Anastrozole and Levonorgrestrel-Releasing Intrauterine Device in the Treatment of Endometriosis: A Randomized Clinical Trial.

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Pedro Acién, Irene Velasco, Maribel Acién This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-51837/v4 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 20 May, 2021 Read the published version in BMC Women's Health → Version 4 posted 9 You are reading this latest preprint version Show more versions Abstract Background: To study the effectiveness of an aromatase inhibitor (Anastrozole) associated to levonorgestrel-releasing intrauterine device (LNG-IUD, Mirena®) in the treatment of endometriosis. Methods: Prospective, randomized clinical trial. Setting: University Hospital (single center). Elegibility criteria: Endometriomas >3×4 cm, CA-125>35 U/mL and endometriosis symptoms. Patients: Thirty-one women randomized to anastrozole+Mirena®+Conservative Surgery(CS) (n=8), anastrozole+Mirena®+transvaginal ultrasound-guided puncture-aspiration (TUGPA) (n=7), Mirena®+CS (n=9), or Mirena®+TUGPA (n=7). Interventions: Anastrozole 1 mg/day and/or only Mirena® for 6 months; CS (ovarian and fertility-sparing) or TUGPA of endometriomas one month after starting medical treatment. Main Outcome Measures: Visual analogic scale for symptoms, CA-125 levels, ultrasound findings of endometriomas and recurrences. Results: A significant improvement in symptoms during the treatment (difference of 43%, 95% CI 29.9-56.2) occurred, which was maintained at 1 and 2 years. It was more significant in patients treated with anastrozole (51%, 95% CI 33.3-68.7). For CA-125, the most significant decrease was observed without anastrozole (73.8%, 95% CI 64.2-83.4 vs. 53.8%, 95% CI 25.7-81.6 under Mirena®+anastrozole). After CS for endometriosis, a reduction of findings of endometriomas and long-term recurrences occurred, with or without anastrozole. At 4,2±1,7 years (95% CI 3,57-4,85), 88% of the patients who underwent CS were asymptomatic, without medication or reoperation, compared to only 21% if TUGPA was performed, with or without anastrozole (p=0.019). Conclusions: Dosing anastrozole for 6 months, starting one month before CS of endometriosis, reduces more significantly the painful symptoms and delays recurrences, but has no other significant advantages over the single insertion of LNG-IUD (Mirena®) during the same time. Anastrozole and/or only Mirena® associated with TUGPA are not effective. Obstetrics & Gynecology Aromatase inhibitors Anastrozole levonorgestrel-IUD endometriosis endometriomas clinical trial Figures Figure 1 Figure 2 Figure 3 Figure 4 Highlights Anastrozole and LNG-IUD for 6 months improve significantly the painful symptoms of endometriosis. However, Anastrozole has no significant advantages over the single insertion of LNG-IUD (Mirena®). Anastrozole and/or Mirena® associated with puncture-aspiration of endometriomas are not very effective. Plain English Summary This was a randomized CT designed to study the effectiveness of an aromatase inhibitor (Anastrozole) associated to levonorgestrel-releasing intrauterine device (LNG-IUD, Mirena®) in the treatment of endometriosis. The eligibility criteria were presence of endometriomas >3×4 cm (ultrasound), CA-125 values >35 U/mL and endometriosis symptoms assessed with a VAS>4; and these being the main outcome measures in addition to recurrences. The interventions were 1) administration of Anastrozole 1 mg/day and/or Mirena® for 6 months; and 2) to perform conservative surgery (CS, ovarian and fertility-sparing) or transvaginal ultrasound-guided puncture-aspiration (TUGPA) of endometriomas, one month after starting medical treatment. Thirty-one women were randomized to anastrozole+Mirena®+CS (n=8), anastrozole+Mirena®+TUGPA (n=7), Mirena®+CS (n=9), or Mirena®+TUGPA (n=7). The results showed a significant improvement in symptoms during the treatment which was maintained at 1 and 2 years and that was more significant in patients treated with anastrozole, although for CA-125, the most significant decrease was observed without anastrozole. After CS, a reduction of findings of endometriomas and long-term recurrences occurred, with or without anastrozole. At 4.2 ± 1.7 years, 88% of the patients who underwent CS were asymptomatic, without medication or reoperation, compared to only 21% if TUGPA was performed, with or without anastrozole. In conclusion, dosing anastrozole for 6 months, starting one month before CS of endometriosis, reduces more significantly the painful symptoms and delays recurrences, but has no other significant advantages over the single insertion of LNG-IUD (Mirena®) during the same time. However, the medical treatments associated with TUGPA are not effective. Background The therapeutic perspectives for endometriosis have been directed in the last years towards the use of a variety of new medications including immunomodulatory agents (i.e. local interleukin-2r [1]), selective estrogen and progesterone receptor modulators, GnRH antagonist, angiogenic inhibitors, or the third-generation aromatase inhibitors (AI) (i.e. Anastrozole and Letrozole), systemically and/or locally administered, and eventually without the need for surgery [2, 3-5]. Anastrozole inhibits aromatase and decreases the amount of estrogens in all tissues; thus, in positive aromatase endometriotic implants, it should prevent local estrogenic production and, therefore, endometriotic tissue proliferation [2, 6-8]. That estrogen suppression and subsequent response from the adenohypophysis could lead to an increase in gonadotropins with consequent ovarian stimulation and possible formation of dysfunctional cysts or eventual follicular rupture, ovulation, and pregnancy. Thus, in all studies in premenopausal women with endometriosis in which long-term AIs have been used, they have been associated with gonadotropin-releasing hormone (GnRH) analogues, to slow down gonadotropins and produce hypoestronism, or with progestins or oral contraceptive pills (OCP), which could also improve endometriosis and its symptoms. An alternative as a contraceptive method could be the use of a levonorgestrel-releasing intrauterine device (LNG-IUD), such as Mirena®, a device that contains 52 mg of levonorgestrel (LNG) and releases it in situ 20 μg/24 hours. LNG induces the atrophia of eutopic endometrium that would reduce or avoid the retrograde menstruation. Based on previous reports about the use of both medications (Anastrozole [3, 4] and MirenaÒ [9]) in endometriosis patients, our therapeutical proposal was to associate Anastrozole administered orally for 6 months with Mirena® during the same time period. Furthermore, although this medical treatment (Anastrozole and/or only Mirena) could be more effective when associated to the surgical exeresis of the endometriotic foci, we wanted to clarify whether this would also be the case when associated to transvaginal ultrasound-guided puncture-aspiration (TUGPA) of the endometriomas, as we had already done in previous works associating TUGPA with analogues or leaving r-IL2 in situ [1,10,11]. Study objective : We proposed a clinical trial (CT), whose main objective was to assess the efficacy of AI Anastrozole associated with LNG-IUD (Mirena®) (compared with Mirena® alone), in the treatment of moderate and severe endometriosis and its symptoms, along with laparoscopic or laparotomic conservative surgery (CS) (ovarian and fertility-sparing), or with simple TUGPA of the endometriomas. Methods Study design . Randomized, comparative and controlled clinical trial (CT) whose protocol (ENDOMET-IA-DIULNG08) was approved by the Ethics Committee of San Juan University Hospital (26-August-2008). It was registered in the Eudra CT System of the European Medicines Agency (London, 29-Sept-2008; Nº EudraCT: 2008-005744-17) (07/11/2008) and then authorized by the Spanish Agency for Medicines and Health Products (AEMPS) (10/11/2008). Participants : Premenopausal women with endometriomas recruited at the Endometriosis and Reproductive Medicine Consultation of San Juan University Hospital. They had been advised for CS, did not currently desire pregnancy, and accepted the insertion of LNG-IUD (Mirena®) for 6 months and randomization to perform conservative surgery (CS) with ovarian and fertility-sparing by laparoscopy or laparotomy, or only transvaginal ultrasound-guided puncture-aspiration (TUGPA) of endometriomas, 1 month after the IUD insertion. Inclusion criteria : Young women ( 3×4 cm). These patients could have a previous diagnosis and treatment (medical and/or surgical) of endometriosis, but they should not have received medical treatment in the last 3 months. Exclusion criteria : i) Pregnancy; ii) Infertility with current desire for pregnancy; iii) No previous sexual intercourse and/or non-acceptance of insertion of Mirena®; iv) Acute or recurrent pelvic inflammatory disease or genital tract infection; v) Uterine malformations and/or leiomyomas; vi) Any medical pathology that could contraindicate the treatment with Anastrozole or LNG-IUD (Mirena®). Written informed consent was obtained from all patients before randomization . Participants were randomized by computer, determined at the Hospital Pharmacy after a telephone call from the Endometriosis Consultation. Between January 15, 2009 (date of inclusion of the first patient) and March 15, 2015, the eligibility criteria were analyzed in 52 patients who had ovarian cystic tumors suggestive of endometriomas, with indication to CS. After excluding 21 patients due to not meeting all the inclusion criteria, doubts in the ultrasound diagnosis, or because they