Takaoka O

No ORCID on file · 12 papers in corpus · active 2015-2026

Study types

  • article 8
  • other 1
  • preprint 1
  • review 1

Condition tags

  • endometriosis 10
  • endometrioma 4
  • die_deep_infiltrating 1
preprint 2026
A multicenter randomized placebo-controlled trial evaluating daidzein-rich isoflavone aglycones in endometriosis-associated dysmenorrhea
·doi:10.21203/rs.3.rs-9799296/v1

Abstract Background Endometriosis-associated dysmenorrhea is commonly managed with hormonal therapies that suppress ovulation, limiting their use in women desiring fertility. Daidzein-rich isoflavone aglycones (DRIAs), a food-derived comp…

other 2025
Daidzein-rich isoflavone aglycones inhibit 17β-hydroxysteroid dehydrogenase 1 and increase estrogen sulfotransferase in endometriosis
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology ·doi:10.1080/09513590.2025.2516202

OBJECTIVE: Endometriosis is an estrogen-dependent disease wherein isoflavones interact with estrogen receptors. Daidzein-rich isoflavone aglycones (DRIAs) have been shown to inhibit cell proliferation and aromatase activity in vitro and in …

article 2023
Hepcidin as a key regulator of iron homeostasis triggers inflammatory features in the normal endometrium
Free radical biology & medicine ·doi:10.1016/j.freeradbiomed.2023.10.402

Menstrual blood, containing high iron levels, can undergo retrograde transport into the abdominal cavity. Excess iron causes oxidative stress and inflammation. Iron metabolism is regulated by hepcidin, and serum hepcidin levels are increase…

article 2022
Low-Nutrient Environment-Induced Changes in Inflammation, Cell Proliferation, and PGC-1α Expression in Stromal Cells with Ovarian Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-022-01089-5

Although nutrient status plays an important role in cell metabolism, its significance in endometriosis is obscure. Herein, we investigated the effects of a low-nutrient microenvironment on endometriosis. Stromal cells (SCs) from ovarian end…

2022
Robot-assisted laparoscopic hysterectomy for early-stage endometrial cancer with massive uterine leiomyomas: A case report.
International journal of surgery case reports ·doi:10.1016/j.ijscr.2022.107473

Introduction and importanceCompared to conventional laparoscopic surgery, robot-assisted surgery enables precise operation, with the aid of high-resolution 3D images and articulated forceps, even in cases where the uterus is very large.Case…

review 2019
Local estrogen formation and its regulation in endometriosis
Reproductive medicine and biology ·doi:10.1002/rmb2.12285

BACKGROUND: It has been well established that endometriosis is an estrogen-dependent disease. Although the exact pathogenesis of the disease is still unclear, it is known to be characterized by estrogen-dependent growth and maintenance of t…

article 2018
Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2018.04.004

Endometriosis is an estrogen-dependent disease, and isoflavones interact with estrogen receptors. The purposes of this study are to investigate the in vitro and in vivo effects of daidzein-rich isoflavone aglycones (DRIAs), dietary suppleme…

article 2018
Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.13725

AIM: We aimed to evaluate whether hormonal therapy immediately after postsurgical recurrence of ovarian endometrioma controls disease progression and can be an alternative therapeutic option to avoid multiple repeat surgeries. METHODS: We e…

article 2017
Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2017-00052

Context: Endometriosis is a chronic inflammatory disease associated with altered immune response to endometrial cells facilitating the implantation and proliferation of ectopic endometrial tissues. Although regulatory T (Treg) cells play a …

article 2016
Enlarged uterine corpus volume in women with endometriosis: Assessment using three‐dimensional reconstruction of pelvic magnetic resonance images
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.13153

AIM: To assess and compare the uterine volume and endometrium length between women with and without endometriosis, using pelvic magnetic resonance imaging scans. METHODS: In this case-control study, a total of 75 nulligravid women (aged 20-…

article 2015
Dienogest reduces HSD17β1 expression and activity in endometriosis
The Journal of endocrinology ·doi:10.1530/joe-15-0052

Endometriosis is an estrogen-dependent disease. Abnormally biosynthesized estrogens in endometriotic tissues induce the growth of the lesion and worsen endometriosis-associated pelvic pain. Dienogest (DNG), a selective progesterone receptor…

article 2015
G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.01.026

ObjectiveTo demonstrate the effects of the selective G protein-coupled estrogen receptor 1 (GPER) agonist G-1 in human ovarian endometriotic stromal cells (ESCs).DesignExperimental in vitro study.SettingUniversity hospital.Patient(s)A total…