Joseph A. Hill

Objectives: Immunologic mechanisms are implicated in the pathogenesis of endometriosis and endometriosis-associated reproductive failure. The purpose of this study was to describe key immune response elements in eutopic and ectopic endometr…

ObjectiveTo determine whether peripheral blood mononuclear cell (PBMC) secretion of T-helper (Th)-1 type cytokines and Th-2 and Th-3 type cytokines in women undergoing in vitro fertilization-embryo transfer (IVF-ET) is associated with thera…

BACKGROUND: A key factor in the pathogenesis of endometriosis is the endometrial-peritoneal adhesion. To study the pathogenesis of endometriosis, a quantitative in vitro assay (QIVA) was developed to measure in vitro adhesion between human …

There are many arguments to support the hypothesis that there is a causal relationship between the presence of endometriosis and subfertility. These arguments are reviewed in this article and include: (1) an increased prevalence of endometr…

Future research in endometriosis must focus on pathogenesis studies in the baboon model, the early interactions between endometrial and peritoneal cells in the pelvic cavity at the time of menstruation, and potential differences between eut…

BACKGROUND: Endometrium can adhere to autologous peritoneum. This study was undertaken to determine the effect of the menstrual cycle phase and the presence and stage of endometriosis on in-vitro adhesion of endometrium onto autologous peri…

ObjectiveOur purpose was to test the hypothesis that menstruation and intrapelvic injection of endometrium for the induction of endometriosis affect inflammatory parameters in peritoneal fluid from baboons.Study designIn the first part of t…

The role of psycho-neuro-endocrine immunology in reproduction cytokines and testicular function cytokines and ovarian function cytokines in the cervical vaginal environment cytokine and growth factor networks in human endometrium from menst…

ObjectiveTo test the hypothesis that diagnostic laparoscopy can cause pelviperitoneal inflammation.DesignRetrospective analysis of data collected during a prospective controlled study in baboons.SettingAn academic research environment.Anima…

PurposeRisk factors for endometriosis were identified through data obtained from a case-control study at Brigham and Women's Hospital in Boston, Massachusetts.MethodsCases were 50 women with infertility-associated endometriosis. The primary…

Endometriosis is a complex and intriguing disease. If retrograde menstruation normally occurs, then why do all women not develop endometriosis? The exact prevalence of endometriosis is unknown; however, a 20% to 90% prevalency rate has been…

In women with endometriosis, changes in peripheral blood and peritoneal fluid white blood cell (WBC) populations have been reported, but it is known whether these alterations are casually related to or a consequence of endometriosis. The pu…

ObjectiveTo assess the degree of intraobserver and interobserver variability in endometriosis staging using the revised American Fertility Society (AFS) classification of endometriosis.DesignVideotapes of laparoscopies of 20 patients with e…

Prostaglandin H synthase, also known as cyclooxygenase, is an essential enzyme in prostaglandin synthesis. Using a monoclonal antibody and immunohistochemical techniques, we studied the localization of this enzyme in the female reproductive…