Laparoscopic ablation or excision with helium thermal coagulator versus electrodiathermy for the treatment of mild-to-moderate endometriosis: randomised controlled trial

Misra G, G Misra, Julius Sim, Z El-Gizawy, El-Gizawy Z, Zeiad El-Gizawy, Watts K, Keira Watts, K Watts, Jerreat S, S Jerreat, T Coia, Coia T, J Ritchie, Ritchie J, Joanne Ritchie, S O'Brien, O'Brien S, S. O’Brien
BJOG: An International Journal of Obstetrics & Gynaecology · 2020 · vol. 127(12) , pp. 1528–1535 · doi:10.1111/1471-0528.16279 · PMID:32340075 · W3020001948
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Laparoscopic treatment of mild-to-moderate endometriosis with electrodiathermy resulted in statistically lower cyclical pain and dyspareunia scores compared to helium thermal coagulation.

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Abstract

OBJECTIVE: To compare electrodiathermy with helium thermal coagulation in laparoscopic treatment of mild-to-moderate endometriosis. DESIGN: Parallel-group randomised controlled trial. SETTING: A UK endometriosis centre. POPULATION: Non-pregnant women aged 16-50 years with a clinical diagnosis of mild-to-moderate endometriosis. METHODS: If mild or moderate endometriosis was confirmed at laparoscopy, women were randomised to laparoscopic treatment with electrodiathermy or helium thermal coagulator. MAIN OUTCOME MEASURES: Cyclical pain and dyspareunia (rated on a 100-mm visual analogue scale, VAS), quality of life at baseline and at 6, 12 and 36 weeks following surgery, operative blood loss and surgical complications. RESULTS: A total of 192 women were randomised. Of these, 155 (81%) completed the primary outcome point at 12 weeks. In an intention-to-treat analysis, VAS scores for cyclical pain were significantly lower in the electrodiathermy group compared with the helium group at 12 weeks (mean difference, 9.43 mm; 95% CI 0.46, 18.40 mm; P = 0.039) and across all time points (mean difference, 10.13 mm; 95% CI 3.48, 16.78 mm; P = 0.003). A significant difference in dyspareunia also favoured electrodiathermy at 12 weeks (mean difference, 11.66 mm; 95% CI 1.39, 21.93 mm; P = 0.026). These effects were smaller than the proposed minimum important difference of 18.00 mm, however. Differences in some aspects of quality of life favoured electrodiathermy. There was no significant difference in operative blood loss (fold-change with helium as reference, 1.43; 95% CI 0.96, 2.15; P = 0.081). CONCLUSIONS: Although electrodiathermy was statistically superior to helium ablation in reducing cyclical pain and dyspareunia, these effects may be too small to be clinically significant. TWEETABLE ABSTRACT: Helium coagulation is not superior to electrodiathermy in laparoscopic treatment of mild-to-moderate endometriosis.

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Outcome instruments

VAS-pain

Condition tags

endometriosisdyspareunia

MeSH descriptors

Ablation Techniques Electrocoagulation Electrocoagulation Electrocoagulation Endometriosis Laparoscopy Laparoscopy Ablation Techniques Ablation Techniques Adolescent Adolescent Adult Adult Double-Blind Method Double-Blind Method Endometriosis Endometriosis Female Female Helium

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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