declined to participate, the other 31 women were included, randomized, treated and followed up according to the following subgroups: (1) Anastrozole-Mirena-CS (n = 8); (2) Anastrozole-Mirena-TUGPA (n = 7); (3) no Anastrozole-Mirena-CS (n = 9); and (4) no Anastrozole-Mirena-TUGPA (n = 7). Procedures . Medical treatments: (1) oral Anastrozole, 1 tablet of 1 mg daily for 6 months administered to patients in subgroups 1 and 2; (2) LNG-IUD (Mirena®) for all patients; (3) calcium carbonate and cholecalciferol (Ca + Vitamin D) to patients taking Anastrozole to avoid the damaging effects of AI on the bone. Surgical treatments: (1) laparoscopy (in 13 women, 76%) or laparotomy (in 4 women -in 2 was conversion-) with CS of endometriosis; or (2) TUGPA of endometriomas (in 14 women). All surgeries were performed or directed by the first author of the present study (PA). Research plan : All patients will undergo a first analytical control, clinical exploration and TVU in the second half of the cycle, being randomized according to the subgroups previously exposed. Patients of subgroups 1 and 2 would start taking Anastrozole at the beginning of the next menstruation, placing the LNG-IUD (Mirena®) during it, as well as in the other subgroups. At the time, the surgical proposal to be practiced a month later was processed. Postoperative control follow-ups would be done at 3 and 6 months (time of withdrawal of Anastrozole and Mirena®); thereafter at 9, 12, 18, 24 months, and then annual follow-ups. Assessments . All patients must have a detailed medical history about their antecedents and previous treatments, also including clinical exploration, TVU, hormonal and tumor marker analysis (CA-125, CA-19-9) and symptoms score using our VAS [maximum 10 points, including dysmenorrhea (0-3), deep dyspareunia (0-3), chronic pelvic pain (CPP, 0-3), and others (0-1)]. In all subsequent follow-ups, TVU, analysis and VAS score for symptoms were repeated. We considered recurrence of the disease when an endometrioma was detected in any control, which persisted or grew in subsequent follow-ups, associated with an increase in VAS score and/or CA-125 level. In any case, the recurrences of small endometriomas (1.5-3 cm) and endometriomas greater than 3×4 cm are presented separately in the tables of results. Outcomes . Primary endpoint : clinical, analytical and ultrasound improvement assessed by (1) reduction or disappearance of symptoms; (2) normalization of CA-125 values; (3) reduction or disappearance of endometriomas. These parameters were studied in each postoperative control follow-up at 3 and 6 months; thereafter at 9, 12, 18, 24 months, and then in annual follow-ups. Secondary endpoints : (1) decrease or disappearance of recurrences; (2) rate of reoperations; (3) subsequent pregnancy achievement; and (4) valuation of the clinical state in the last follow-up and the need for other treatments. Safety and adverse events . In laparoscopic or laparotomic surgery, peritoneal fluid and biopsies or surgical specimens were collected for cytological and histopathological studies. In TUGPA, endometrioma fluids were also collected for cytological analysis. Side effects and adverse events were registered and considered in each patient follow-up. Statistical analysis . Sample size: Based on previously published studies using AI [3,4,12,13] or LNG-IUD [9], in the research project-protocol of the clinical trial ENDOMET-IA-DIULNG08 (EudraCT No.: 2008-005744-17) we include the following analysis: “with respect to symptoms, with the LNG-IUD we expect to find improvements of 60% and, with associating aromatase inhibitors + LNG-IUD, of 94% (p <0.05 with 16 cases in each branch). Regarding recurrence of symptoms and endometriosis, after LNG-IUD it would be foreseeable that only 20-25% will be free of recurrence in two years, while with aromatase inhibitors + LNG-IUD, more than 60% may be free (p <0.01 with 24 cases in each branch) ”. Therefore, we estimated a total sample size of 48 patients (12 in each subgroup) to study in a period of 3 years, which was prolonged another 3 years due to difficulties for recruitment. However, we decided to finish it in March 2015 due to its low rate, to the need to make a final report in September-2015 and also because the patients undergoing TUGPA were not showing good clinical results. Nevertheless, their follow-up continued to the final data collection in July-2017. All data were entered into SPSS Statistics version 25.0 (IBM, Spain) to perform statistical analysis. Data are expressed as percentages, mean ± standard deviation (SD), median, minimum and maximum (min-max) values, and a 95% confidence interval (CI) (if applicable). The main dependent variables were the VAS score, the absence or presence of endometriomas in TVU, and the values of CA-125, as well as their evolution in later follow-ups. The main independent variables were Anastrozole+LNG-IUD or only LNG-IUD treatments, as well as CS or TUGPA of endometriomas. We applied descriptive statistical analysis for qualitative variables to determine frequencies and distribution using contingency tables and comparison of proportions. The chi-squared, Kruskal-Wallis, Mann-Whitney U and correlation tests were used to compare groups and parameters in the different follow-ups. For quantitative or numerical variables, we applied nonparametric tests for paired data to compare the values before and at 3, 6, and 9 months, and 1 and 2 years, and the last follow-up after treatment, calculating the Wilcoxon signed rank test, the signs test, the McNemar test (for dichotomous variants), and the marginal homogeneity test, noting in tables and graphs only the significant results. Likewise, nonparametric tests were applied to compare Anastrozole and non-Anastrozole groups. To determine the recurrence and reoperation rates, we calculated the percentage accumulated every 3 months up to 2 years, and then every year up to 6 years, pointing at the corresponding figures the patients at risk in each period, subtracting recurrences and loss to follow-up. All p values reported are 2-tailed, and p<0.05 was considered significant. Results Participants recruited and included in the study . The eligibility criteria were analyzed in 52 patients (see Fig. 1 ). After excluding 21 patients, 31 women were included in the CT and randomized in the 4 subgroups mentioned above. All patients had a LNG-IUD (Mirena®) for 6 months, and 15 of them also received Anastrozole for the same period. The latter were followed for 4.67 ± 1.63 years (95%CI: 3.76-5.57), and the first ones for 3.78 ± 1.77 years (95%CI: 2.84-4.72), without significant differences. Baseline characteristics . Table 1 shows the characteristics, antecedents, symptoms, laboratory tests, and ultrasound and operative findings of the four subgroups of patients. No significant differences were observed . Primary outcomes . The evolution of the primary efficacy variables, up to 2 years, in the four studied groups is showed in Table 2 . In the Anastrozole groups, especially in +CS, the VAS values (mainly dysmenorrhea) were significantly reduced and kept low. Similar results were observed in the levels of tumor markers and the recurrence of endometriomas, but differences were not significant if +TUGPA was performed. The reduction of VAS (dysmenorrhea and dyspareunia), CA-125, and endometriomas was equally significant in patients treated with LNG-IUD + CS without Anastrozole. CA-125 level also decreased significantly in the LNG-IUD + TUGPA –No Anastrozole group. A more detailed assessment of this evolution is represented in Fig. 2 (and in Fig. 3), according to the patients who took or not Anastrozole (in follow-up results, the re-operated cases were excluded). Fig. 2 represents the evolution of the symptoms scaled over 10 (absolute value of the VAS), as well as the evolution of dysmenorrhea, dyspareunia, and CPP scaled over 3. The most significant improvements were for dysmenorrhea and CPP during the taking of Anastrozole. Fig. 3 a shows that the percentage of reduction or improvement of the VAS score is more significant at 3 and 6 months, with or without Anastrozole, maintaining similar values during the follow-up period. On average, there was a significant improvement of symptoms during (difference 44%, 95%CI: 27.7-60.4) and after treatment at 6 months (43%, 95%CI: 29.9-56.2), which is maintained at follow-ups of 1 year (31%, 95%CI: 17.6-44.4) and 2 years (43.7%, 95%CI: 27.7-59.6). This improvement was more significant in those patients who had taken Anastrozole (at 3 months: 57%, 95%CI: 40.3-73.4; at 6 months: 51%, 95%CI: 33.3-68.7; at 1 year: 44.5%, 95%CI: 28-61; and at 2 years: 51.3%, 95%CI: 31.6-71). There are, however, no significant differences between Anastrozole and non-Anastrozole, except for at the 1-year follow-up (Mann-Whitney U test, p = 0.048). Regarding levels of CA-125 (Fig. 3b), we observed a significant reduction, similar to that of the VAS score, but only in those patients who did not take Anastrozole, in both the absolute values and the percentage of cases with high level of this marker (>35 U/mL), at least up to 1 year. In these patients, the decrease of CA-125 values was 64% (95%CI: 40.8-87.3) at 3 months and 73.8% (95%CI: 64.2-83.4) at 6 months versus 49.6% (95%CI: 19.6-79.7) and 53.8% (95%CI: 25.7-81.6), respectively, in patients treated with Anastrozole + Mirena®. The sonographic findings showed a similar behaviour (Fig. 3cd), with an increase of recurrent endometriomas until 9 months to 1 year that decreased when some patients were re-operated, but no significant differences were observed between Anastrozole and non-Anastrozole. Secondary