Sharpe-Timms KL

No ORCID on file · 38 papers in corpus · active 1994-2025

Study types

  • article 18
  • other 9
  • review 8
  • dissertation 1
  • letter 1

Condition tags

  • endometriosis 37
  • infertility 5
  • endometrioma 1
review 2001
Endometrial Anomalies in Women with Endometriosis
Annals of the New York Academy of Sciences ·doi:10.1111/j.1749-6632.2001.tb03797.x

Endometriotic lesions are defined by extrauterine growth of endometrial glands and stroma. Retrograde menstruation with subsequent attachment, invasion, and neovascularization are believed to give rise to the endometriotic lesions. As most …

other 2001
Interleukin-6 differentially stimulates haptoglobin production by peritoneal and endometriotic cells in vitro: a model for endometrial-peritoneal interaction in endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.86.6.7613

Based on our previous observation that peritoneal endometriotic (PE) lesions synthesize in vivo substantially more haptoglobin (Hp) than related eutopic tissues, we hypothesized that this increase in Hp production was due to endometrial-per…

article 2000
Differential expression and localization of de-novo synthesized endometriotic haptoglobin in endometrium and endometriotic lesions
Human Reproduction ·doi:10.1093/humrep/15.10.2180

Endometriosis protein-I (ENDO-I) mRNA expression and protein localization were evaluated using in-situ hybridization and immunohistochemistry in endometriotic lesions and eutopic endometrium from women with endometriosis, and in eutopic end…

article 1999
Peritoneal endometriotic lesions differentially express a haptoglobin-like gene*
Molecular human reproduction ·doi:10.1093/molehr/5.1.71

A unique glycoprotein, called endometriosis protein-I (ENDO-I), has previously been shown to be synthesized and secreted by rat and human endometriotic explants. Furthermore, the N-terminal amino acid sequence analysis showed that ENDO-I sh…

other 1998
Endometriotic lesions synthesize and secrete a haptoglobin-like protein
Biology of reproduction ·doi:10.1095/biolreprod58.4.988

To explore the identity and possible function of endometriosis protein-I (ENDO-I), which is an acidic glycoprotein synthesized and secreted by endometriotic lesions, partial amino acid sequence and cDNA sequence were determined. Partially p…

article 1998
Gonadotropin-Releasing Hormone Agonist (GnRH-a) Therapy Alters Activity of Plasminogen Activators, Matrix Metalloproteinases, and Their Inhibitors in Rat Models for Adhesion Formation and Endometriosis: Potential GnRH-a–Regulated Mechanisms Reducing Adhesion Formation
Fertility and Sterility ·doi:10.1016/s0015-0282(98)00032-6

ObjectiveTo evaluate the effects of a gonadotropin-releasing hormone agonist (GnRH-a) on plasminogen activator (PA), matrix metalloproteinase (MMP), plasminogen activator inhibitor (PAI) and matrix metalloproteinase inhibitor (MMPI) activit…

article 1998
Tissue Inhibitor of Metalloproteinase-1 Concentrations are Attenuated in Peritoneal Fluid and Sera of Women with Endometriosis and Restored in Sera by Gonadotropin-Releasing Hormone Agonist Therapy
Fertility and Sterility ·doi:10.1016/s0015-0282(98)00075-2

ObjectiveTo establish tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in peritoneal fluid (PF) and sera of women with endometriosis and compare them to disease-free controls.DesignProspective randomized study.SettingAcademic…

review 1997
BASIC RESEARCH IN ENDOMETRIOSIS
Obstetrics and gynecology clinics of North America ·doi:10.1016/s0889-8545(05)70304-1

A more thorough understanding of the mechanisms associated with the cause and pathophysiology of endometriosis may help in the development of new diagnostic and therapeutic methods for the management of endometriosis. Research has begun to …

other 1996
Inability to establish ectopic endometrium in a natural killer cell-deficient murine model. Immunologic, histologic and histochemical assessment
The Journal of reproductive medicine

OBJECTIVE: To investigate what effect natural killer (NK) cells have on the implantation of heterologous endometrial scrapings. STUDY DESIGN: Anti-asialo GM1 (AA-GM1) anti-sera have been shown to eliminate NK cell activity in various strai…

review 1996
Steroid and growth factor regulation of matrix metalloproteinase expression and endometriosis
Seminars in reproductive endocrinology ·doi:10.1055/s-2007-1016334
other 1995
Gonadotropin-releasing hormone agonist therapy reduces postoperative adhesion formation and reformation after adhesiolysis in rat models for adhesion formation and endometriosis
Fertility and Sterility ·doi:10.1016/s0015-0282(16)57554-2

OBJECTIVES: To evaluate the effectiveness of GnRH agonist (GnRH-a) therapy on adhesion formation and reformation in established rat models for surgically induced adhesion formation and endometriosis. DESIGN: Before surgery, female Sprague-…

article 1995
Partial purification and amino acid sequence analysis of endometriosis protein-II (ENDO-II) reveals homology with tissue inhibitor of metalloproteinases-1 (TIMP-1).
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.80.12.8530636

De novo synthesized endometriosis protein-II (ENDO-II; M(r) 28,000 to 32,000; pI 7.0 to 9.0) was partially purified from rat endometriotic tissue culture media using affinity chromatography and two-dimensional SDS-PAGE. The protein was elec…

article 1994
Immunohistochemical localization of granulocyte-macrophage colony-stimulating factor in matched endometriosis and endometrial tissues
American Journal of Obstetrics and Gynecology ·doi:10.1016/0002-9378(94)90091-4

ObjectiveMurine endometrial granulocyte-macrophage colony-stimulating factor has been related to macrophage recruitment and activation and postulated to mediate reproductive events. This study was designed to determine whether granulocyte-m…