Pre or post-operative medical treatment with nafarelin in stage III-IV endometriosis: a French multicenter study

A Audebert, Audebert A, Philippe Descamps, Descamps P, P. Descamps, H. Marret, Marret H, Ory-Lavollee L, L Ory-Lavollee, L. Ory‐Lavollée, François Bailleul, F Bailleul, Bailleul F, S. Hamamah, Hamamah S
European journal of obstetrics, gynecology, and reproductive biology · 1998 · vol. 79(2) , pp. 145–148 · doi:10.1016/s0301-2115(98)00028-1 · PMID:9720832 · W2058175658
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This multicenter study investigated the efficacy of nafarelin treatment administered either before or after surgery for stage III-IV endometriosis.

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Abstract

OBJECTIVES: To determine the effectiveness of a 6-month course of nafarelin in the treatment of stage III-IV endometriosis and to determine if pre-operative use of nafarelin facilitates surgery. DESIGN: Prospective, multicenter, clinical trial. SETTING: Eight university hospitals and two private practice institutions in France. PATIENTS: Fifty-five patients with stage III and IV endometriosis. Two were excluded. INTERVENTIONS: The severity of endometriosis was assessed at the time of laparoscopy and patients were randomized to have either laparosopic surgery at that time following 6 months of nafarelin therapy (n=28), or laparoscopic surgery following 6 months of nafarelin therapy (n=25). All had 200 microg intranasal nafarelin twice a day for 6 months and a second look laparoscopy. MAIN OUTCOME MEASURE: Clinical efficacy, tolerance to the treatment. RESULTS: Efficacy and tolerance to the treatment were the same in both groups. AFS scores compared on both laparoscopies were significantly better if nafarelin was given prior to surgery (P=0.007). CONCLUSIONS: This preliminary study shows that in cases of combined medico-surgical treatment for stage III-IV endometriosis, preoperative medical treatment with GnRH-a gives a better AFS score improvement, but no conclusion was possible whether preoperative treatment facilitates surgery.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Hormones Nafarelin Adult Adult Double-Blind Method Double-Blind Method Endometriosis Endometriosis Female Female Hormones Hormones Humans Humans Laparoscopy Laparoscopy Nafarelin Nafarelin Nafarelin

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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