Izidor Sosič

ORCID: 0000-0002-3370-4587 · 2 papers in corpus

2015

Combined liquid chromatography-tandem mass spectrometry analysis of progesterone metabolites.

PloS one ·doi:10.1371/journal.pone.0117984

Progesterone has a number of important functions throughout the human body. While the roles of progesterone are well known, the possible actions and implications of progesterone metabolites in different tissues remain to be determined. Ther…

article 2012

Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins

The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2011.12.011

The human aldo-keto reductase AKR1C2 converts 5α-dihydrotestosterone to the less active 3α-androstanediol and has a minor 20-ketosteroid reductase activity that metabolises progesterone to 20α-hydroxyprogesterone. AKR1C2 is expressed in dif…