Lauren A. Wise

Racialized economic segregation is a known determinant of health disparities that has been associated with adverse pregnancy outcomes. However, no study has investigated its association with fecundability, the per-cycle probability of conce…

Study questionTo what extent is male physical activity (PA) associated with fecundability (per-cycle probability of conception)?Summary answerPreconception levels of vigorous, moderate, or total PA were not consistently associated with fecu…

OBJECTIVE: To assess whether exposure to lower-chlorinated PCBs from building materials is associated with increased incidence of UL, endometriosis, and PCOS in female residents. METHODS: We studied 21,619 residents of two Danish partially…

Study questionTo what extent are there racial and ethnic disparities in fecundability in North America?Summary answerIn a North American preconception cohort study, we observed large differences in fecundability across racial and ethnic gro…

Study questionTo what extent are self-reported diagnoses of food allergies associated with fecundability, the per-cycle probability of conception?Summary answerFecundability was not appreciably associated with self-reported food allergy dia…

BackgroundDespite the fact that painful intercourse is common among reproductive-aged females, little research has evaluated how people manage painful intercourse while trying to conceive.AimTo characterize the self-reported frequency and e…

INTRODUCTION: Menstrual health is a key patient-reported outcome beyond its importance as a general indicator of health and fertility. However, menstrual function was not measured in the clinical trials of COVID-19 vaccines. The purpose of …

We examined the association between childhood adversity and fecundability (the per-cycle probability of conception), and the extent to which childhood social support modified this association. We used data from 6318 female participants aged…

Study questionTo what extent do self-reported sleep duration and non-daytime work schedules in either partner affect the rate of spontaneous abortion (SAB)?Summary answerIncidence of SAB had little association with female sleep duration and…

BackgroundThe use of fertility indicators to predict ovulation has largely been studied for contraceptive purposes, while less so as fertility-promoting tools.ObjectiveTo investigate the association between fertility indicators and fecundab…

Study questionTo what extent is preconception maternal or paternal coronavirus disease 2019 (COVID-19) vaccination associated with miscarriage incidence?Summary answerCOVID-19 vaccination in either partner at any time before conception is n…

ObjectiveTo assess the effect of randomization to FertilityFriend.com, a mobile computing fertility-tracking app, on fecundability.DesignParallel non-blinded randomized controlled trial nested within the Pregnancy Study Online (PRESTO), a N…

Few studies have evaluated the association between periodontitis and spontaneous abortion (SAB), and all had limitations. We used data from the Pregnancy Study Online (PRESTO), a prospective preconception cohort study of 3,444 pregnancy pla…

Some studies indicate that Black women have higher exposure to multiple non-persistent endocrine disrupting chemicals (EDCs) than white women, but little is known about correlates of exposure to EDC mixtures. Using baseline data from a pros…

BackgroundDepression and anxiety are prevalent among women with uterine fibroids (UF). The rate of mental health diagnoses in women with UF has not been studied.MethodsWomen aged 18-50 years with diagnosed UF were identified in the Optum Cl…

OBJECTIVE: Fibroid treatments that have few side-effects and can preserve fertility are a clinical priority. We studied the association between serum vitamin D and uterine fibroid growth, incidence, and loss. DESIGN: A prospective community…

STUDY QUESTION: How accurately do women report a diagnosis of endometriosis on self-administered questionnaires? SUMMARY ANSWER: Based on the analysis of four international cohorts, women self-report endometriosis fairly accurately with a >…

(Abstracted from Hum Reprod 2021;36:1268–1278) Approximately 10% of reproductive-aged women are affected by endometriosis, a condition in which endometrial-like tissue is found outside of the uterus causing severe pain and infertility. Diag…

PurposeAsthma has been positively associated with irregular menses and infertility in some studies, but data are limited on the relation between asthma medication use and fecundability (i.e., average per-cycle probability of conception amon…

BackgroundUterine leiomyomata (UL) are the leading indication for hysterectomy in the United States. Dietary supplementation with lycopene was associated with reduced size and incidence of oviduct leiomyoma in the Japanese quail. Two US pro…

ObjectiveTo quantify the frequency of use of selected fertility awareness indicators and to assess their influence on fecundability.DesignWeb-based prospective cohort study.SettingNot applicable.Patient(s)Female pregnancy planners, aged 21-…

The association between dietary fat and fertility is not well studied. We evaluated intakes of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, trans fatty acids (TFA), ω-3 fatty acids, and ω-6 fat…

BackgroundThe synthetic solvent tetrachloroethylene (PCE), commonly used in dry cleaning operations, is a human neurotoxicant and carcinogen. However, its effect on reproduction is poorly understood, as prior studies have been limited to sm…

Study questionDoes inverse probability weighting (IPW) provide a more valid estimate of the cumulative incidence of live birth after multiple cycles of IVF?Summary answerIPW can provide a more accurate estimate of treatment success for coun…