outcomes . Fig. 4 shows the recurrence and reoperation rates observed during a 6-year follow-up period. Although the recurrence rate was similar at 2 years with or without Anastrozole (50%), the use of this AI delayed their appearance; however, differences were not statistically significant. In groups 1 and 3, both with Mirena® + CS, there were few recurrences, with simple cysts or small endometriomas. However, in patients treated with Mirena® + TUGPA (groups 2 and 4), the endometriomas increased (together with reoperations) when the LNG-IUD was removed (see table 2). Lines of the cumulative percentage of reoperations were also similar with or without Anastrozole. Fertility and clinical status of patients in the last control are shown in Table 3 . Ten percent of them got pregnant and a 13% remained infertile. At 4.2 ± 1.7 years of follow-up (95%CI: 3.57-4.85; median 4 years, range 1-7 years), 25% of cases were reoperated, 13% showed persistent endometriosis (although these women evolved well taking pill or other medications –oral naproxen-), and 61.3% were asymptomatic without taking any medication. The more interesting finding is that 88% of the patients in which CS was performed, with or without Anastrozole, were asymptomatic after 3 to 5 years without medication or reoperation, compared with only 21% if TUGPA was performed, with or without Anastrozole. Differences were significant between groups 1 and 2 (p = 0.004) and between groups 3 and 4 (p = 0.027), being equally significant (p = 0.019) in the four groups. Post-hoc or sensitivity analyses . No pathology related to the treatments was observed throughout the CT follow-up period. Discussion Our study shows that oral administration of 1 mg/day Anastrozole for 6 months, beginning before CS intervention of endometriosis, reduces or improves significantly the symptoms associated with the disease (especially dysmenorrhea and CPP) during and after treatment. No other significant advantages over the single insertion of LNG-IUD (Mirena®), prior to CS, were observed. The recurrence and reoperation rates were similar at 2 years with or without Anastrozole that were adversely influenced by the performance of TUGPA. These findings clarify what was previously reported about the use of Anastrozole in the treatment of endometriosis, suggesting that the clinical benefits reported after 6 months (pain relief, see Table S1) are partly due to the associated medications and that there are no other additional benefits about the endometriosis itself and its clinical evolution [3,4,12-15]. Strengths and weaknesses of the study . The main strength of the study would be the strict randomization of cases of young women with endometriomas and elevated CA-125, for both patients taking or not Anastrozole and inclusion in CS or TUGPA during the medical treatment. However, a limitation of this research is the low number of cases included in the CT because of the low recruitment rate and the poor preliminary results observed in the interim in patients treated with TUGPA. We trusted that these patients would evolve as well as those who were treated with CS, because of the additional use of Anastrozole and Mirena®, but it was not the case. However, the statistical tests are significant and, therefore, this is a valid CT that shows the poor results obtained performing TUGPA in endometriosis and which do not improve with the previous insertion of LNG-IUD (Mirena®) and/or oral Anastrozole for 6 months. A possible bias in this study could be the use of vitamin D (VD) in women taking Anastrozole, although the data on VD and endometriosis are controversial [16,17]. Discussion of the findings in relation to other studies . Initial studies and CTs had described the AIs as promising therapeutic agents for treatment of endometriosis [2,4] since they could suppress the local estrogen produced by aromatase-positive implants and subsequent proliferative effect, as well as blocking the action on COX-2 and prostaglandin E2, the latter being responsible for inflammation [7,18]. However, in most of these studies the use of AIs (Anastrozole or Letrozole) was associated with OCP or GnRH analogues, so its beneficial effects could correspond to these other medications or their association, rather than to the AIs themselves. Other case reports, series and prospective CTs using mainly Letrozole associated with noretindrone acetate (NETA) or OCP, compared to the use of the OCP or NETA alone [14,15], have been published after 2008 (see Table S1 ). Results do not show significant clinical advantages, but more cost and side effects related to the administration of Letrozole. Anastrozole was used only in 3 patients [19] with improvement of CPP and minimal side effects. Systematic reviews [20,21] seem to conclude that AI may have a place in endometriosis treatment, but there is no clear evidence of improvement in endometriosis-associated infertility [22]; and the Committee Opinion No. 663 on Aromatase Inhibitors in gynecologic practice [23] pointed that AI are a promising therapeutic option that may be useful for the management of endometriosis-associated pain in a combined therapy with progestins. The pathogenesis of endometriosis remains controversial. A recent and extensive review on it [24] shows that the innate ability of endometrial stem cells to regenerate cyclically seems to play a key role in the development of endometriosis, but also the dysregulated hormonal pathways. A genetic dysregulation would cause aberrant placement of those stem cells, and then immune cells, adhesion molecules, extracellular matrix metalloproteinase, and pro-inflammatory cytokines activate / alter the peritoneal microenvironment, creating the conditions for differentiation, adhesion, proliferation and survival of ectopic endometrial cells [25]. But in addition, the intracellular production of estrogens in these cells probably can also favour the development of the disease. Aromatase P450 (enzyme that catalyzes the conversion of androgens into estrogens) has been found both in endometriotic tissue as in the eutopic endometrium of women with endometriosis [6,26], and in endometriosis, there is also a deficiency of 17β-hydroxysteroid dehydrogenase (17β-HSD2) (an enzyme that converts 17β-estradiol into estrone modulating exposure to the action of estrogens [27]. So that both the local production of estrogens and the loss of protective mechanisms determine a higher level of estradiol that characterizes both endometriosis and the eutopic endometrium of affected women [24]. Dislocated basal endometrial fragments in the peritoneal cavity can now induce chronic inflammation and tissue injury and repair (TIAR) mechanisms, which activate local estrogen production, proliferation, and infiltrative growth leading to endometriosis [28]. Later, the high concentration of estrogens and the overexpression of ERβ favor the survival and development of ER-positive ectopic tissue. Progesterone resistance is also a characteristic of endometriotic tissue compared to eutopic endometrium [29], and it is caused by the down-regulation of the progesterone receptor (PR ) in ectopic tissue [30,31]. Progesterone action is crucial to decreasing inflammation in the endometrium, and deviant progesterone signaling results in a proinflammatory phenotype which favours the establishment of ectopic endometrial implants. In any case, when we proposed this prospective study to assess the efficacy of Anastrozole in endometriosis, we decided to associate it with the intrauterine insertion of an IUD containing LNG (for contraception and for a continued release of progestin). Previously Vercellini et al. [32] had published a pilot study using LNG-IUD versus expectant management after CS for symptomatic endometriosis with significant reduction of dysmenorrhea and risk of recurrence. Subsequently, other studies [9,33-40] have also shown that LNG-IUD is an effective and well accepted treatment to reduce dyspareunia and dysmenorrhea and increase quality of life in women with suspected endometriosis. However, the long-term maintenance therapy using LNG-IUD after surgery was not effective for preventing endometrioma recurrence [38]. These evidences agree with our prospective CT that shows a greater improvement of the painful symptoms and a certain time delay in the occurrence of recurrence in patients taking Anastrozole (with Calcium + VD simultaneously), although there were no clear significant differences with the group of no Anastrozole or other positive efficacy data in the administration of Anastrozole associated with Mirena® (versus only Mirena®). The tumor marker levels were normalized more clearly in the patients who did not take Anastrozole and the rates of recurrence and reoperations were similar. The worst result in short and long term was the performance of TUGPA (instead of CS), independently of the use of Anastrozole and Mirena®. Therefore, despite the fact that sometimes medical therapy (either Anastrozole/Mirena®, or Dienogest [41]) is sufficient to reduce the symptoms and signs of endometriosis, in a large number of patients it is necessary surgical eradication of lesions. In cases with intestinal deep infiltrating endometriosis, some authors [42,43] propose its complete eradication with a nerve and vascular preserving approach to restore normal pelvic anatomy and its functions. Conclusions Anastrozole for 6 months, beginning before CS of endometriosis, improves significantly the painful symptoms of endometriosis but it has no other significant advantages over the single insertion of LNG-IUD (Mirena®) during that same time period. LNG-IUD (Mirena®) associated with CS reduces significantly dysmenorrhea and dyspareunia, normalizes more effectively the values of CA-125, and also seems to decrease the rate of recurrences and long-term reoperations. However, Anastrozole / Mirena® associated with TUGPA are not very effective, so we deduce that these medications without surgery do not cure or significantly improve endometriosis itself. Future research directions should be focused on the observation of subsequent fertility, as well as to the long-term recurrences in a greater number of cases operated with CS after previous insertion of Mirena®, which could be maintained for 6-12 months, and even indefinitely, if patients do not want to get pregnant. Abbreviations AI, aromatase inhibitors; CI, confidence interval; CPP, chronic pelvic pain; CS, conservative surgery; CT, clinical trial; GnRH, gonadotropin-releasing hormone; LNG, levonorgestrel; LNG-IUD, levonorgestrel-releasing intrauterine device; OCP, oral contraceptive pill; SD, standard deviation; TUGPA, transvaginal ultrasound-guided puncture-aspiration; TVU, transvaginal ultrasound; VAS, visual analogue scale; Declarations Statement: This study adheres to CONSORT guidelines and include a completed CONSORT checklist as an additional file. Ethics approval and consent to participate : All subjects gave their informed consent for inclusion before they participated in the study. The study was conducted in accordance with the Declaration of Helsinki. And the protocol was approved by the Ethics Committee of San Juan University Hospital (26/08/2008). It was registered in the Eudra CT System of the European Medicines Agency (London, 29-Sept-2008; Nº EudraCT: 2008-005744-17) (07/11/2008) and then authorized by the Spanish Agency for Medicines and Health Products (AEMPS) (10/11/2008). Consent to participate: Written informed consent was obtained from all individual participants included in the study. Consent for publication : Written consent for publication of data was obtained from all individual participants included in the study. Availability of data and material: available. Code availability: SPSS fichas-endom-ensayo-casos-anastrozol AROM-total31-dic18 Competing interest: We declare no competing interests. Not applicable. Funding: This study was funded by the ‘Fondo de Investigaciones Sanitarias’, FIS PI07/0417, and PI10/01815. Ministry of Health, Madrid, Spain. Role of the funding source: “The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit it for publication.” Authors' contributions: P. Acién was the principal investigator in the FIS project and clinical trial, designed the study, made the review, tables and figures, and wrote the manuscript. I.Velasco participated in the FIS project and clinical trial as well as in the revision of the cases with endometriosis and reviewed the manuscript. M.Acién participated in the FIS project and clinical trial as well as in the revision of the cases with endometriosis, helped with the bibliographic search and reviewed the manuscript. PA had full access to all of the data in the study and took responsibility for the integrity of the data and the accuracy of the data analysis. All authors have read and approved the manuscript. Authors Agreement : The authors verify that the submitted material has not been published and is not currently submitted for publication elsewhere. We agree (i) to the inclusion of our names as authors on the manuscript; (ii) to the order in which our names are shown on the title page of the manuscript; (iii) that all persons listed as authors fulfil the International Committee of Medical Journal Editors (ICMJE) criteria for authorship; and (iv) that no persons who fulfil the ICMJE criteria for authorship have been omitted from the author list. Acknowledgments: - To all the doctors who collaborated in the project FIS-PI10-01815 (in addition to the authors who signed the study): Quereda-Seguí FJ, Martínez-Beltrán M, Chelea I, Fernández-Gálvez F, Abad-Gran M, Mayol-Belda MJ, Rueda-Puente J, Gutiérrez-Terán M, Caparrós-Cayuela E and Campos-Ferrer A. And to those who are part of the Research Collaborative Group FISABIO/Sant Joan d'Alacant University Hospital (in addition to those cited): Gascón-Castillo J, Montesinos-Llorca L, Rodríguez-Celdrán JM, Ruiz-Maciá E and Santoyo-Albert T. - To collaborators in the Pharmacy Service of San Juan University Hospital: Aznar MT and Camacho MD. - To Professor F. R. Reinoso for his advice and revision of the manuscript. - To statistical advisor: Quesada-Rico JA. References Acién P, Velasco I, Acién M, Quereda F. Treatment of endometriosis with transvaginal ultrasound-guided drainage and recombinant interleukin-2 left in the cysts: a third clinical trial. Gynecol Obstet Invest. 2010;69:203-211. https://doi.org/10.1159/000270901 Bulun SE, Zeitoun KM, Takayama K, Sasano H. Molecular basis for treating endometriosis with aromatase inhibitors. Hum Reprod Update. 2000;6:413-18. https://doi.org/10.1093/humupd/6.5.413 Soysal S, Soysal ME, Ozer S, Gul N, Gezgin T. 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LNGIUD + TUGPA (n = 7) Age (y) 30.7 ± 7.3 (21–40) 31.0 ± 5.6 (24–40) 33.6 ± 4.0 (26–40) 30.4 ± 8.2 (20–40) Parity ≥ 1 3 (37.5%) 1 (14.3%) 5 (55.5%) 0 - Infertility 0 - 1 (14.3%) 1 (11.1%) 1 (14.3%) Antecedents : a.Endometriosis, MST 1 (12.5%) 1 (14.3%) 2 (22.2%) 2 (28.6%) b.Endometriosis + myomas 1 (12.5%) 1 (14.3%) 0 - 0 - c.Endometriosis-OCP 0 - 1 (14.3%) 0 - 2 (28.6%) Symptoms : VAS/10 5.6 ± 1.6 (3–8) 6.1 ± 2.0 (4–9) 5.6 ± 2.2 (3–9) 4.7 ± 2.1 (3–8) - Dysmenorrhea/3 2.1 ± 0.2 (2-2.5) 2.1 ± 0.6 (1.5-3) 1.7 ± 0.6 (0.5-2) 1.8 ± 0.9 (0.5–2.5) - Dyspareunia/3 (7) 1.1 ± 0.9 (0.5-3) 1.6 ± 1.1 (0–3) 1.4 ± 1.0 (0–3) (4) 0.9 ± 1.0 (0–2) - CPP/3 1.7 ± 0.9 (0-2.5) 1.4 ± 0.8 (0.5–2.5) 1.7 ± 1.0 (0–3) 1.8 ± 1.5 (0–3) Trasvaginal US/ovaries : a.endometriomas, RO 2 (25%) 0 - 4 (44.4%) 0 - b.endometriomas LO 2 (25%) 3 (42.8%) 2 (22.2%) 5 (71.4%) c.bilateral/kissing ovaries/rvs. 4 (50%) 4 (57.1%) 3 (33.3%) 2 (28.6%) Analysis : - CA-125 80.5 ± 57.8 (36–190) 90.4 ± 37.6 (37–150) 56.3 ± 12.9 (36-70.4) 87 ± 42 (53–168) - CA-19-9 44.9 ± 63.5 (9.5–198) (6)58.9 ± 71 (2-191) (8)38 ± 19.4 (11–66) (6)36.6 ± 37 (11–111) Diagnosis : a.endometrioma, RO 1 (12.5%) 0 - 3 (33.3%) 0 - b.endometrioma, LO 1 (12.5%) 3 (42.8%) 2 (22.2%) 4 (57.1%) c.pelvic endometriomas 6 (75%) 4 (57.1%) 3 (33.3%) 3 (42.8%) d.recurrent endomet/rvs 0 - 0 - 1 (11.1%) 0 - Surgery : a.TUGPA 0 - 7 (100) 0 - 7 (100) b.laparoscopy, CS 7 (87.5%) 0 - 6 (66.7%) 0 - c.laparotomy, CS 1 (12.5%) 0 - 3 (33.3%) 0 - Findings in CS : a.endometriomas 4 (50%) - 5 (55.5%) - b.Severe pelvic endomet + end-omas 3 (37.5%) - 4 (44.4%) - c.endometriomas + myoma 1 (12.5%) - 0 - - Histopathology : a.cytology compatible with endometriosis - 7 (100) - 7 (100) b.endometriosis (cystic) 8 (100) (1 + Myo) 0 - 7 (77.7%) 0 - c.atypical endometriosis 0 - 0 - 2 (22.2%) 0 - Data are n(%), mean ± standard desviation (SD) and (min-max) values. TUGPA, transvaginal ultrasound-guided puncture-aspiration; CS, conservative surgery; MST, previous medical and surgical treatment; OCP, oral contraceptive pill; VAS, visual analogic scale; CPP, chronic pelvic pain; RO, right ovary; LO, left ovary; endomet, endometriosis; rvs, recto-vaginal septum. Table 2 Evolution of the primary efficacy variables in the 4 randomized groups of the Clinical Trial Group Variable Before Treatment (N), m ± SD or n(%) 3 months (DT) (N), m ± SD or n(%) 6 months (DT) (N), m ± SD or n(%) 9 months (3 m AT) (N), m ± SD or n(%) 1 year (6 m AT) (N), m ± SD or n(%) 2 years (1,5y AT) (N), m ± SD or n(%) (1) Anastrozol + LNG-IUD + CS : VAS/10 (8) 5.6 ± 1.6 (8) 2.4 ± 1.2 a1b2d2 (8) 2.4 ± 2.1 a1d1 (8) 2.3 ± 1.3 a1b2d2 (8) 2.6 ± 1.6 a1b2d1 (8) 2.4 ± 1.6 a1d1 -dysmenorrhea 2.1 ± 0.2 1.1 ± 0.7 a1b1d1 0.6 ± 0.8 a1b1d2 1 ± 0.5 a2b2d2 1.2 ± 0.9 a1b1d1 1.1 ± 0.7 a1b1d1 -dyspareunia (7) 1.1 ± 0.9 (7) 0.4 ± 0.5 (7) 0.6 ± 1.1 (7) 0.4 ± 0.6 a1b1d1 (7) 0.9 ± 1.8 (7) 0.4 ± 0.7 -CPP 1.8 ± 0.9 0.6 ± 0.5 a1b1d1 0.6 ± 0.4 a1b1d1 0.7 ± 0.5 a1b1d1 0.8 ± 0.5 a1b1d1 1.2 ± 1.6 TV ultras/ovaries : -normal or dysfunctional - 7(87.5) 5(62.5) 6(75) 7(87.5) 5(62.5) -simple cyst or small endomet - 1(12.5) 3(37.5) 2(25) 1(12.5) 2(25) -endometriomas (rvs) 8(100) 0- a2b2d2 0- a2b2d2 0- a2b2d2 0- a2b2d2 1(12.5) a1b1d1 Tumor markers : -CA-125 (8) 80.5 ± 57.8 (7) 19.5 ± 10.9 a1d1 (8)11.3 ± 3.6 a1b2d1 (7) 24.2 ± 26.2 (7)19.7 ± 10.5 a1b1d1 (8)19.5 ± 10.5 a1b2d1 -CA-19-9 (8) 44.9 ± 63.5 (7) 10.9 ± 8.6 a1 (6) 6 ± 3.1 a1b1 (6) 17.2 ± 22.1 a1 (6) 12.7 ± 13.8 b1 (7) 18.7 ± 26.8 (2) Anastrozole + LNG-IUD + TUGPA : VAS/10 : (7) 6.1 ± 2 (7) 3.1 ± 3.1 a1d1 (7) 3.6 ± 2.1 a1b1d1 (7) 4.9 ± 2.5 a1d1 (5) 3.6 ± 1.1 (4) 3.1 ± 1 -dysmenorrhea 2.1 ± 0.6 0.5 ± 0.9 a1b1d1 0.6 ± 0.6 a1b1d1 1.4 ± 0.4 a1d1 1.5 ± 0.8 1.4 ± 1 -dyspareunia 1.6 ± 1.1 0.9 ± 1 1.1 ± 1.1 1 ± 1 0.5 ± 0.4 0.4 ± 0.2 -CPP 1.4 ± 0.8 0.8 ± 0.9 1.4 ± 1.1 1.5 ± 1 1.1 ± 0.7 0.8 ± 0.5 TV ultras/ovaries : 2 op (28.6) 3 op (42.9) -normal or dysfunctional - 1(14.3) 0- 0- 0- 0- -simple cyst or small endomet - 3(42.9) 1(14.3) 1(14.3) 0- 3 (75)(42.9) -endometriomas (rvs) 7(100) 3(42.9) 6(85.7) 6(85.7) 5(100)(71.4) 1(25)(14.3) Tumor markers : -CA-125 (7) 90.4 ± 37.6 (7) 69.8 ± 105.7 (7) 74 ± 70.9 (6) 63.9 ± 31.1 (5) 71.1 ± 71.6 (4) 50.6 ± 36.1 -CA-19-9 (6) 58.9 ± 71 (7) 21.3 ± 16.5 (6) 64.9 ± 100.8 (5) 29.8 ± 22.2 (4) 46 ± 56.3 (4) 17.5 ± 11.8 (3) LNG-IUD, No Anastrozol + CS : VAS/10 : (9) 5.6 ± 2.2 (9) 2.9 ± 2 a1d1 (9) 3.1 ± 1.8 a1d1 (9) 3.5 ± 1.9 a1b1d1 (8) 4 ± 2 a1b1d1 (6) 2.8 ± 1.1 -dysmenorrhea 1.7 ± 0.6 0.8 ± 0.7 a1b1d1 0.8 ± 0.7 a1b2d1 1.4 ± 0.9 1.5 ± 1 (5) 1.3 ± 1 -dyspareunia 1.4 ± 1 (8) 0.8 ± 1 (8) 0.7 ± 0.5 a1b1d1 (8) 0.7 ± 0.7 