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INTRODUCTION: Each month, the endometrium is shed, regenerated, and transformed in response to changing hormone levels. These processes occur in a tightly regulated manner, and irregularities are linked with reproductive health conditions s…
BACKGROUND: Ovarian endometriosis (OE) is a leading cause of female infertility. Our previous work identified iron overload-driven oxidative stress and mitochondrial dysfunction in granulosa cells as key pathogenic features, yet the mechani…
We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis across 14 biobanks worldwide, including 32% non-European patient participants, as part of the Global Biobank Meta-Analysis Initiative (GBMI). Ou…
Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates t…
Endometriosis, a prevalent gynecological disorder marked by ectopic growth of endometrial-like tissue, demonstrates malignant tumor-like properties including aggressive adhesion and invasiveness. Emerging evidence implicates roundabout guid…
We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis consisting of a large portion (31%) of non-European samples across 14 biobanks worldwide as part of the Global Biobank Meta-Analysis Initiative …
Additional file 2. Data 1. Inhibition rate of natural compounds on ovarian cancer cells.
Additional file 3. Data 2. Primer sequence.
Endometriosis is a common gynecological disease, characterized by the presence of endometrial-like lesions outside the uterus. This debilitating disease causes chronic pelvic pain and infertility with limited therapeutics. Chemerin is a sec…
BACKGROUND: Yuzhi Zhixue Granule (YZG) is a traditional Chinese patent medicine for treating excessive menstrual flow caused by ovulatory dysfunctional uterine bleeding (ODUB) accompanied by heat syndrome. However, the underlying molecular …
Abstract Background: Yuzhi Zhixue Granule (YZG)is a traditional Chinese patent medicine for treating excessive menstrual flow caused by ovulatory dysfunctional uterine bleeding (ODUB) accompanied by heat syndrome. However, the underlying mo…
Endometriosis is one of the main causes for female infertility. Previous studies suggested that perfluoroalkyl substances (PFASs), a group of ubiquitous environmental chemicals with properties of endocrine disruption and reproductive toxici…
The invention discloses a Chinese medicinal compound effective component for treating gynecological diseases and a preparation method and application thereof. The effective component is prepared by obtaining water or ethanol extract of a Ch…
The invention discloses a Chinese medicinal compound effective component for treating gynecological diseases and a preparation method and application thereof. The effective component is prepared by obtaining water or ethanol extract of a Ch…
The invention discloses a Chinese medicinal compound effective component for treating gynecological diseases and a preparation method and application thereof. The effective component is prepared by obtaining water or ethanol extract of a Ch…
The invention discloses a Chinese medicinal compound effective component for treating gynecological diseases and a preparation method and application thereof. The effective component is prepared by obtaining water or ethanol extract of a Ch…