Andreas N Schüring

Adenomyosis, a prevalent gynecologic condition involving invasion of endometrial tissue into the myometrium, remains poorly understood in terms of its molecular pathogenesis. Numb, an important regulator of cellular destiny and stem cell ma…

Introduction: Adenomyosis, a prevalent gynecologic condition involving invasion of endometrial tissue into the myometrium, remains poorly understood in terms of its molecular pathogenesis. Numb, an important regulator of cellular destiny an…

Adenomyosis (AM) is a gynecological disease characterized by the invasion of endometrial glands and stroma within the myometrium. The etiology and pathogenesis of AM remain inadequately understood. Pale cells were identified as a novel cell…

INTRODUCTION: Adenomyosis is a special subtype of endometriosis, affecting the myometrium, affecting about 20% of women in the reproductive age period. Clinical symptoms and intensity are diverse and can vary from heavy menstrual bleeding a…

Abstract Aims The aim of this official guideline published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG) in cooperation with the Austrian Society for Gynaecology and Obstetrics (OEGGG) and the Swiss Society for …

PurposeSuperficial peritoneal endometriotic (pEM) lesions are composed of endometrial glands and stroma, in addition to a third component-myofibroblasts and smooth muscles (SM)-like cells. The latter develops secondary to a metaplasia. In t…

PurposeTo study if short-term exposure (2 h and 6 h) of endometrial/endometriotic tissues and cells to 10% seminal plasma (SP) can induce EMT/metaplasia.MethodsBasic research experimental study was carried out in a University hospital-based…

Previous studies reported increased expression of the notch pathway-associated protein Musashi-1 in endometriosis. This case–control study investigates an association of the endometrial stem cell markers notch-1 and numb with endometriosis.…

Previous studies reported increased expression of the notch pathway-associated protein Musashi-1 in endometriosis. This case-control study investigates an association of the endometrial stem cell markers notch-1 and numb with endometriosis.…

Endometriosis is characterized by growth of endometrial tissue at ectopic locations. Down-regulation of microRNA miR-200b is observed in endometriosis and malignant disease, driving tumour cells towards an invasive state by enhancing epithe…

ObjectiveTo study the expression and function of syndecan-4 in endometriosis.DesignHistopathological investigation of eutopic endometrium and experimental laboratory study on a cell line derived from epithelial endometriotic cells (12Z).Set…

Der Begriff Endometriose ist definiert als das Vorkommen von Endometrium oder Endometrium ähnlichem Gewebe außerhalb des Cavum uteri. (Giudice 2010) Die Syndecane sind transmembranöse Rezeptoren auf der Zelloberfläche, die für die Zelladhäs…

PURPOSE: To evaluate the presence of a lesion indicative of endometriosis with transvaginal elastography. MATERIALS AND METHODS: Transvaginal ultrasound and clinical examination were carried out in 48 women with clinical symptoms indicative…

Purpose: To evaluate the presence of an endometriotic lesion indicative of endometriosis with transvaginal elastography.

microRNAs (miRNAs) are small, non-coding RNAs which regulate gene expression at the posttranscriptional and translational level. Due to their high regulatory capacity, they are capable of modulating a variety of physiological and pathophysi…

OBJECTIVE: To study the function of miR-145, known to be dysregulated in endometriosis, and to identify its target genes in an in vitro endometriosis model. DESIGN: Experimental laboratory study. SETTING: University medical centers. PATI…

microRNAs are small non-coding RNAs which regulate gene expression at the posttranscriptional and translational level. microRNAs have previously been demonstrated to be dysregulated in endometriosis, a hormone-dependent disease associated w…

ObjectiveTo study the function of syndecan-1 (SDC1) and its potential regulator miR-10b in endometriosis.DesignExperimental laboratory study.SettingUniversity medical center.Patient(s)Not applicable.Intervention(s)The human endometriotic ce…

Expression of the pluripotency factors SOX-2, OCT-4, KLF-4, and NANOG was analyzed by quantitative real-time polymerase chain reaction, immunohistochemistry, and immunofluorescence microscopy in the endometrium, myometrium, and endometrioti…

Background. Proliferation and differentiation of the endometrium are regulated by estrogen and progesterone. The enormous regenerative capacity of the endometrium is thought to be based on the activity of adult stem cells. However, informat…

Endometrial cell clones derived from in vitro cultured purified stromal cells obtained by endometrial biopsy display characteristic stem cell features, including clonality; long-term culturing properties; multilineage differentiation potent…

Adult stem cells are thought to be responsible for the high regenerative capacity of the human endometrium, and have been implicated in the pathology of endometriosis and endometrial carcinoma. The RNA-binding protein Musashi-1 is associate…