Identification of the cadherin subtypes present in the human peritoneum and endometriotic lesions: Potential role for P‐cadherin in the development of endometriosis

George T C Chen, Chin‐Tao Tai, Chin-Tao Tai, Lian-Shung Yeh, Lian‐Shung Yeh, Tung‐Chuan Yang, Tung-Chuan Yang, Horng-Der Tsai, Horng‐Der Tsai
Molecular reproduction and development · 2002 · vol. 62(3) , pp. 289–294 · doi:10.1002/mrd.10121 · PMID:12112590 · W2129254986
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This study identified multiple cadherins in the human peritoneum and endometriotic lesions, finding P-cadherin to be predominant and significantly upregulated in lesions compared to eutopic endometrium.

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Abstract

Endometriosis is defined as endometrial tissue outside of the uterine cavity. The pathogenesis of this common disease remains poorly understood. However, the implantation and invasion of the viable cells from retrograde menstruation into the peritoneum is a widely accepted theory. To date, the mechanisms by which cell adhesion molecules mediate the development of human endometriosis remain unclear. Cadherins are a family of cell adhesion molecules that mediate cell-cell adhesion in a homophilic manner. In this study, the cadherins present in the peritoneum and endometriotic lesions were identified by RT-PCR using degenerate primers. In addition, differences in the levels of the cadherin mRNA transcripts present in eutopic endometrium and endometriotic lesions of the same patients were then compared by semiquantitative RT-PCR. Multiple cadherins were detected in the peritoneum and endometriotic lesions. Of these, P-cadherin appears to be the predominant cadherin subtype present in the peritoneum. Similarly, P-cadherin mRNA levels in endometriotic lesions were significantly greater than those observed in the corresponding eutopic endometrium. The expression of P-cadherin in both the human peritoneum and endometriotic lesions suggests that this cell adhesion molecule may play a central role in the development of endometriosis by mediating endometrial-peritoneal cell interactions in a homophilic manner.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cadherins Endometriosis Peritoneum Adult Cadherins Cadherins Cadherins Endometriosis Endometriosis Endometriosis Female Humans Menstrual Cycle Menstrual Cycle Menstrual Cycle Peritoneum Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger

Citation neighborhood

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References (34)

Cited by (21)

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