Endometrial stem/progenitor cells

Maruyama T, Tetsuo Maruyama
Journal of Obstetrics and Gynaecology Research · 2014 · vol. 40(9) , pp. 2015–2022 · doi:10.1111/jog.12501 · PMID:25160689 · W1502139054
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Human endometrium harbors stem/progenitor cells that drive cyclical regeneration and remodeling, and may contribute to associated disease pathogenesis.

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Abstract

Human endometrium regenerates and regresses with each menstrual cycle under hormonal control throughout a woman's reproductive life. The cyclical regeneration and remodeling potentials allude to the existence of stem/progenitor cells in the endometrium. There is increasing evidence that human endometrium contains small numbers of stem-like cells capable of self-renewal, multiple differentiation and tissue reconstitution. Although the precise identity of endometrial stem/progenitor cells remains elusive, these cells are thought to play pivotal role(s) in the physiological remodeling and regeneration of the human endometrium and also in the pathogenesis of endometrium-associated diseases, such as endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Adult Stem Cells Endometrium Menstrual Cycle Menstrual Cycle Models, Biological Models, Biological Adult Adult Adult Stem Cells Adult Stem Cells Adult Stem Cells Animals Animals Cell Movement Cell Movement Endometriosis Endometriosis Endometriosis Endometrium Endometrium

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References (50)

Cited by (9)

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