An Analysis of ESR2 and CYP19A1 Gene Expression Levels in Women With Endometriosis

Tomasz Szaflik, Beata Smolarz, Smolarz B, Mroczkowska B, Beata Mroczkowska, Bartosz Kulig, Kulig B, Malwina Soja, Soja M, Hanna Romanowicz, Romanowicz H, Magdalena Bryś, Ewa Forma, Krzysztof Szyłło, SzyŁŁo K
In vivo (Athens, Greece) · 2020 · vol. 34(4) , pp. 1765–1771 · doi:10.21873/invivo.11970 · PMID:32606145 · PMC7439897 · W3040298195
article OA: diamond CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study analyzed ESR2 and CYP19A1 gene expression in endometriosis patients and controls, finding higher ESR2 expression in patients and CYP19A1 expression associated with specific endometriosis manifestations.

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Abstract

AIM: The analysis of oestrogen receptor (ESR2) and cytochrome P450 family 19 subfamily A member (CYP19A1) gene expression in the context of the risk for endometriosis development. MATERIALS AND METHODS: Tissue specimens, collected from patients with endometriosis (n=100) and from control patients (n=100) embedded into paraffin blocks, provided the material for genetic studies, oriented towards the expression of ESR2 and CYP19A1 genes. The gene expression was assessed by the reverse transcription-polymerase chain reaction technique. RESULTS: Higher expression levels of ESR2 gene were demonstrated in the patients with endometriosis in comparison with the healthy controls. The expression intensity of CYP19A1 gene was associated with endometriosis, manifested as abdominal wall nodules. A relationship was observed between CYP19A1 gene expression and the Revised American Society for Reproductive Medicine classification in the group with ovarian endometrioid cysts, as well as in the group with peritoneal endometriosis. CONCLUSION: This study suggests the significant role of ESR2 and CYP19A1 gene expression in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Aromatase Aromatase Endometrium Estrogen Receptor beta Estrogen Receptor beta Female Gene Expression Humans Promoter Regions, Genetic

Citation neighborhood

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References (21)

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