a1b1d1 (7) 0.9 ± 0.7 a1d1 (5) 0.4 ± 0.5 -CPP 1.7 ± 1 0.8 ± 0.9 1 ± 0.7 0.8 ± 0.8 1 ± 1 (5) 0.4 ± 0.5 TV ultras/ovaries : -normal or dysfunctional - 8(88.9) 8(88.9) 5(55.6) 5(62.5) 3(50) -simple cyst or small endomet - 0- 1(11.1) 1(11.1) 2(25) 2(33.3) -endometriomas (rvs) 9(100) 1(11.1) 0- 2(22.2) 1(12.5) 1(16.7) Tumor markers : -CA-125 (9) 56.3 ± 12.9 (8) 11.4 ± 7.9 a1b2 (9)12.4 ± 8.9 a2b2d2 (9) 16 ± 9.1 a2b2d2 (8)16.7 ± 10.8 a1b2d2 (6) 21.2 ± 19 a1b1d1 -CA-19-9 (8) 38 ± 19.4 (6) 10.2 ± 4 a1 (8) 14.8 ± 11.3 a1d1 (8) 11.9 ± 6.5 a1b1d1 (7) 12.1 ± 6.8 a1b1d1 (6) 25.5 ± 22.2 (4) LNG-IUD, No Anastrozol + TUGPA : VAS/10 : (7) 4.6 ± 2.2 (7) 3.4 ± 1.8 (7) 3 ± 1.3 (7) 3.2 ± 1.5 (6) 3.6 ± 1.6 (2) 4.3 ± 2.5 -dysmenorrhea 1.6 ± 0.7 1.4 ± 0.9 1.1 ± 0.9 1.4 ± 0.6 1.3 ± 0.5 (1) 1 -dyspareunia (4) 0.9 ± 1 (6) 0.3 ± 0.4 (6) 0.3 ± 0.4 (5) 0.2 ± 0.4 (4) 0.5 ± 1 (1) 2 -CPP 1.6 ± 1.1 1.1 ± 0.9 1.1 ± 0.9 a1d1 0.9 ± 0.7 1.1 ± 0.9 (1) 2 TV ultras/ovaries : (1 op, 14,3%) (3 op, 42.9%) -normal or dysfunctional - 1(14.3) 0- 0- 1(16.7)(14.3) 1(50)(14.3) -simple cyst or small endomet - 2(28.6) 0- 0- 1(16.7)(14.3) 0- -endometriomas (rvs) 7(100) 4(57.1) 7(100) 7(100) 4(66.7)(57.1) 1(50)(14.3) Tumor markers : -CA-125 (7) 87 ± 42 (7)26.9 ± 18.1 a1b1d1 (7)26.6 ± 21.9 a1b1d1 (7)42.2 ± 37.8 a1b1d1 (6) 43.2 ± 24.2 a1d1 (2) 51.7 ± 3.4 -CA-19-9 (6) 36.6 ± 37.4 (5) 15.1 ± 14.3 (6) 12.3 ± 13 a1 (5) 21.2 ± 22.3 (5) 18.5 ± 13.2 (2) 18.9 ± 13.7 Data are n(%), mean ± standard desviation (SD). Nonparametric tests (for two related samples) between values before treatment and at 3 m, 6 m, 9 m, 1y and 2y.- Test of ranges with Wilcoxon signs: a1 = p < 0.05, a2 = p < 0.01 ; a3 = p < 0.001. Signs test: b1 = p < 0.05, b2 = p < 0.01, b3 = p < 0.001. Mc Nemar test (for dichotomous variants): c1 = p < 0.05, c2 = p < 0.01; c3 = p < 0.001. Marginal homogeneity test: d1 = p < 0.05, d2 = p < 0.01, d3 = p < 0.001. Only significant results are indicated. DT, during treatment; AT, after treatment; CS, conservative surgery; TUGPA, transvaginal ultrasound-guided puncture-aspiration; VAS, visual analogic scale; CPP, chronic pelvic pain; TV ultras, transvaginal ultrasound; endomet, endometrioma; rvs, rectovaginal septum; op, operated. Table 3 Fertility and clinical status in last control of the patients included in the clinical trial. Variable Gr. 1. A + LNGIUD + CS [n = 8] Gr. 2. A + LNGIUD+ TUGPA [n = 7] Gr. 3. LNGIUD + CS [n = 9] Gr. 4. LNGIUD+ TUGPA [n = 7] Total CT [N = 31] Years until last control 4.4 ± 1.8 5 ± 1,5 3,4 ± 1,3 4,2 ± 1,3 4,2 ± 1,7 Infertility 1 (12.5) 2 (28,6) 1 (11,1) 0- 4 (12,9) Pregnancies/deliveries 0- 1 (14,3) x 1 (11,1) 1 (14,3) 3 (9,7) Clinical status in last control: 1. Reoperated: -new CS 0 4 (57.1)* 0 3 (42.8) 7 (22.6) -Hyst + Adnexectomy 0- 0- 1 (11.1) 0- 1 (3.2) 2. Persist, well, taking OCP 1 (12.5) 2 (28.6) 0- 2 (28.6) 4 (12.9) 3. Well without medication 7 (87.5)* 1 (14.3) 8 (88.9)** 2 (28.6) 19 (61.3)*** Data are n(%) and mean ± SD. x ,1 case reoperation and then pregnancy. Statistical study.- H of Kruskal-Wallis: * between gr1 and gr2 p. 004, ** between gr3 and gr4 p. 027. - *** Chi-square Pearson among the 4 groups, p. 019. A, anastrozole; CT, clinical trial; CS, conservative surgery; Hyst, hysterectomy. Supplementary Files CONSORT2010ChecklistrevScRBMCWH.doc TableS1.publicationsrevIAromatasa.docx Table S1. Clinical publications on the use of Aromatase Inhibitors in women with endometriosis. CPP, chronic pelvic pain; VAS, visual analogue scale; OCP, oral contraceptive pill. Cite Share Download PDF Status: Published Journal Publication published 20 May, 2021 Read the published version in BMC Women's Health → Version 4 posted Review # 2 received at journal 09 Mar, 2021 Editorial decision: Major revision 09 Mar, 2021 Reviewer # 2 agreed at journal 05 Jan, 2021 Review # 1 received at journal 17 Dec, 2020 Reviewer # 1 agreed at journal 14 Dec, 2020 Reviewers invited by journal 13 Dec, 2020 Editor assigned by journal 09 Dec, 2020 Submission checks completed at journal 09 Dec, 2020 Editor invited by journal 09 Dec, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-51837","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":6303761,"identity":"5583491c-9842-476e-b22e-51af3cb481b2","order_by":0,"name":"Pedro Acién","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAm0lEQVRIiWNgGAWjYFACxgYGhgoGBgMStZwhTQtIVxspWvjbDzc+Lpx3ONqcgfnwB6K0SJxJbDaeue1w7s4GtjQJ4qy5wdgmzQvUsuEAjxlxOuRvMLb/5p0D0sL/mTiHGQBtYeZtANvCQJzDDIF+keY5lp674TCbGXFa5I4ff/iZp8Y6d8Px5sfEOQwBmElUPwpGwSgYBaMADwAABnkwDBT+55EAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0002-5773-1862","institution":"Emeritus Professor","correspondingAuthor":true,"prefix":"","firstName":"Pedro","middleName":"","lastName":"Acién","suffix":""},{"id":6303762,"identity":"25170c44-99b6-4e34-beef-ce0f42c71ec3","order_by":1,"name":"Irene Velasco","email":"","orcid":"","institution":"Hospital Universitari Sant Joan d'Alacant","correspondingAuthor":false,"prefix":"","firstName":"Irene","middleName":"","lastName":"Velasco","suffix":""},{"id":6303763,"identity":"7ffe30cd-72d5-4366-9b7d-bdb4896d3697","order_by":2,"name":"Maribel Acién","email":"","orcid":"","institution":"Hospital Universitari Sant Joan d'Alacant","correspondingAuthor":false,"prefix":"","firstName":"Maribel","middleName":"","lastName":"Acién","suffix":""}],"badges":[],"createdAt":"2020-07-31 11:58:34","currentVersionCode":4,"declarations":"","doi":"10.21203/rs.3.rs-51837/v4","doiUrl":"https://doi.org/10.21203/rs.3.rs-51837/v4","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12905-021-01347-9","type":"published","date":"2021-05-20T20:54:31+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":4538485,"identity":"51ffad53-5553-4dbe-998f-2529082844f6","added_by":"auto","created_at":"2020-12-28 11:02:06","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":129804,"visible":true,"origin":"","legend":"Trial profile","description":"","filename":"OnlineFig.1RS.png","url":"https://assets-eu.researchsquare.com/files/rs-51837/v4/312564afa4d8963ad515e488.png"},{"id":4538500,"identity":"4821ccc0-4971-4871-a013-e2972fd214b5","added_by":"auto","created_at":"2020-12-28 11:05:06","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":521029,"visible":true,"origin":"","legend":"Evolution of the symptoms score in patients taking or not Anastrozole: a, VAS. b, Dysmenorrhea. c, Dyspareunia. d, Chronic pelvic pain.","description":"","filename":"OnlineFig.2RS.png","url":"https://assets-eu.researchsquare.com/files/rs-51837/v4/6a70ef09a4fe09e83babd62c.png"},{"id":4538499,"identity":"4eb75204-4baf-4df0-88b1-c6624172ba58","added_by":"auto","created_at":"2020-12-28 11:05:06","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":687689,"visible":true,"origin":"","legend":"Evolution of the variables of primary efficacy taking or not Anastrozole: a, VAS, % improvement by treatment. b, % of cases with CA-125 \u003e35 UI/mL. c, Ultrasound finding (TVU) in the CT under Anastrozole (15 patients). d, Ultrasound finding (TVU) in the CT, no Anastrozole (16 patients). Normal or dysfunctional= findings of normal ovaries or with dysfunctional cyst (luteal).","description":"","filename":"OnlineFig.3RS.png","url":"https://assets-eu.researchsquare.com/files/rs-51837/v4/5c7d604075e3f7e4579725cc.png"},{"id":4538487,"identity":"94411beb-6bc3-4d72-801c-2efe5dedd1af","added_by":"auto","created_at":"2020-12-28 11:02:06","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":382112,"visible":true,"origin":"","legend":"Accumulated % of recurrences and reoperations for Anastrozole versus no Anastrozole.","description":"","filename":"OnlineFig.4RS.png","url":"https://assets-eu.researchsquare.com/files/rs-51837/v4/1c9c81ead31692f73c8d6c3e.png"},{"id":13639365,"identity":"04e06497-ae40-406d-b4bf-5272b555b2e0","added_by":"auto","created_at":"2021-09-17 08:55:32","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1438812,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-51837/v4/929a984e-cd25-45f8-ad22-ad9b582a908f.pdf"},{"id":4538410,"identity":"ae99f103-6dfb-4980-aec2-b1db1e76b31b","added_by":"auto","created_at":"2020-12-28 10:59:06","extension":"doc","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":223232,"visible":true,"origin":"","legend":"","description":"","filename":"CONSORT2010ChecklistrevScRBMCWH.doc","url":"https://assets-eu.researchsquare.com/files/rs-51837/v4/c9485bd0232862ecea2b1d87.doc"},{"id":4538414,"identity":"670384d1-5aaf-471d-947b-c05492b99f52","added_by":"auto","created_at":"2020-12-28 10:59:06","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":24958,"visible":true,"origin":"","legend":"Table S1. Clinical publications on the use of Aromatase Inhibitors in women with endometriosis. CPP, chronic pelvic pain; VAS, visual analogue scale; OCP, oral contraceptive pill.","description":"","filename":"TableS1.publicationsrevIAromatasa.docx","url":"https://assets-eu.researchsquare.com/files/rs-51837/v4/314d3109dc73f241e6cc116d.docx"}],"financialInterests":"","formattedTitle":"Anastrozole and Levonorgrestrel-Releasing Intrauterine Device in the Treatment of Endometriosis: A Randomized Clinical Trial.","fulltext":[{"header":"Highlights","content":"\u003col\u003e\n\u003cli\u003eAnastrozole and LNG-IUD for 6 months improve significantly the painful symptoms of endometriosis.\u003c/li\u003e\n\u003cli\u003eHowever, Anastrozole has no significant advantages over the single insertion of LNG-IUD (Mirena\u0026reg;).\u003c/li\u003e\n\u003cli\u003eAnastrozole and/or Mirena\u0026reg; associated with puncture-aspiration of endometriomas are not very effective.