Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience

Zhiqin Bu, Linli Hu, Xinhong Yang, Yingpu Sun
In: Frontiers in Endocrinology · 2020 · vol. 11 , pp. 469 · doi:10.3389/fendo.2020.00469 · PMID:33013679 · PMC7509444 · W3083091639
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that while intrauterine operations cause thin endometrium, a normal uterine cavity and endometrium lead to a better cumulative live birth rate in patients with thin endometrium.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This retrospective single-center cohort study (2015–2018) examined patients undergoing their first GnRH-agonist IVF/ICSI cycle with persistently thin endometrium (EMT <7 mm on hCG day) and used pre-transfer hysteroscopy to classify uterine status as totally normal, normal with a specific abnormality (e.g., history of adhesions/endometritis/endometrial tuberculosis/adenomyosis or fibroids), or adhesions requiring separation before transfer. Among 245 eligible patients, about 60% of thin EMT cases were attributed to an intrauterine operation, and cumulative live birth rate was 35.45% (67/189). CLBR differed significantly across uterine condition groups, with patients with normal cavity/endometrium (group A) showing higher CLBR than those with adhesions (group C), while EMT and endometrial pattern were not associated with CLBR; the paper’s main limitation is its retrospective design and reliance on single-center classification, plus exclusions that may affect generalizability. Relevance to endometriosis: adenomyosis is listed among the “normal-with a specific abnormality” uterine conditions used to stratify outcomes, and adenomyosis is therefore incorporated as an explicit factor in this endometrial-thickness/IVF outcome analysis, though the study is primarily about uterine condition categories in persistently thin endometrium.

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Abstract

Background: Studies have shown that patients with a thin endometrial thickness (EMT 5). In binary logistic regression analysis, age (OR=0.09, P=0.03), number of embryos available(OR=1.71, P=0.00), and uterine condition (OR=6.77, P=0.00 for Group A; OR=2.55, P=0.04 for Group B; Reference=Group C), were significantly associated with CLBR. However, EMT and endometrial pattern had no impact on CLBR. Conclusion: An intrauterine operation was the main reason for a thin EMT. Thin EMT patients with a normal uterine cavity and endometrium had a significantly better CLBR compared with those with adhesions before transfer.

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