P-Cadherin Expression in Human Endometrium and Endometriosis

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AI-generated summary by claude@2026-06, 2026-06-07

P-cadherin was detected in endometrial epithelial cells and endometriotic glandular structures, exhibiting similar staining patterns to E-cadherin, suggesting a role in maintaining proliferative compartments.

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Abstract

The objective of the present study was to detect the expression of P-cadherin in human endometrium and endometriosis and to compare this expression to that of E-cadherin. To this end immunohistochemistry with monoclonal antibodies specific for P-cadherin and E-cadherin was applied to endometrium and endometriotic lesions obtained in the early follicular phase of the menstrual cycle from 10 patients. P-cadherin was detected in epithelial cells in all ten endometrial samples and in all glandular structures of endometriotic lesions. The staining characteristics for P-cadherin and E-cadherin were similar. P-cadherin may play a role in the maintenance of the proliferative compartment of endometrium and could have a comparable function in endometriotic lesions.

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Condition tags

endometriosis

MeSH descriptors

Cadherins Endometriosis Endometrium Cadherins Endometrium Female Humans

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Cited by (15)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:29.222973+00:00
License: CC0 · commercial use OK