Large ovarian endometriomas are associated with high pre-operative anti-Müllerian hormone concentrations

Roman H, Horace Roman, Isabella Chanavaz-Lacheray, Isabella Chanavaz‐Lacheray, Chanavaz-Lacheray I, Oana Mircea, Mircea O, Benoit Berby, Benoît Berby, Berby B, Lise Dehan, Dehan L, Sophia Braund, Braund S, Verspyck E, Eric Verspyck, Éric Verspyck, Lucian Pușcașiu, Lucian Puscasiu, Puscasiu L
Reproductive BioMedicine Online · 2020 · vol. 42(1) , pp. 158–164 · doi:10.1016/j.rbmo.2020.09.008 · PMID:33060013 · W3085883915
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Large ovarian endometriomas are associated with high pre-operative anti-Müllerian hormone concentrations.

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Abstract

RESEARCH QUESTION: Are large ovarian endometriomas associated with high pre-operative anti-Müllerian hormone (AMH) concentrations? DESIGN: Data from 332 women who underwent AMH measurement before surgery for endometriosis were prospectively recorded in a large database. Univariate analysis compared AMH concentrations in terms of the patients' baseline characteristics. A multivariate model was used to identify variables having an independent relationship with AMH concentration. RESULTS: Among 332 women included in the study, 47.6% were aged 18-30 years, 67.8% were infertile and 85.5% were nulliparous. A total of 66.3% had ovarian endometriomas, and 10.8% had cysts measuring over 6 cm. Bilateral cysts over 3 cm were recorded in 24.7% of the women. Univariate analysis identified two variables that had a statistically significant relationship with AMH concentration: the woman's age (P = 0.01) and cyst size (P < 0.001). Multivariate analysis revealed that ages of 36-40 years and over 40 years showed a significant association with lower AMH concentrations (P = 0.02 and P = 0.009, respectively), while a cyst size of over 6 cm was statistically associated with high AMH concentrations (P < 0.001), after adjustment for smoking, parity, rectosigmoid endometriotic nodules and a bilateral location of endometriomas. CONCLUSIONS: Pre-operative AMH concentration was significantly increased in women with large endometriomas of over 6 cm, independent of their age or the presence of bilateral endometriomas. This is relevant for both surgeons and patients when planning surgery in women with an intention to conceive post-operatively.

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Condition tags

endometriosis

MeSH descriptors

Anti-Mullerian Hormone Endometriosis Ovarian Diseases Adult Adult Anti-Mullerian Hormone Anti-Mullerian Hormone Endometriosis Endometriosis Endometriosis Female Female Humans Humans Ovarian Diseases Ovarian Diseases Ovarian Diseases Ovarian Reserve Ovarian Reserve Retrospective Studies

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