Amanda Graham

No ORCID on file · 17 papers in corpus · active 2011-2025

Study types

  • article 16
  • other 1

Condition tags

  • endometriosis 11
  • mesh:D004715 8
  • infertility 3
  • adenomyosis 3
article 2025
A MOUSE MODEL OF UTERINE TRAUMA ALTERS EXPRESSION OF A REST-MMP PATHWAY AND IS ASSOCIATED WITH DEVELOPMENT OF ADENOMYOSIS
·doi:10.1016/j.fertnstert.2025.07.587
article 2024
Prefoldin-5 Expression Is Elevated in Eutopic and Ectopic Endometriotic Epithelium and Modulates Endometriotic Epithelial Cell Proliferation and Migration In Vitro
International journal of molecular sciences ·doi:10.3390/ijms25042390

Endometriosis is a common disease among women of reproductive age in which endometrial tissue grows in ectopic localizations, primarily within the pelvic cavity. These ectopic "lesions" grow as well as migrate and invade underlying tissues.…

article 2023
EUTOPIC ENDOMETRIAL RE-1 SILENCING TRANSCRIPTION FACTOR IS REDUCED IN PATIENTS WITH ENDOMETRIOSIS AND IS ASSOCIATED WITH CHANGES IN NEURONAL MARKERS AND PAIN-LIKE BEHAVIOR IN A KNOCKOUT MOUSE MODEL
·doi:10.1016/j.fertnstert.2023.08.605
article 2023
EVALUATING THE MECHANISTIC INVOLVEMENT OF A RE-1 SILENCING TRANSCRIPTION FACTOR AND MATRIX METALLOPROTEINASE IN ADENOMYOSIS PATHOPHYSIOLOGY
·doi:10.1016/j.fertnstert.2023.08.825
article 2023
RPLP1 Is Up-Regulated in Human Adenomyosis and Endometrial Adenocarcinoma Epithelial Cells and Is Essential for Cell Survival and Migration In Vitro
International journal of molecular sciences ·doi:10.3390/ijms24032690

Adenomyosis is defined as the development of endometrial epithelial glands and stroma within the myometrial layer of the uterus. These "ectopic" lesions share many cellular characteristics with endometriotic epithelial cells as well as endo…

article 2023
Targeting c-MYC: a potential non-hormonal therapeutic approach for endometriosis treatment
Frontiers in cell and developmental biology ·doi:10.3389/fcell.2023.1225055

Endometriosis is a benign gynecological disease in which eutopic endometrial tissue composed of glands and stroma grow within the pelvic cavity. The disease affects females of reproductive age and is characterized by pelvic pain, infertilit…

article 2022
Dissecting the miR-451a-Mif Pathway in Endometriosis Pathophysiology Using a Syngeneic Mouse Model: Temporal Expression of Lesion Mif Receptors, Cd74 and Cxcr4
Biomedicines ·doi:10.3390/biomedicines10071699

Endometriosis is an enigmatic disease characterized by pain and infertility in which endometrial tissue grows in ectopic locations, predominantly the pelvic cavity. The pathogenesis and pathophysiology of endometriosis is complex and postul…

article 2022
The Relationship and Expression of miR-451a, miR-25-3p and PTEN in Early Peritoneal Endometriotic Lesions and Their Modulation In Vitro
International journal of molecular sciences ·doi:10.3390/ijms23115862

Background: miR-451a can function as a tumor suppresser and has been shown to be elevated in both endometriotic lesion tissue and serum from women with endometriosis. To further explore the role of miR-451a in the pathophysiology of endomet…

article 2022
The uterine natural killer cell, cytotoxic T lymphocyte, and granulysin levels are elevated in the endometrium of women with nonstructural abnormal uterine bleeding
·doi:10.1016/j.xfss.2022.04.003

OBJECTIVE: To examine the expression of uterine natural killer (uNK) cells and cytotoxic T lymphocytes (CTLs) in endometrial biopsies from reproductive-age women with and without nonstructural abnormal uterine bleeding (AUB) and evaluate th…

article 2019
60S acidic ribosomal protein P1 (RPLP1) is elevated in human endometriotic tissue and in a murine model of endometriosis and is essential for endometriotic epithelial cell survival in vitro
Molecular human reproduction ·doi:10.1093/molehr/gaz065

Endometriosis is a female disease which is defined as the presence of ectopic endometrial tissue and is dependent on estrogen for its survival in these ectopic locations. Expression of the ribosomal protein large P1 (RPLP1) is associated wi…

article 2019
Human endometriotic lesion expression of the miR-144-3p/miR-451a cluster, its correlation with markers of cell survival and origin of lesion content
Scientific reports ·doi:10.1038/s41598-019-45243-7

Endometriosis is an inflammatory condition in which endometrial tissue grows in ectopic locations. Survival and growth of these ectopic lesions is associated with pain and infertility. MicroRNAs (miRNAs) have been postulated to play a role …

article 2018
Macrophage Migration Inhibitory Factor Receptor, CD74, is Overexpressed in Human and Baboon (Papio Anubis) Endometriotic Lesions and Modulates Endometriotic Epithelial Cell Survival and Interleukin 8 Expression
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719118766262
article 2018
MIR-144/MIR-451 cluster expression, regulation and functional significance in endometriosis
·doi:10.1016/j.fertnstert.2018.07.1082
article 2016
Serum miR-451a Levels Are Significantly Elevated in Women With Endometriosis and Recapitulated in Baboons (Papio anubis) With Experimentally-Induced Disease
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719116681519
article 2015
The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival
Human Reproduction ·doi:10.1093/humrep/dev005

study question: What is the role of microRNA-451 (miR-451) in human endometriotic tissue? summary answer: miR451 expression was elevated in endometriotic lesion tissue. MiR451 modulated the expression of macrophage migration inhibitory fact…

other 2014
miR-451 deficiency is associated with altered endometrial fibrinogen alpha chain expression and reduced endometriotic implant establishment in an experimental mouse model
PloS one ·doi:10.1371/journal.pone.0100336

Endometriosis is defined as the growth of endometrial glandular and stromal components in ectopic locations and affects as many as 10% of all women of reproductive age. Despite its high prevalence, the pathogenesis of endometriosis remains …

article 2011
POSTER VIEWING SESSION - ENDOMETRIOSIS, ENDOMETRIUM, IMPLANTATION AND FALLOPIAN TUBE
·doi:10.1093/humrep/26.s1.80