Levels of sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) messenger ribonucleic acid (mRNAs) in ovarian endometriosis

R Misao, Ryou Misao, Masashi Hori, M Hori, Satoshi Ichigo, S Ichigo, J Fujimoto, Jiro Fujimoto, T Tamaya
Reproduction, nutrition, development · 1995 · vol. 35(2) , pp. 155–165 · doi:10.1051/rnd:19950204 · PMID:7734053 · W2071995248
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Abstract

― Recently, much evidence has indicated that sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) play a role in the intracellular action of sex steroids in target cells. In the present work, expression of SHBG mRNA and CBG mRNA was demonstrated in tissues of human normal endometrium and pelvic endometriosis, using the reverse transcription-polymerase chain reaction (RT-PCR). SHBG mRNA levels were higher in pelvic endometriosis than in normal endometrium (P < 0.02), while CBG mRNA levels were lower than in normal endometrium (P < 0.05). The SHBG mRNA/CBG mRNA ratio was significantly higher in pelvic endometriosis than in normal endometrium (P < 0.01 These findings suggest that overexpression of intercellular SHBG in endometri- otic tissues results in the formation of the estrogen-predominant milieu, since SHBG-bound estrogen is considered to be protected from the metabolism in liver and available in endometrial cells, thereby assisting the development of the pelvic endometriosis. sex hormone-binding globulin / corticosteroid-binding globulin / mRNA I endometriosis Rsum ― Niveaux des ARN messagers de la globuline liant la testostrone (ARNm SHBG) et de la transcortine (CBG) dans l'endomtriose ovarienne. Rcemment, plusieurs travaux ont mon- tr que la SHBG et la CBG jouent un rle dans l'interaction intracellulaire de strodes sexuels dans les cellules cibles. Dans cette tude, l'expression des ARNm de la SHBG et de la CBG a t mise en vidence dans des biopsies d'endomtre humain normal et des prlvements d'endomtriose pelvienne par transcription rverse puis amplification en chane par la polymrase. La concentration de I ARNm SHBG est plus leve dans l'endomtriose pelvienne que dans l'endomtre normal (P < 0,02), les rsultats inverses sont observs pour IARNm CBG (P < 0,05). Le rapport ARNm SHBG/ARNm CBG est significativement plus lev dans l'endomtriose pelvienne que dans l'endomtre normal (P < 0, 01). tant donn que 'œstrogne li la SHBG semble tre protg du mtabolisme hpatique et rendu disponible dans les cellules endomtriales, toutes ces constatations suggrent que, dans les tissus d'endomtriose, l'augmentation de l'expression de la SHBG intracellulaire produisant un milieu o l'cestrogne est prdominant accentuerait un dveloppement de l'endomtriose pelvienne. globuline liant les hormones strodes sexuels / transcortine lARNm / endomtriose

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovary RNA, Messenger Sex Hormone-Binding Globulin Transcortin Adult Base Sequence Endometriosis Endometrium Endometrium Female Humans Molecular Sequence Data Ovary Polymerase Chain Reaction RNA, Messenger Sex Hormone-Binding Globulin Transcortin

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