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Plain English Summary","content":"\u003cp\u003eThis was a randomized CT designed to study the effectiveness of an aromatase inhibitor (Anastrozole) associated to levonorgestrel-releasing intrauterine device (LNG-IUD, Mirena\u0026reg;) in the treatment of endometriosis. The eligibility criteria were presence of endometriomas \u0026gt;3\u0026times;4 cm (ultrasound), CA-125 values \u0026gt;35 U/mL and endometriosis symptoms assessed with a VAS\u0026gt;4; and these being the main outcome measures in addition to recurrences. The interventions were 1) administration of Anastrozole 1 mg/day and/or Mirena\u0026reg; for 6 months; and 2) to perform conservative surgery (CS, ovarian and fertility-sparing) or transvaginal ultrasound-guided puncture-aspiration (TUGPA) of endometriomas, one month after starting medical treatment.\u003c/p\u003e\n\u003cp\u003eThirty-one women were randomized to anastrozole+Mirena\u0026reg;+CS (n=8), anastrozole+Mirena\u0026reg;+TUGPA (n=7), Mirena\u0026reg;+CS (n=9), or Mirena\u0026reg;+TUGPA (n=7). The results showed a significant improvement in symptoms during the treatment which was maintained at 1 and 2 years and that was more significant in patients treated with anastrozole, although for CA-125, the most significant decrease was observed without anastrozole. After CS, a reduction of findings of endometriomas and long-term recurrences occurred, with or without anastrozole. At 4.2 \u0026plusmn; 1.7 years, 88% of the patients who underwent CS were asymptomatic, without medication or reoperation, compared to only 21% if TUGPA was performed, with or without anastrozole.\u003c/p\u003e\n\u003cp\u003eIn conclusion, dosing anastrozole for 6 months, starting one month before CS of endometriosis, reduces more significantly the painful symptoms and delays recurrences, but has no other significant advantages over the single insertion of LNG-IUD (Mirena\u0026reg;) during the same time. However, the medical treatments associated with TUGPA are not effective.\u003c/p\u003e"},{"header":"Background","content":"\u003cp\u003eThe therapeutic perspectives for endometriosis have been directed in the last years towards the use of a variety of new medications including immunomodulatory agents (i.e. local interleukin-2r [1]), selective estrogen and progesterone receptor modulators, GnRH antagonist, angiogenic inhibitors, or the third-generation aromatase inhibitors (AI) (i.e. Anastrozole and Letrozole), systemically and/or locally administered, and eventually without the need for surgery [2, 3-5]. Anastrozole inhibits aromatase and decreases the amount of estrogens in all tissues; thus, in positive aromatase endometriotic implants, it should prevent local estrogenic production and, therefore, endometriotic tissue proliferation [2, 6-8]. That estrogen suppression and subsequent response from the adenohypophysis could lead to an increase in gonadotropins with consequent ovarian stimulation and possible formation of dysfunctional cysts or eventual follicular rupture, ovulation, and pregnancy. Thus, in all studies in premenopausal women with endometriosis in which long-term AIs have been used, they have been associated with gonadotropin-releasing hormone (GnRH) analogues, to slow down gonadotropins and produce hypoestronism, or with progestins or oral contraceptive pills (OCP), which could also improve endometriosis and its symptoms. An alternative as a contraceptive method could be the use of a levonorgestrel-releasing intrauterine device (LNG-IUD), such as Mirena\u0026reg;, a device that contains 52 mg of levonorgestrel (LNG) and releases it in situ 20 \u0026mu;g/24 hours. LNG induces the atrophia of eutopic endometrium that would reduce or avoid the retrograde menstruation. Based on previous reports about the use of both medications (Anastrozole [3, 4] and Mirena\u0026Ograve; [9]) in endometriosis patients, our therapeutical proposal was to associate Anastrozole administered orally for 6 months with Mirena\u0026reg; during the same time period. Furthermore, although this medical treatment (Anastrozole and/or only Mirena) could be more effective when associated to the surgical exeresis of the endometriotic foci, we wanted to clarify whether this would also be the case when associated to transvaginal ultrasound-guided puncture-aspiration (TUGPA) of the endometriomas, as we had already done in previous works associating TUGPA with analogues or leaving r-IL2 in situ [1,10,11].\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eStudy objective\u003c/em\u003e: We proposed a clinical trial (CT), whose main objective was to assess the efficacy of AI Anastrozole associated with LNG-IUD (Mirena\u0026reg;) (compared with Mirena\u0026reg; alone), in the treatment of moderate and severe endometriosis and its symptoms, along with laparoscopic or laparotomic conservative surgery (CS) (ovarian and fertility-sparing), or with simple TUGPA of the endometriomas.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cem\u003eStudy design\u003c/em\u003e. Randomized, comparative and controlled clinical trial (CT) whose protocol (ENDOMET-IA-DIULNG08) was approved by the Ethics Committee of San Juan University Hospital (26-August-2008). It was registered in the Eudra CT System of the European Medicines Agency (London, 29-Sept-2008; N\u0026ordm; EudraCT: 2008-005744-17) (07/11/2008) and then authorized by the Spanish Agency for Medicines and Health Products (AEMPS) (10/11/2008).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eParticipants\u003c/em\u003e:\u0026nbsp; Premenopausal women with endometriomas recruited at the Endometriosis and Reproductive Medicine Consultation of San Juan University Hospital. They had been advised for CS, did not currently desire pregnancy, and accepted the insertion of LNG-IUD (Mirena\u0026reg;) for 6 months and randomization to perform conservative surgery (CS) with ovarian and fertility-sparing by laparoscopy or laparotomy, or only transvaginal ultrasound-guided puncture-aspiration (TUGPA) of endometriomas, 1 month after the IUD insertion.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eInclusion criteria\u003c/em\u003e: Young women (\u0026lt; 41 y) with significant clinical symptoms (score of visual analogue scale (VAS) \u0026ge; 4), elevated CA-125 (\u0026ge; 35 U/mL), and a transvaginal ultrasound (TVU) with suggestive findings of endometriomas (\u0026gt; 3\u0026times;4 cm). These patients could have a previous diagnosis and treatment (medical and/or surgical) of endometriosis, but they should not have received medical treatment in the last 3 months.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eExclusion criteria\u003c/em\u003e: i) Pregnancy; ii) Infertility with current desire for pregnancy; iii) No previous sexual intercourse and/or non-acceptance of insertion of Mirena\u0026reg;; iv) Acute or recurrent pelvic inflammatory disease or genital tract infection; v) Uterine malformations and/or leiomyomas; vi) Any medical pathology that could contraindicate the treatment with Anastrozole or LNG-IUD (Mirena\u0026reg;).\u003c/p\u003e\n\u003cp\u003eWritten informed consent was obtained from all patients before \u003cem\u003erandomization\u003c/em\u003e. Participants were randomized by computer, determined at the Hospital Pharmacy after a telephone call from the Endometriosis Consultation. Between January 15, 2009 (date of inclusion of the first patient) and March 15, 2015, the eligibility criteria were analyzed in 52 patients who had ovarian cystic tumors suggestive of endometriomas, with indication to CS. After excluding 21 patients due to not meeting all the inclusion criteria, doubts in the ultrasound diagnosis, or because they declined to participate, the other 31 women were included, randomized, treated and followed up according to the following subgroups: (1) Anastrozole-Mirena-CS (n = 8); (2) Anastrozole-Mirena-TUGPA (n = 7); (3) no Anastrozole-Mirena-CS (n = 9); and (4) no Anastrozole-Mirena-TUGPA (n = 7).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eProcedures\u003c/em\u003e. Medical treatments: (1) oral Anastrozole, 1 tablet of 1 mg daily for 6 months administered to patients in subgroups 1 and 2; (2) LNG-IUD (Mirena\u0026reg;) for all patients; (3) calcium carbonate and cholecalciferol (Ca + Vitamin D) to patients taking Anastrozole to avoid the damaging effects of AI on the bone. Surgical treatments: (1) laparoscopy (in 13 women, 76%) or laparotomy (in 4 women -in 2 was conversion-) with CS of endometriosis; or (2) TUGPA of endometriomas (in 14 women). All surgeries were performed or directed by the first author of the present study (PA).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eResearch plan\u003c/em\u003e: All patients will undergo a first analytical control, clinical exploration and TVU in the second half of the cycle, being randomized according to the subgroups previously exposed. Patients of subgroups 1 and 2 would start taking Anastrozole at the beginning of the next menstruation, placing the LNG-IUD (Mirena\u0026reg;) during it, as well as in the other subgroups. At the time, the surgical proposal to be practiced a month later was processed. Postoperative control follow-ups would be done at 3 and 6 months (time of withdrawal of Anastrozole and Mirena\u0026reg;); thereafter at 9, 12, 18, 24 months, and then annual follow-ups.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eAssessments\u003c/em\u003e. All patients must have a detailed medical history about their antecedents and previous treatments, also including clinical exploration, TVU, hormonal and tumor marker analysis (CA-125, CA-19-9) and symptoms score using our VAS [maximum 10 points, including dysmenorrhea (0-3), deep dyspareunia (0-3), chronic pelvic pain (CPP, 0-3), and others (0-1)]. In all subsequent follow-ups, TVU, analysis and VAS score for symptoms were repeated.