Mamiko Okamoto

No ORCID on file · 17 papers in corpus · active 2013-2025

Study types

  • article 13
  • review 3
  • book-chapter 1

Condition tags

  • endometriosis 14
  • mesh:D004715 9
  • adenomyosis 1
article 2025
Overexpression of hsa-miR-132-5p in ovarian endometriotic stromal cells promoted acquisition of endometriotic phenotype
·doi:10.1177/22840265251340361

Objective: The microRNA hsa-miR-132-5p is upregulated in endometriotic cyst stromal cells (ECSCs). We investigate how hsa-miR-132-5p affects the progression of endometriosis. Methods: Normal endometrial stromal cells (NESCs) that have been …

article 2022
Life-threatening anemia due to uterine fibroids: A case series
Experimental and therapeutic medicine ·doi:10.3892/etm.2022.11605

Uterine fibroids are associated with heavy menstrual bleeding, abdominal discomfort, subfertility and a reduced quality of life. The present study reported a case series of life-threatening anemia with hemoglobin levels <2.0 g/dl caused by …

review 2021
Promising therapeutic targets of endometriosis obtained from microRNA studies
Medical molecular morphology ·doi:10.1007/s00795-021-00308-3
review 2021
Role of repressed microRNAs in endometriosis
Medical molecular morphology ·doi:10.1007/s00795-021-00303-8
article 2020
hsa-miR-100-5p, an overexpressed miRNA in human ovarian endometriotic stromal cells, promotes invasion through attenuation of SMARCD1 expression
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-020-00590-3

BACKGROUND: A number of microRNAs are aberrantly expressed in endometriosis and are involved in its pathogenesis. Our previous study demonstrated that has-miR-100-5p expression is enhanced in human endometriotic cyst stromal cells (ECSCs). …

article 2016
Decidualization Differentially Regulates microRNA Expression in Eutopic and Ectopic Endometrial Stromal Cells
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719116657894
article 2016
miR-503, a microRNA epigenetically repressed in endometriosis, induces apoptosis and cell-cycle arrest and inhibits cell proliferation, angiogenesis, and contractility of human ovarian endometriotic stromal cells
Human Reproduction ·doi:10.1093/humrep/dew217

STUDY QUESTION: Is the micro-RNA (miRNA) miR-503, downregulated in endometriotic cyst stromal cells (ECSCs) and does this affect the cell cycle, cell proliferation, angiogenesis and contractility of these cells? SUMMARY ANSWER: miR-503 expr…

article 2015
ISP-9-1 MicroRNA-210-mediated pathway to progestin-induced decidualization in endometriosis(Group 9 Reproduction 1,IS Poster,International Session)
article 2015
The effects of STAT3 inhibitors on endometriotic cyst stromal cells
·doi:10.1016/j.jri.2015.09.054
review 2014
Aberrant histone modification in endometriosis
Frontiers in bioscience (Landmark edition) ·doi:10.2741/4276

Accumulating evidence suggests that epigenetic aberrations play definite roles in the pathogenesis of endometriosis. These include aberrations in genomic DNA methylation, microRNA expression, and histone modification. The aberrant histone m…

article 2014
DR6 is epigenetically involved in the pathogenesis of endometriosis by creating the proliferative and anti-apoptotic characteristics
·doi:10.1016/j.jri.2014.09.026
article 2014
Endometrioid Adenocarcinoma Arising from Intestinal Endometriosis
·doi:10.5301/je.5000186

Purpose Gastrointestinal involvement of endometriosis may exist in up to 37% of women suffering from endometriosis, but malignant transformation of intestinal endometriosis is extremely rare. In this case report, we present a case of endome…

article 2014
Enhanced miR-210 expression promotes the pathogenesis of endometriosis through activation of signal transducer and activator of transcription 3
Human Reproduction ·doi:10.1093/humrep/deu332

STUDY QUESTION: What are the roles of the microRNA miR-210-an miRNA that is up-regulated in endometriotic cyst stromal cells (ECSCs)-in the pathogenesis of endometriosis? SUMMARY ANSWER: Up-regulated miR-210 expression in ECSCs is involved …

article 2014
ISP-18-1 Death receptor 6 is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis(Group 18 Reproduction 1,IS Poster,International Session) :
book-chapter 2014
Potential New Drugs for Endometriosis: Experimental Evidence
·doi:10.1007/978-4-431-54421-0_16
article 2013
Endometriosis of the perineum
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.12003

Endometriosis of the perineum and vulva is extremely rare, with the most common site being episiotomy scars. We report here a case of spontaneously developing perineal endometriosis successfully treated with local excision. A 39-year-old wo…

article 2013
Death Receptor 6 is Epigenetically Silenced by Histone Deacetylation in Endometriosis and Promotes the Pathogenesis of Endometriosis
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12155

PROBLEM: The purpose of this study is to evaluate the involvement of death receptor (DR) 6 in the pathogenesis of endometriosis. METHODS OF STUDY: Endometriotic cyst stromal cells (ECSCs) and normal endometrial stromal cells (NESCs) were is…