Edgardo Somigliana

INTRODUCTION: All medical treatments for endometriosis are equally effective in relieving pain. However, all of them alleviate pain symptoms for as long as they are used, but pain always relapses when medication is discontinued. Therefore, …

PurposeThe present study aimed to gather information on the impact of Alpha/European Society of Human Reproduction and Embryology (ESHRE) consensus regarding oocytes with aggregates of smooth endoplasmic reticulum (SERa) on in vitro fertili…

BACKGROUND: Vascular endothelial growth factor (VEGF) is a potent stimulus of angiogenesis potentially contri-buting to the pathogenesis of endometriosis. The aim of this study was to investigate the potential association between the single…

Deep endometriosis is a demanding condition that is associated with infertility. However, evidence supporting a direct link between deep endometriosis and infertility is weak. In fact, infertility in affected patients is more likely to be e…

Vitamin D is a fat-soluble pro-hormone that plays an important role in bone homeostasis; beside this principal function, vitamin D promotes modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. In addi…

BACKGROUND: Patients, now generally well informed through dedicated websites and support organizations, are beginning to look askance at clinical experimentation. We conducted a survey investigation to verify whether women with endometriosi…

The relationship between rectovaginal-bowel endometriosis and fertility is unclear. Nevertheless, extirpative surgery, including colorectal resection, is being fostered as a fertility-enhancing procedure. Adenomyosis and deep endometriosis …

The laparoscopic excision of ovarian endometriomas appears to increase the chances of spontaneous conception, but the value of this treatment in women selected for IVF–ICSI cycles is debated. Studies recruiting women with unilat-eral diseas…

Research on the effect of adenomyosis on the rate of success of IVF is controversial. Differences in study design, study power, criteria and instrument used to diagnose adenomyosis and choice of controls may explain these discrepancies. To …

STUDY QUESTION: Is the prevalence of blue eye colour higher in women with deep endometriosis? SUMMARY ANSWER: Blue eye colour is more common in women with deep endometriosis when compared with both women with ovarian endometriomas and wome…

ObjectiveTo evaluate whether accidental contamination of follicular fluid with endometrioma content during oocytes retrieval affects IVF outcome.Study designWe set up a retrospective review of women undergoing IVF in our infertility unit du…

ObjectiveTo evaluate whether the presence of endometriomas affects ovarian function.DesignProspective cohort study.SettingInfertility unit of an academic setting.Patient(s)Twenty-nine women undergoing an IVF cycle.Intervention(s)Prospective…

ObjectiveThere is consistent evidence demonstrating that laparoscopic removal of benign ovarian cysts significantly damages the ovarian reserve. In contrast, the pre-operative impact of these cysts on the ovarian reserve is yet controversia…

BACKGROUND: Clinical data suggest that the presence of an ovarian endometrioma may cause per se damage to the surrounding otherwise healthy ovarian tissue. However, the basic research has so far done a limited job in trying to understand th…

Ovarian endometriomas are found in a consistent proportion of patients with endometriosis and are associated with a more severe form of the disease. The endometriotic tissue lining the inside of the endometrioma has been extensively studied…

Several studies aimed to disentangle whether pregnancy influences the growth of uterine fibroids but results were inconsistent. In this study, we speculated that fibroid enlargement during pregnancy may not be linear and we hypothesized tha…

PurposeTo compare two embryo grouping strategies.MethodsRetrospective time-course analysis in two different centres. Two culture protocols were used at the zygote stage: "Random Group" in which zygotes were randomly grouped and "Definite Gr…

STUDY QUESTION: Is adenomyosis associated with IVF/ICSI outcome in terms of clinical pregnancy rate? SUMMARY ANSWER: In a meta-analysis of published data, women with adenomyosis had a 28% reduction in the likelihood of clinical pregnancy at…

Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the human reproductive system in both genders, but no comprehensive analysis of the potential relationship between vitamin D status…

SEVERAL MILLION WOMEN from different ethnic and social groups suffer from pelvic endometriosis, which is a complex disorder characterized by the presence of endometrial tissue in ectopic sites outside the uterus. Endometriosis is a chronic …

Endometriosis is defined as the presence of endometrial-type mucosa outside the uterine cavity. Of the proposed pathogenic theories (retrograde menstruation, coelomic metaplasia and Müllerian remnants), none explain all the different types …

OBJECTIVE: To evaluate IVF outcome in women with unoperated bilateral endometriomas. DESIGN: Multicenter retrospective cohort study. SETTINGS: Two infertility units. PATIENT(S): Thirty-nine women with bilateral endometriomas matched with…

The presence of a primary endometrioma and its surgical excision may be detrimental for future fertility. After removal of the primary tumor, recurrence is common: 30% to 50% after 2 to 5 years of follow-up. The likelihood of conception aft…

The high rate of disease recurrence after surgery is critical and frustrating for women with endometriosis. Adjuvant treatments using a 3- to 6-months course of hormone therapy after surgery have been extensively investigated during the las…