\u003c/p\u003e\n\u003cp\u003eWe considered \u003cem\u003erecurrence\u003c/em\u003e of the disease when an endometrioma was detected in any control, which persisted or grew in subsequent follow-ups, associated with an increase in VAS score and/or CA-125 level. In any case, the recurrences of small endometriomas (1.5-3 cm) and endometriomas greater than 3\u0026times;4 cm are presented separately in the tables of results.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eOutcomes\u003c/em\u003e. \u003cem\u003ePrimary endpoint\u003c/em\u003e: clinical, analytical and ultrasound improvement assessed by (1) reduction or disappearance of symptoms; (2) normalization of CA-125 values; (3) reduction or disappearance of endometriomas. These parameters were studied in each postoperative control follow-up at 3 and 6 months; thereafter at 9, 12, 18, 24 months, and then in annual follow-ups. \u003cem\u003eSecondary endpoints\u003c/em\u003e: (1) decrease or disappearance of recurrences; (2) rate of reoperations; (3) subsequent pregnancy achievement; and (4) valuation of the clinical state in the last follow-up and the need for other treatments.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eSafety and adverse events\u003c/em\u003e. In laparoscopic or laparotomic surgery, peritoneal fluid and biopsies or surgical specimens were collected for cytological and histopathological studies. In TUGPA, endometrioma fluids were also collected for cytological analysis. Side effects and adverse events were registered and considered in each patient follow-up.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eStatistical analysis\u003c/em\u003e. Sample size: Based on previously published studies using AI [3,4,12,13] or LNG-IUD [9], in the research project-protocol of the clinical trial ENDOMET-IA-DIULNG08 (EudraCT No.: 2008-005744-17) we include the following analysis: \u0026ldquo;with respect to symptoms, with the LNG-IUD we expect to find improvements of 60% and, with associating aromatase inhibitors + LNG-IUD, of 94% (p \u0026lt;0.05 with 16 cases in each branch). Regarding recurrence of symptoms and endometriosis, after LNG-IUD it would be foreseeable that only 20-25% will be free of recurrence in two years, while with aromatase inhibitors + LNG-IUD, more than 60% may be free (p \u0026lt;0.01 with 24 cases in each branch) \u0026rdquo;. Therefore, we estimated a total sample size of 48 patients (12 in each subgroup) to study in a period of 3 years, which was prolonged another 3 years due to difficulties for recruitment. However, we decided to finish it in March 2015 due to its low rate, to the need to make a final report in September-2015 and also because the patients undergoing TUGPA were not showing good clinical results. Nevertheless, their follow-up continued to the final data collection in July-2017.\u003c/p\u003e\n\u003cp\u003eAll data were entered into SPSS Statistics version 25.0 (IBM, Spain) to perform statistical analysis. Data are expressed as percentages, mean \u0026plusmn; standard deviation (SD), median, minimum and maximum (min-max) values, and a 95% confidence interval (CI) (if applicable). The main dependent variables were the VAS score, the absence or presence of endometriomas in TVU, and the values of CA-125, as well as their evolution in later follow-ups. The main independent variables were Anastrozole+LNG-IUD or only LNG-IUD treatments, as well as CS or TUGPA of endometriomas. We applied descriptive statistical analysis for qualitative variables to determine frequencies and distribution using contingency tables and comparison of proportions. The chi-squared, Kruskal-Wallis, Mann-Whitney U and correlation tests were used to compare groups and parameters in the different follow-ups. For quantitative or numerical variables, we applied nonparametric tests for paired data to compare the values before and at 3, 6, and 9 months, and 1 and 2 years, and the last follow-up after treatment, calculating the\u0026nbsp;Wilcoxon signed\u0026nbsp;rank test, the signs test, the McNemar test (for dichotomous variants), and the marginal homogeneity test, noting in tables and graphs only the significant results. Likewise, nonparametric tests were applied to compare Anastrozole and non-Anastrozole groups. To determine the recurrence and reoperation rates, we calculated the percentage accumulated every 3 months up to 2 years, and then every year up to 6 years, pointing at the corresponding figures the patients at risk in each period, subtracting recurrences and loss to follow-up. All p values reported are 2-tailed, and p\u0026lt;0.05 was considered significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cem\u003eParticipants recruited and included in the study\u003c/em\u003e. The eligibility criteria were analyzed in 52 patients (see \u003cu\u003eFig. 1\u003c/u\u003e). After excluding 21 patients, 31 women were included in the CT and randomized in the 4 subgroups mentioned above. All patients had a LNG-IUD (Mirena\u0026reg;) for 6 months, and 15 of them also received Anastrozole for the same period. The latter were followed for 4.67 \u0026plusmn; 1.63 years (95%CI: 3.76-5.57), and the first ones for 3.78 \u0026plusmn; 1.77 years (95%CI: 2.84-4.72), without significant differences.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eBaseline characteristics\u003c/em\u003e. \u003cu\u003eTable 1\u003c/u\u003e shows the characteristics, antecedents, symptoms, laboratory tests, and ultrasound and operative findings of the four subgroups of patients. No significant differences were observed\u003cstrong\u003e.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003ePrimary outcomes\u003c/em\u003e. The evolution of the primary efficacy variables, up to 2 years, in the four studied groups is showed in \u003cu\u003eTable 2\u003c/u\u003e. In the Anastrozole groups, especially in +CS, the VAS values (mainly dysmenorrhea) were significantly reduced and kept low. Similar results were observed in the levels of tumor markers and the recurrence of endometriomas, but differences were not significant if +TUGPA was performed. The reduction of VAS (dysmenorrhea and dyspareunia), CA-125, and endometriomas was equally significant in patients treated with LNG-IUD + CS without Anastrozole. CA-125 level also decreased significantly in the LNG-IUD + TUGPA \u0026ndash;No Anastrozole group.\u003c/p\u003e\n\u003cp\u003eA more detailed assessment of this evolution is represented in \u003cu\u003eFig. 2\u003c/u\u003e (and in Fig. 3), according to the patients who took or not Anastrozole (in follow-up results, the re-operated cases were excluded). Fig. 2 represents the evolution of the symptoms scaled over 10 (absolute value of the VAS), as well as the evolution of dysmenorrhea, dyspareunia, and CPP scaled over 3. The most significant improvements were for dysmenorrhea and CPP during the taking of Anastrozole. \u003cu\u003eFig. 3\u003c/u\u003ea shows that the percentage of reduction or improvement of the VAS score is more significant at 3 and 6 months, with or without Anastrozole, maintaining similar values during the follow-up period. On average, there was a significant improvement of symptoms during (difference 44%, 95%CI: 27.7-60.4) and after treatment at 6 months (43%, 95%CI: 29.9-56.2), which is maintained at follow-ups of 1 year (31%, 95%CI: 17.6-44.4) and 2 years (43.7%, 95%CI: 27.7-59.6). This improvement was more significant in those patients who had taken Anastrozole (at 3 months: 57%, 95%CI: 40.3-73.4; at 6 months: 51%, 95%CI: 33.3-68.7; at 1 year: 44.5%, 95%CI: 28-61; and at 2 years: 51.3%, 95%CI: 31.6-71). There are, however, no significant differences between Anastrozole and non-Anastrozole, except for at the 1-year follow-up (Mann-Whitney U test, p = 0.048).\u003c/p\u003e\n\u003cp\u003eRegarding levels of CA-125 (Fig. 3b), we observed a significant reduction, similar to that of the VAS score, but only in those patients who did not take Anastrozole, in both the absolute values and the percentage of cases with high level of this marker (\u0026gt;35 U/mL), at least up to 1 year. In these patients, the decrease of CA-125 values was 64% (95%CI: 40.8-87.3) at 3 months and 73.8% (95%CI: 64.2-83.4) at 6 months versus 49.6% (95%CI: 19.6-79.7) and 53.8% (95%CI: 25.7-81.6), respectively, in patients treated with Anastrozole + Mirena\u0026reg;.\u003c/p\u003e\n\u003cp\u003eThe sonographic findings showed a similar behaviour (Fig. 3cd), with an increase of recurrent endometriomas until 9 months to 1 year that decreased when some patients were re-operated, but no significant differences were observed between Anastrozole and non-Anastrozole.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eSecondary outcomes\u003c/em\u003e. \u003cu\u003eFig. 4\u003c/u\u003e shows the recurrence and reoperation rates observed during a 6-year follow-up period. Although the recurrence rate was similar at 2 years with or without Anastrozole (50%), the use of this AI delayed their appearance; however, differences were not statistically significant. In groups 1 and 3, both with Mirena\u0026reg; + CS, there were few recurrences, with simple cysts or small endometriomas. However, in patients treated with Mirena\u0026reg; + TUGPA (groups 2 and 4), the endometriomas increased (together with reoperations) when the LNG-IUD was removed (see table 2). Lines of the cumulative percentage of reoperations were also similar with or without Anastrozole.