Recently, much evidence has indicated that sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) play a role in the intracellular action of sex steroids in target cells. In the present work, expression of SHBG mRNA a…
To understand the mechanism of biological action of gestrinone (R2323), which has a therapeutic effect against endometriosis, the binding of gestrinone to numerous classes of intracellular steroid binding proteins was studied in the human u…
Abstract Nine patients with pelvic endometriosis were treated with gestrinone in a dose of 2.5 mg twice weekl‐ for 6 to 7 months. All patients became anovulator‐ with sporadic episodes of painless uterine bleeding lasting various periods of…
To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, proges…
Abstract The relation between serum hormone levels, endometrial cellular steroid receptor levels and endometrial dating was evaluated in the mid‐luteal phase of normoprolactinemic and hyperprolactinemic women for a better understanding of l…
This study was designed to clarify the effects of danazol on levels of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, progesterone (P), and 17 beta-estradiol and endometrial steroid receptors (for estrogen [E…