Rothman KJ

Study questionTo what extent is male physical activity (PA) associated with fecundability (per-cycle probability of conception)?Summary answerPreconception levels of vigorous, moderate, or total PA were not consistently associated with fecu…

Study questionTo what extent are self-reported diagnoses of food allergies associated with fecundability, the per-cycle probability of conception?Summary answerFecundability was not appreciably associated with self-reported food allergy dia…

Study questionTo what extent do self-reported sleep duration and non-daytime work schedules in either partner affect the rate of spontaneous abortion (SAB)?Summary answerIncidence of SAB had little association with female sleep duration and…

BackgroundThe use of fertility indicators to predict ovulation has largely been studied for contraceptive purposes, while less so as fertility-promoting tools.ObjectiveTo investigate the association between fertility indicators and fecundab…

Study questionTo what extent is preconception maternal or paternal coronavirus disease 2019 (COVID-19) vaccination associated with miscarriage incidence?Summary answerCOVID-19 vaccination in either partner at any time before conception is n…

ObjectiveTo assess the effect of randomization to FertilityFriend.com, a mobile computing fertility-tracking app, on fecundability.DesignParallel non-blinded randomized controlled trial nested within the Pregnancy Study Online (PRESTO), a N…

ObjectivesTo evaluate the association between preconception contraceptive use and miscarriage.DesignProspective cohort study.SettingResidents of the United States of America or Canada, recruited from 2013 until the end of 2022.Participants1…

Few studies have evaluated the association between periodontitis and spontaneous abortion (SAB), and all had limitations. We used data from the Pregnancy Study Online (PRESTO), a prospective preconception cohort study of 3,444 pregnancy pla…

ObjectiveTo evaluate the association between seasonal influenza vaccination and miscarriage using data from an ongoing, prospective cohort study.MethodsWe analyzed 2013-2022 data from PRESTO (Pregnancy Study Online), a prospective prepregna…

PurposeTo evaluate the relationships among history of asthma, asthma severity, and spontaneous abortion (SAB).MethodsPregnancy Study Online is a preconception cohort study of North American couples. During the preconception period, female p…

ObjectiveTo explore to what extent intrauterine device (IUD) expulsion is associated with demographic and clinical risk factors.MethodsThe APEX-IUD (Association of Perforation and Expulsion of IntraUterine Devices) study was a U.S. cohort s…

BackgroundRefusal to participate in studies related to sexual health can compromise the internal and external validity of findings. Research examining non-response to sexual health studies has primarily focused on predictors such as specifi…

BackgroundMigraine is common among females of reproductive age (estimated prevalence:17-24%) and may be associated with reproductive health through underlying central nervous system excitability, autoimmune conditions, and autonomic dysfunc…

Study questionDo daughters of older mothers have lower fecundability?Summary answerIn this cohort study of North American pregnancy planners, there was virtually no association between maternal age ≥35 years and daughters' fecundability.Wha…

Study questionIs a history of periodontitis among women associated with reduced fecundability?Summary answerA history of periodontitis, as assessed by three different self-reported measures, may be associated with reduced fecundability.What…

PurposeAsthma has been positively associated with irregular menses and infertility in some studies, but data are limited on the relation between asthma medication use and fecundability (i.e., average per-cycle probability of conception amon…

ObjectiveTo evaluate the association between pregravid use of a variety of contraceptive methods and subsequent fecundability.DesignProspective cohort study.SettingDenmark and North America, 2007-19.Participants17 954 women who had tried to…

ObjectiveTo quantify the frequency of use of selected fertility awareness indicators and to assess their influence on fecundability.DesignWeb-based prospective cohort study.SettingNot applicable.Patient(s)Female pregnancy planners, aged 21-…

The association between dietary fat and fertility is not well studied. We evaluated intakes of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, trans fatty acids (TFA), ω-3 fatty acids, and ω-6 fat…

BackgroundThe synthetic solvent tetrachloroethylene (PCE), commonly used in dry cleaning operations, is a human neurotoxicant and carcinogen. However, its effect on reproduction is poorly understood, as prior studies have been limited to sm…

BackgroundAnimal studies have shown that a high intake of galactose, a breakdown product of lactose, increases ovarian toxicity. Few epidemiologic studies, to our knowledge, have examined the association between dairy intake and fertility, …

Study questionTo what extent is preconception use of pain-relieving medication associated with female fecundability?Summary answerWomen who used naproxen or opioids had slightly lower fecundability than women who did not use any pain-reliev…

PurposeThe aim of this study was to evaluate the association between menstrual cycle characteristics in early life and adulthood and fecundability.MethodsPregnancy Study Online (PRESTO) is an Internet-based preconception cohort study of pre…