Zhengchen Guo

No ORCID on file · 13 papers in corpus · active 2020-2024

Study types

  • article 8
  • preprint 3
  • other 2

Condition tags

  • adenomyosis 10
  • endometriosis 4
  • mesh:D004715 2
  • dysmenorrhea 2
  • infertility 2
  • endometrioma 2
  • chronic_pelvic_pain 1
article 2024
Comprehensive analysis of circRNA-miRNA-mRNA regulatory network and novel potential biomarkers in eutopic endometrium of adenomyosis
Genomics ·doi:10.1016/j.ygeno.2024.110877

Adenomyosis (ADS) is a common gynecological disorder, and its pathogenesis remains unclear. This study explores the functions of circRNAs in the eutopic endometrium of ADS and their diagnostic efficacy for ADS. High-throughput RNA sequencin…

article 2023
Endometrial microbiota in women with and without adenomyosis: A pilot study
Frontiers in microbiology ·doi:10.3389/fmicb.2023.1075900

Introduction The endometrial microbiota plays an essential role in the health of the female reproductive system. However, the interactions between the microbes in the endometrium and their effects on adenomyosis remain obscure. Materials an…

article 2023
miR-141-3p Regulates the Proliferation and Apoptosis of Endometrial-Myometrial Interface Smooth Muscle Cells in Adenomyosis Via JAK2/STAT3 Pathway
Biochemical genetics ·doi:10.1007/s10528-023-10508-4
article 2023
Reproductive outcomes and risk factors of women with septate uterus after hysteroscopic metroplasty
Frontiers in endocrinology ·doi:10.3389/fendo.2023.1063774

Background Hysteroscopic metroplasty of the uterine septum has been the standard treatment strategy to improve reproductive outcomes, but there are still controversies about the appropriateness of metroplasty. In addition, there have been f…

other 2022
RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial-myometrial interface
BMC women's health ·doi:10.1186/s12905-022-01871-2

BACKGROUND: Uterine adenomyosis is associated with chronic pelvic pain, abnormal uterine bleeding, and infertility. The pathogenesis of adenomyosis is still unclear. Circular RNAs (circRNAs) have been implicated in several benign diseases a…

preprint 2021
Expression of BDNF and TrKB in Endometriosis and Dysmenorrhea
·doi:10.21203/rs.3.rs-625937/v1

Abstract Background: Brain-derived neurotrophic factor (BDNF) has been recognized as a regulator in the formation and maintenance of chronic pain in various chronic disorders. BDNF together with its high-affinity tyrosine kinase type B (Trk…

preprint 2021
Expression of BDNF and TrKB in Patients With Endometriosis and Their Correlation With Dysmenorrhea
·doi:10.21203/rs.3.rs-786503/v1

Abstract Background: Brain-derived neurotrophic factor (BDNF) has been recognized as a regulator in the formation and maintenance of chronic pain in various chronic disorders. BDNF together with its high-affinity tyrosine kinase type B (Trk…

article 2021
Talin1 Induces Epithelial-Mesenchymal Transition to Facilitate Endometrial Cell Migration and Invasion in Adenomyosis Under the Regulation of microRNA-145-5p
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-020-00444-8
other 2021
The cannabinoid receptor CB1 affects the proliferation and apoptosis of adenomyotic human uterine smooth muscle cells of the junctional zone: a mechanism study
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-020-00690-0

BACKGROUND: The denomyotic junctional zone (JZ) plays an important role in the pathogenesis of adenomyosis. Proliferating cell nuclear antigen (PCNA) is an important nuclear marker of cell proliferation. This study aimed to evaluate the eff…

article 2021
Upregulated Talin1 synergistically boosts β-estradiol-induced proliferation and pro-angiogenesis of eutopic and ectopic endometrial stromal cells in adenomyosis
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-021-00756-7

Abstract Adenomyosis (ADS) is an estrogen-dependent gynecological disease with unspecified etiopathogenesis. Local hyperestrogenism may serve a key role in contributing to the origin of ADS. Talin1 is mostly identified to be overexpressed a…

preprint 2021
Upregulated Talin1 Synergistically Boosts β-estradiol-induced Proliferation and Pro-angiogenesis of Eutopic and Ectopic Endometrial Stromal Cells in Adenomyosis
·doi:10.21203/rs.3.rs-181716/v1

Abstract Adenomyosis (ADS) is an estrogen-dependent gynecological disease with unspecified etiopathogenesis. Local hyperestrogenism may serve a central role in contributing the origin of ADS. Talin1 is mostly identified to be overexpressed …

article 2020
Discovery of gene module acting on ubiquitin-mediated proteolysis pathway by co-expression network analysis for endometriosis
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2020.10.005
article 2020
[Expression and significance of chemokine CXCL12 and receptor CXCR4 in adenomyosis].
Zhonghua fu chan ke za zhi ·doi:10.3760/cma.j.cn112141-20200226-00140

The levels of CXCL12 and CXCR4 in the endometrium and myometrium of adenomyosis are increased and positively correlated. The two chemokine may be involved in the development of adenomyosis.