A Review of the Molecular Basis for Reduced Endometrial Receptivity in Uterine Fibroids and Polyps

Shagun Narula, Amani Harris, Jim Tsaltas
In: Journal of Endometriosis and Pelvic Pain Disorders · 2017 · vol. 9(4) , pp. 239–244 · doi:10.5301/jeppd.5000304 · W2766238530
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Abstract

The presence of fibroids and endometrial polyps is associated with reduced endometrial receptivity and subsequent fertility outcomes. The following review explores the molecular mechanisms behind reduced endometrial receptivity, with a focus upon homebox genes, basic transcription element binding proteins, transforming growth factor β-3, and bone morphogenetic protein 2. A better understanding of these processes is essential for future targeted therapy.

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