Serum antimüllerian hormone concentration increases with ovarian endometrioma size

Louis Marcellin, Santulli P, Piétro Santulli, Pietro Santulli, Mathilde Bourdon, Bourdon M, Clémence Comte, Comte C, Maignien C, Chloé Maignien, Just PA, Pierre Alexandre Just, Streuli I, Isabelle Streuli, Bruno Borghese, Charles Chapron, Chapron C
Fertility and sterility · 2019 · vol. 111(5) , pp. 944–952.e1 · doi:10.1016/j.fertnstert.2019.01.013 · PMID:30878253 · W2921100151
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found a positive correlation between serum antimüllerian hormone levels and the size of ovarian endometriomas in women.

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Abstract

ObjectiveTo examine whether serum antimüllerian hormone (AMH) levels correlate with the size of ovarian endometrioma (OMA).DesignAn observational cross-sectional study.SettingUniversity hospital.Patient(s)Two hundred and sixty-seven nonpregnant women, aged 18-42 years, with no prior history of surgery for endometriosis and a histologically documented ovarian cyst.Intervention(s)Surgical management for a benign ovarian cyst.Main outcome measure(s)Correlation between serum AMH concentration and cyst size according to OMA and non-OMA benign cyst.Result(s)Women with OMA were compared with a control group of women who had non-OMA benign ovarian cysts. The AMH assay samples were collected less than a month before the surgery. Between January 2004 and September 2016, 148 women were allocated to the OMA group and 119 to the non-OMA benign cyst group. The AMH concentrations were not statistically significantly different between the two groups (3.7 ± 2.8 ng/mL vs. 4.1 ± 3.3 ng/mL). A multiple linear regression model accounting for potential confounders revealed that the log10 of the serum AMH concentration positively correlated with the log10 of the OMA cyst volume (R2 = 0.23; coefficient = 0.05; 95% CI, 0.007-0.10).Conclusion(s)In women no prior history of surgery for endometriosis, serum AMH levels increased with cyst size in cases of OMA.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Anti-Mullerian Hormone Endometriosis Endometriosis Ovarian Cysts Ovarian Cysts Adolescent Adult Anti-Mullerian Hormone Biomarkers Biomarkers Cohort Studies Cross-Sectional Studies Endometriosis Endometriosis Female Humans Ovarian Cysts Ovarian Cysts Ovary Ovary

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References (53)

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