Risk factors for external genital endometriosis

V.O. Chervov, N.V. Artymuk, Лариса Николаевна Данилова
In: Acta Biomedica Scientifica · 2018 · vol. 3(3) , pp. 54–58 · doi:10.29413/abs.2018-3.3.8 · W2956862291
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This case-control study identified early menarche, short and prolonged menstrual cycles, smoking, furnace heating, uterine fibroids, and a family history of breast cancer as risk factors for external genital endometriosis.

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The paper reviews and synthesizes evidence on risk factors for external genital (i.e., non–deep infiltrating/internal) endometriosis, drawing on a set of cited studies addressing reproductive history, body size and BMI, menstrual characteristics, tobacco smoking, and other lifestyle or hormonal/toxicant-related exposures. The authors discuss how study population differences matter for characterizing endometriosis risk, alongside reported associations from cohort and case-control work as well as meta-analyses. A key limitation is that the included evidence spans different designs and populations, which complicates direct comparison of risk estimates across studies. Relevance to endometriosis: this paper’s topic is explicitly external genital endometriosis risk-factor synthesis, aligning with endometriosis research focused on identifying determinants of disease occurrence and variation.

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Abstract

One of the most common forms of violation of the reproductive system of a woman is endometriosis. It is assumed that the genetic predisposition and environmental factors are closely related to the development of endometriosis. However, despite the high prevalence of endometriosis among women of reproductive age, the risk factors or markers for the development of the disease remain largely unknown. The aim of the study was to identify risk factors for external genital endometriosis. Materials and methods. Study design: retrospective case-control. The study included 154 women. Group I included 77 women with histologically verified external genital endometriosis. Group II consisted of 77 women without endometriosis, who underwent endoscopic surgery due to various diseases of the pelvic organs. Results. The results of the study showed that the most significant risk factors for endometriosis are the early onset of menarche (< 11 years), a shortened menstrual cycle with prolonged menstruation, active and passive smoking, the presence of furnace heating and uterine fibroids, a family history of breast cancer. Typical complaints of patients with endometriosis are pelvic pain, dysmenorrhea and dyspareunia. Conclusions. Further studies are needed to study the significance of these factors in the diagnosis of endometriosis and the understanding of its etiology.
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Факторы риска наружнего генитального эндометриоза https://doi.org/10.29413/ABS.2018-3.3.8 Аннотация Об авторах В. О. ЧервовРоссия Н. В. Артымук Россия Л. Н. Данилова Россия Список литературы 1. Артымук Н.В., Данилова Л.Н., Червов В.О., Рыбников С.В. Эффективность комбинированного лечения бесплодия, ассоциированного с эндометриозом // Фарматека. - 2017. - № 12. - С. 56-61 2. Артымук Н.В., Данилова Л.Н., Червов В.О., Рыбников С.В., Тачкова О.А., Черняева В.И. Сравнительная оценка комбинированного лечения пациенток страдающих эндометриозом и бесплодием, с приминением агонистов гонадотропин-рилизинг-гормона и диеногеста // Проблемы репродукции. - 2017. -Т. 23. - № 2. - С. 61-65 3. Артымук Н.В., Елизарова Н.Н., Поленок Е.Г. Роль стероидных гормонов и химического канцерогена бензо(а)пирена в преждевременном разрыве плодных оболочек при недоношенной беременности // Гинекология. - 2017. - Т. 19, № 2. - С. 55-58 4. Ashrafi M., Sadatmahalleh S.J., Akhoond M.R., Talebi M. (2016). 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Hum Reprod, 25 (5), 1325-1334. DOI: 10.1093/humrep/deq039. 20. Wei M., Cheng Y., Bu H., Zhao Y., Zhao W. (2016). Length of menstrual cycle and risk of endometriosis: a meta-analysis of 11 case-control studies. Medicine, 95 (9), e2922. DOI: 10.1097/MD.0000000000002922 Рецензия Для цитирования: Червов В.О., Артымук Н.В., Данилова Л.Н. Факторы риска наружнего генитального эндометриоза. Acta Biomedica Scientifica. 2018;3(3):54-58. https://doi.org/10.29413/ABS.2018-3.3.8 For citation: Chervov V.O., Artymuk N.V., Danilova L.N. Risk factors for external genital endometriosis. Acta Biomedica Scientifica. 2018;3(3):54-58. (In Russ.) https://doi.org/10.29413/ABS.2018-3.3.8 JATS XML

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