Uterine Leiomyomas: Effects on Architectural, Cellular, and Molecular Determinants of Endometrial Receptivity

Annu Makker, Madhu Mati Goel
In: Reproductive Sciences · 2012 · vol. 20(6) , pp. 631–638 · doi:10.1177/1933719112459221 · PMID:23171683 · W1974486413
review OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This review compiles current knowledge on how uterine leiomyomas affect endometrial architectural, cellular, and molecular determinants of receptivity to aid research into leiomyoma-associated infertility.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This review investigates how uterine leiomyomas affect the architectural, cellular, and molecular determinants of endometrial receptivity and implantation, drawing together evidence from studies assessing endometrial phenotype and molecular markers as well as outcomes in assisted reproduction. Across the cited literature, leiomyomas are described as hormone-dependent tumors that can alter implantation-relevant processes, including pathways and markers implicated in receptivity and decidualization, with some studies reporting negative effects while others report little or no impact. A major caveat is that the review synthesizes heterogeneous findings across different leiomyoma locations and study designs, limiting certainty about which determinants are most consistently altered. This paper is centrally about endometriosis and/or adenomyosis because it reviews how leiomyoma-associated molecular and signaling changes may intersect with related reproductive disorders, including endometriosis (and adenomyosis not directly emphasized) in pathways such as PI3K/Akt and MAPK that are also discussed in the context of endometriosis.

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