Cross-Sectional Survey of the Impact of Endometriosis Symptoms on Health-Related Quality of Life in Canadian Women

Ahmed M. Soliman, Singh S, Sukhbir S. Singh, Sukhbir Singh, Yasmine Rahal, Rahal Y, Catherine Robert, Robert C, Defoy I, Isabelle Defoy, Nisbet P, Paul Nisbet, Nicholas Leyland, Leyland N
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020 · vol. 42(11) , pp. 1330–1338 · doi:10.1016/j.jogc.2020.04.013 · PMID:32758398 · W3025878961
article OA: bronze CC0 ⤵ 16 in-corpus citations
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This cross-sectional survey investigated the relationship between endometriosis symptoms and health-related quality of life in Canadian women.

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Abstract

ObjectiveTo characterize the health-related quality of life (HRQOL) of Canadian women with a self-reported diagnosis of endometriosis (DxE).MethodsCanadian women aged 18-49 years completed a survey from December 2018 through January 2019 in which HRQOL was assessed via the 12-item Short Form Health Survey (SF-12) and Endometriosis Health Profile-30 (EHP-30) questionnaire. We used t tests to compare SF-12 scores between women with and without a self-reported DxE, as well as the severity of hallmark endometriosis symptoms, including menstrual pelvic pain/cramping, non-menstrual pelvic pain/cramping, and dyspareunia, for women with a DxE (moderate/severe vs. mild/none). The effects of overall endometriosis symptom severity on HRQOL were assessed via analysis of variance.ResultsIn total, 26 528 women without a DxE and 2004 women with a self-reported DxE were included. SF-12 scores were significantly lower for women with versus without a DxE (Mental Component Summary: 38.6 vs. 41.2; Physical Component Summary: 47.3 vs. 52.1; both P < 0.001), indicating reduced HRQOL. Moderate/severe hallmark endometriosis symptoms were associated with low SF-12 scores (i.e., worse HRQOL), with the greatest impact from non-menstrual pelvic pain/cramping. EHP-30 scores for women with a DxE ranged from 40.6 to 46.8, with the greatest impairment in self-image. Women with severe endometriosis symptoms had EHP-30 scores 1.3- and >2-fold higher (i.e., worse) than those with moderate and mild symptoms, at 67.5-74.6 versus 51.3-56.9 and 25.6-32.9, respectively.ConclusionCanadian women with a self-reported diagnosis of endometriosis had significantly impaired health-related quality of life, which was inversely correlated with endometriosis symptom severity. This finding highlights a substantial unmet need among women with endometriosis.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Pelvic Pain Quality of Life Adolescent Adult Canada Canada Cross-Sectional Studies Endometriosis Endometriosis Endometriosis Female Humans Mental Health Middle Aged Pelvic Pain Pelvic Pain Quality of Life Self Concept Social Support

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