporters (OAT)…

lab-animal 2021
Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
Journal of enzyme inhibition and medicinal chemistry ·doi:10.1080/14756366.2021.1937142

Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. T…