Endométriose : pourquoi se développe-telle ?

Aude Béliard, Jean-Michel Foidart, Michelle Nisolle
In: Références en Gynécologie Obstétrique, 14, 1-5 (2012) · 2012 · vol. 14 · W2278868279
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New findings regarding genetics, environment, the immune system, and inflammation provide insight into the pathogenesis of estrogen-dependent endometriosis, paving the way for novel treatments and diagnostics.

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This 2012 peer-reviewed article discusses why endometriosis develops, framing the condition as estrogen-dependent and associated with substantial morbidity including pelvic pain and multiple operations. It synthesizes emerging evidence on the roles of genetics, possible environmental influences, the immune system, and inflammation in endometriosis pathogenesis. The caveat is that it is presented as a perspective/review-style synthesis rather than presenting new original experimental results, and it positions findings as a basis for potential therapeutic and less invasive diagnostic directions. This paper is centrally about endometriosis — it focuses on the mechanisms (genetic, immune, inflammatory, environmental) proposed to explain its development.

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Keywords

Endométriose; Système immunitaire; inflammation; Génétique; Facteurs de l’environnement; Endometriosis; Immune system; Genetics; Environmental factors

Abstract

[fr] L’endométriose est une maladie œstrogéno-dépendante responsable d’une morbidité importante liée notamment aux opérations multiples et aux phénomènes douloureux. De nouvelles données sur les facteurs génétiques, le rôle possible de l’environnement, du système immunitaire, de l’inflammation offrent des nouvelles perspectives concernant la physiopathogénie de cette affection permettant ainsi de nouvelles approches thérapeutiques et d’autres voies pour un diagnostic moins invasif que la cœlioscopie exploratrice. [en] Endometriosis is an estrogen-dependent disorder that can result in substantial morbidity, including multiple operations, and pelvic pain. New findings on the genetics, the possible roles of the environment, the immune system, and the inflammation have given insight into the pathogenesis of this disorder and serve as the background for new treatments and new diagnostic approach. [en] Endometriosis is an estrogen-dependent disorder that can result in substantial morbidity, including multiple operations, and pelvic pain. New findings on the genetics, the possible roles of the environment, the immune system, and the inflammation have given insight into the pathogenesis of this disorder and serve as the background for new treatments and new diagnostic approach. Disciplines : Reproductive medicine (gynecology, andrology, obstetrics) BELIARD, Aude ; Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique Nisolle, Michelle ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique Language : English Title : Endométriose : pourquoi se développe-telle ? Publication date : 2012 Journal title : Références en Gynécologie Obstétrique ISSN : 1244-8168 Publisher : Springer, Germany Volume : 14 Pages : 1-5 Peer reviewed : Peer reviewed Available on ORBi : since 05 February 2013

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