Human reproduction (Oxford, England)

Study questionWhat is the effect of progesterone administered via vaginal oil capsules versus pessaries, on clinical outcomes, when used for luteal phase support (LPS) in ART?Summary answerOur study findings indicate a higher live birth rat…

Study questionDo the genetic and clinical outcomes of monopronuclear blastocysts (MPBs) differ between standard insemination and intracytoplasmic sperm injection cycles, and what do these differences imply for risk stratification and indivi…

Study questionDoes anti-Müllerian hormone (AMH) influence preantral follicle development within a short range of AMH-secreting antral follicles?Summary answerImmunization of sheep against AMH leads to increased follicle survival, specifical…

Study questionIs the live birth rate higher for cleavage stage embryos compared to blastocysts in patients with a single zygote following oocyte fertilization using IVF or ICSI?Summary answerAmong patients with only a single zygote, transfe…

Study questionIs the endometrial microbiome altered in women who fail to get pregnant after ART and do microbial-derived metabolites influence endometrial cellular mechanisms important for embryo implantation?Summary answerThe endometrial m…

Study questionDoes ICSI improve the live birth rate in couples without severe male factor infertility compared to conventional IVF (cIVF)?Summary answerHigh-quality evidence showed no benefit of ICSI over cIVF in improving live birth or cum…

Study questionWhat are experiences of infertility-related traumatic events and are these associated with symptoms of Post-Traumatic Stress Disorder (PTSD) and Complex PTSD (CPTSD)?Summary answerInfertility-related trauma results from the in…

Study questionWhat is the association between treated (ART, ovulation induction (OI)) and untreated subfertility and risk of cerebral palsy (CP)?Summary answerThere is no increased risk of CP in births to subfertile untreated women; the ris…

Study questionDoes endometrial gene expression change across consecutive cycles and after endometrial injury?Summary answerAlthough paired endometrial samples collected from the same woman across two consecutive cycles show greater similari…

Recent advances in the development of stem-cell-based embryo models and endometrial assembloids have fuelled understanding of their respective biology. However, a faithful combined approach is required to truly advance our understanding of …

Study questionWhat is the effect of Virtual Reality (VR) on anxiety and pain during oocyte retrieval in IVF/ICSI treatment?Summary answerThere is no significant effect of VR on anxiety and pain during oocyte retrieval in IVF/ICSI treatment.…

Study questionWhat is the recommended prevention, diagnosis, and treatment of infertility among individuals and couples?Summary answerThe World Health Organization (WHO) made 40 recommendations and six good practice statements for the preve…

Study questionWhat updates of the International Glossary on Infertility and Fertility Care are required, to reflect contemporary scientific knowledge, social needs, and inclusive definitions, while harmonizing international communication ac…

Study questionTo what extent is male physical activity (PA) associated with fecundability (per-cycle probability of conception)?Summary answerPreconception levels of vigorous, moderate, or total PA were not consistently associated with fecu…

Study questionWhat is the association between infertility with or without fertility treatment and incident onset of systemic autoimmune rheumatic disease (SARD) among women who give birth?Summary answerWomen who experienced infertility but …

Study questionIs the probability of pregnancy different between women using biosimilars versus the originator of follitropin alfa for ovarian stimulation in ART?Summary answerMeta-analysis of eight randomized clinical trials (RCTs) suggests…

Study questionHow does two-consecutive single embryo transfer (2xSET) affect reproductive outcomes of IVF and ICSI compared to double embryo transfer (DET)?Summary answerTwo-consecutive SET may provide greater or comparable live birth rate …

Study questionWhich research topics in the area of infertility should be prioritized in the allocation of research resources?Summary answerTwelve research priorities were formulated, spanning the following areas: preventing infertility and …

Study questionDoes definitive occlusion of uterine arteries have a short- or long-term impact on ovarian reserve markers in reproductive-age women undergoing laparoscopic myomectomy?Summary answerPreventive definitive uterine artery occlusi…

Study questionWhat is the incidence of and risk factors for monozygotic twinning (MZT) following single embryo transfer (SET) in ART cycles in Australia and New Zealand?Summary answerMZT occurred in 1.5% of live births following SET, with b…

Study questionWhat number of oocytes retrieved is associated with the highest cumulative live birth rates (CLBRs) in the fresh and subsequent frozen cycles following ovarian stimulation with follitropin delta?Summary answerThe CLBR increase…

Study questionHow do ovarian responses using conventional dosing for follitropin delta 15 µg/day compare with follitropin alfa 225 IU/day in women undergoing ovarian stimulation?Summary answerThe ADAPT-1 trial demonstrates similar ovarian r…

Study questionCan algorithms using wrist temperature, available on compatible models of iPhone and Apple Watch, retrospectively estimate the day of ovulation and predict the next menses start day?Summary answerAlgorithms using wrist tempera…

Study questionTo what extent are there racial and ethnic disparities in fecundability in North America?Summary answerIn a North American preconception cohort study, we observed large differences in fecundability across racial and ethnic gro…

Study questionDoes the use of virtual reality (VR) reduce pain levels experienced by women during transvaginal oocyte retrieval using paracervical block and conscious sedation?Summary answerThe use of VR did not reduce pain levels during oo…