Julie A. Birt

ORCID: 0000-0003-2105-2056 · 5 papers in corpus
article 2013
Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first-generation and second-generation embryos
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.07.007

ObjectiveTo characterize multigenerational gene expression anomalies in eight-cell stage embryos associated with developmental exposure to endometriosis.DesignUsing an endometriosis model in rats (F0 founder generation) to evaluate gene exp…

article 2013
Elevated Peritoneal Fluid TNF-α Incites Ovarian Early Growth Response Factor 1 Expression and Downstream Protease Mediators: A Correlation With Ovulatory Dysfunction in Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719113477479

Endometriosis-associated infertility manifests itself via multiple, poorly understood mechanisms. Our goal was to characterize signaling pathways, between peritoneal endometriotic lesions and the ovary, leading to failed ovulation. Genome-w…

review 2012
Cellular and molecular basis for endometriosis-associated infertility
Cell and tissue research ·doi:10.1007/s00441-011-1309-0

Endometriosis is a gynecological disease characterized by the presence of endometrial glandular epithelial and stromal cells growing in the extra-uterine environment. The disease afflicts 10%-15% of menstruating women causing debilitating p…

dissertation 2010
Heritable, differential gene expression in pre-implantation embryos from rats with endometriosis and their daughters
·doi:10.32469/10355/10650

The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.

other 2010
Neutralizing TIMP1 restores fecundity in a rat model of endometriosis and treating control rats with TIMP1 causes anomalies in ovarian function and embryo development
Biology of reproduction ·doi:10.1095/biolreprod.109.083287

Human and rat endometriotic lesions synthesize and secrete tissue inhibitor of metalloproteinase 1 (TIMP1). More TIMP1 localizes in the ovarian theca in an established rat model for endometriosis (Endo) when compared to surgical controls (S…