Liu Y

ObjectiveThe aim of this study was to compare the therapeutic efficacy of integrating virtual reality technology with conventional pelvic floor rehabilitation therapy versus conventional therapy alone in postpartum women with myofascial pel…

ObjectiveThis retrospective cohort study aimed to evaluate whether a goal-directed weight loss intervention prior to assisted reproductive technology (ART) improves live birth rates compared with immediate in vitro fertilization (IVF) witho…

ObjectiveTo investigate whether prolonged embryo culture increases the risk of gestational diabetes mellitus (GDM) in pregnancies conceived via frozen embryo transfer (FET).Research design and methodsIn this retrospective cohort study, 26 1…

BackgroundNon-neoplastic gynecological diseases substantially impact women of childbearing age (WCBA), contributing to global burden. Despite growing awareness, disparities in healthcare access remain widespread across regions and socioecon…

Premature ovarian insufficiency (POI) is a significant clinical challenge leading to amenorrhea and infertility in young women. While its etiology is complex, recent research has highlighted aberrant protein glycosylation as a novel and cru…

Endometriosis (EMs) is a prevalent, estrogen-dependent gynecological disorder characterized by the ectopic implantation and proliferation of endometrial-like tissue outside the uterine cavity, affecting approximately 10% of reproductive-age…

Abstract Hypoxia, a state of reduced oxygen availability, drives endometrial disease progression by inducing cellular reprogramming that promotes inflammation, angiogenesis, and aberrant cell survival in endometriosis and endometrial cance…

BackgroundAmong patients undergoing hysterectomy for benign indications, Black patients experience higher rates of perioperative complications across both abdominal and minimally invasive surgical routes. This disparity persists after adjus…

ObjectiveTo evaluate the impact of adjunctive levonorgestrel-releasing intrauterine device (LNG-IUD) placement on amenorrhea rates and hysterectomy risk following endometrial resection or ablation in women with abnormal uterine bleeding (AU…

Gynecological diseases represent a persistent global health burden. According to a WHO report, the global incidence of gynecological diseases exceeds 65%. Furthermore, over 90% of women suffer from gynecological issues to varying degrees. T…

The paradigm shift of lactate from a mere metabolic byproduct to a pleiotropic signaling molecule, coupled with the discovery of lactylation, provides a crucial framework for understanding how metabolic reprogramming drives systemic patholo…

Endometriosis (EMS) is a common gynecological disease that seriously affects women's health and quality of life. However, the detailed dynamic cellular and molecular mechanisms underlying EMS pathogenesis remain largely unknown. This study …

BACKGROUND: Predicting in vitro fertilization (IVF) pregnancy outcomes is crucial for individualized decision-making. However, due to complex interactions among multiple factors, accurate manual integration and assessment are challenging. T…

Acute severe joint pain is a major symptom in gouty arthritis (GA), and its adequate treatment represents an unmet medical need. Mrgprb2, a specific mast cell receptor, has been implicated in the generation of chronic pain by mobilizing mas…

Ovarian senescence is accompanied by inflammatory responses, yet the underlying mechanism remains incompletely elucidated. In this study, transcriptome sequencing was performed on ovarian granulosa cells from advanced-age patients and norma…

Yike Liu The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, People’s Republic of ChinaCorrespondence: Yike Liu, Email [email protected]

OBJECTIVE: To investigate the relationship between third-trimester antenatal depression (AND) and the number of pregnancies, considering the possible moderating role of dysmenorrhea. METHODS: A total of 1,178 pregnant women in their third t…

BackgroundHydrosalpinx affects 10-30% of infertile women, creating a hostile tubal microenvironment that impairs embryonic development. Although fluid embryotoxicity is recognised, specific toxic metabolites and their molecular mechanisms r…

Gallbladder carcinoma, among the most prevalent malignancies of the biliary system, often presents with insidious early symptoms. Delayed diagnosis of incidental gallbladder carcinoma frequently leads to therapeutic delays, significantly co…

Endometriosis is a benign yet aggressive disease characterized by enhanced proliferation and invasion of ectopic endometrial tissue. Identifying upstream regulators that co-regulate these processes will provide novel insights into endometri…

Epidemiological inconsistencies currently obscure the causal link between polychlorinated biphenyls (PCBs) and breast cancer. This review synthesizes multi-disciplinary evidence to characterize PCBs not as passive exposure correlates but as…

Endometriosis-associated ovarian cancer (EAOC) is a rare subtype of ovarian cancer arising from the malignant transformation of endometriosis (EMS). Despite growing clinical awareness, its underlying pathogenic mechanisms are not fully unde…