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eFertility and clinical status\u003c/em\u003e of patients in the last control are shown in \u003cu\u003eTable 3\u003c/u\u003e. Ten percent of them got pregnant and a 13% remained infertile. At 4.2 \u0026plusmn; 1.7 years of follow-up (95%CI: 3.57-4.85; median 4 years, range 1-7 years), 25% of cases were reoperated, 13% showed persistent endometriosis (although these women evolved well taking pill or other medications \u0026ndash;oral naproxen-), and 61.3% were asymptomatic without taking any medication. The more interesting finding is that 88% of the patients in which CS was performed, with or without Anastrozole, were asymptomatic after 3 to 5 years without medication or reoperation, compared with only 21% if TUGPA was performed, with or without Anastrozole. Differences were significant between groups 1 and 2 (p = 0.004) and between groups 3 and 4 (p = 0.027), being equally significant (p = 0.019) in the four groups.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003ePost-hoc or sensitivity analyses\u003c/em\u003e. No pathology related to the treatments was observed throughout the CT follow-up period.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eOur study shows that oral administration of 1 mg/day Anastrozole for 6 months, beginning before CS intervention of endometriosis, reduces or improves significantly the symptoms associated with the disease (especially dysmenorrhea and CPP) during and after treatment. No other significant advantages over the single insertion of LNG-IUD (Mirena\u0026reg;), prior to CS, were observed. The recurrence and reoperation rates were similar at 2 years with or without Anastrozole that were adversely influenced by the performance of TUGPA. These findings clarify what was previously reported about the use of Anastrozole in the treatment of endometriosis, suggesting that the clinical benefits reported after 6 months (pain relief, see Table S1) are partly due to the associated medications and that there are no other additional benefits about the endometriosis itself and its clinical evolution [3,4,12-15].\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eStrengths and weaknesses of the study\u003c/em\u003e. The main strength of the study would be the strict randomization of cases of young women with endometriomas and elevated CA-125, for both patients taking or not Anastrozole and inclusion in CS or TUGPA during the medical treatment. However, a limitation of this research is the low number of cases included in the CT because of the low recruitment rate and the poor preliminary results observed in the interim in patients treated with TUGPA. We trusted that these patients would evolve as well as those who were treated with CS, because of the additional use of Anastrozole and Mirena\u0026reg;, but it was not the case. However, the statistical tests are significant and, therefore, this is a valid CT that shows the poor results obtained performing TUGPA in endometriosis and which do not improve with the previous insertion of LNG-IUD (Mirena\u0026reg;) and/or oral Anastrozole for 6 months. A possible bias in this study could be the use of vitamin D (VD) in women taking Anastrozole, although the data on VD and endometriosis are controversial [16,17].\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eDiscussion of the findings in relation to other studies\u003c/em\u003e. Initial studies and CTs had described the AIs as promising therapeutic agents for treatment of endometriosis [2,4] since they could suppress the local estrogen produced by aromatase-positive implants and subsequent proliferative effect, as well as blocking the action on COX-2 and prostaglandin E2, the latter being responsible for inflammation [7,18]. However, in most of these studies the use of AIs (Anastrozole or Letrozole) was associated with OCP or GnRH analogues, so its beneficial effects could correspond to these other medications or their association, rather than to the AIs themselves. Other case reports, series and prospective CTs using mainly Letrozole associated with noretindrone acetate (NETA) or OCP, compared to the use of the OCP or NETA alone [14,15], have been published after 2008 (see \u003cu\u003eTable S1\u003c/u\u003e). Results do not show significant clinical advantages, but more cost and side effects related to the administration of Letrozole. Anastrozole was used only in 3 patients [19] with improvement of CPP and minimal side effects. Systematic reviews [20,21]\u0026nbsp; seem to conclude that AI may have a place in endometriosis treatment, but there is no clear evidence of improvement in endometriosis-associated infertility [22]; and the Committee Opinion No. 663 on Aromatase Inhibitors in gynecologic practice [23] pointed that AI are a promising therapeutic option that may be useful for the management of endometriosis-associated pain in a combined therapy with progestins.\u003c/p\u003e\n\u003cp\u003eThe pathogenesis of endometriosis remains controversial. A recent and extensive review on it [24] shows that the innate ability of endometrial stem cells to regenerate cyclically seems to play a key role in the development of endometriosis, but also the dysregulated hormonal pathways. A genetic dysregulation would cause aberrant placement of those stem cells, and then immune cells, adhesion molecules, extracellular matrix metalloproteinase, and pro-inflammatory cytokines activate / alter the peritoneal microenvironment, creating the conditions for differentiation, adhesion, proliferation and survival of ectopic endometrial cells [25]. But in addition, the intracellular production of estrogens in these cells probably can also favour the development of the disease. Aromatase P450 (enzyme that catalyzes the conversion of androgens into estrogens) has been found both in endometriotic tissue as in the eutopic endometrium of women with endometriosis [6,26], and in endometriosis, there is also a deficiency of 17\u0026beta;-hydroxysteroid dehydrogenase (17\u0026beta;-HSD2) (an enzyme that converts 17\u0026beta;-estradiol into estrone modulating exposure to the action of estrogens [27]. So that both the local production of estrogens and the loss of protective mechanisms determine a higher level of estradiol that characterizes both endometriosis and the eutopic endometrium of affected women [24]. Dislocated basal endometrial fragments in the peritoneal cavity can now induce chronic inflammation and tissue injury and repair (TIAR) mechanisms, which activate local estrogen production, proliferation, and infiltrative growth leading to endometriosis [28]. Later, the high concentration of estrogens and the overexpression of ER\u0026beta; favor the survival and development of ER-positive ectopic tissue. Progesterone resistance is also a characteristic of endometriotic tissue compared to eutopic endometrium [29], and it is caused by the down-regulation of the progesterone receptor (PR ) in ectopic tissue [30,31]. Progesterone action is crucial to decreasing inflammation in the endometrium, and deviant progesterone signaling results in a proinflammatory phenotype which favours the establishment of ectopic endometrial implants.\u003c/p\u003e\n\u003cp\u003eIn any case, when we proposed this prospective study to assess the efficacy of Anastrozole in endometriosis, we decided to associate it with the intrauterine insertion of an IUD containing LNG (for contraception and for a continued release of progestin). Previously Vercellini et al. [32] had published a pilot study using LNG-IUD versus expectant management after CS for symptomatic endometriosis with significant reduction of dysmenorrhea and risk of recurrence. Subsequently, other studies [9,33-40] have also shown that LNG-IUD is an effective and well accepted treatment to reduce dyspareunia and dysmenorrhea and increase quality of life in women with suspected endometriosis. However, the long-term maintenance therapy using LNG-IUD after surgery was not effective for preventing endometrioma recurrence [38]. These evidences agree with our prospective CT that shows a greater improvement of the painful symptoms and a certain time delay in the occurrence of recurrence in patients taking Anastrozole (with Calcium + VD simultaneously), although there were no clear significant differences with the group of no Anastrozole or other positive efficacy data in the administration of Anastrozole associated with Mirena\u0026reg; (versus only Mirena\u0026reg;). The tumor marker levels were normalized more clearly in the patients who did not take Anastrozole and the rates of recurrence and reoperations were similar. The worst result in short and long term was the performance of TUGPA (instead of CS), independently of the use of Anastrozole and Mirena\u0026reg;.\u003c/p\u003e\n\u003cp\u003eTherefore, despite the fact that sometimes medical therapy (either Anastrozole/Mirena\u0026reg;, or Dienogest [41]) is sufficient to reduce the symptoms and signs of endometriosis, in a large number of patients it is necessary surgical eradication of lesions. In cases with intestinal deep infiltrating endometriosis, some authors [42,43] propose its complete eradication with a nerve and vascular preserving approach to restore normal pelvic anatomy and its functions.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eAnastrozole for 6 months, beginning before CS of endometriosis, improves significantly the painful symptoms of endometriosis but it has no other significant advantages over the single insertion of LNG-IUD (Mirena\u0026reg;) during that same time period. LNG-IUD (Mirena\u0026reg;) associated with CS reduces significantly dysmenorrhea and dyspareunia, normalizes more effectively the values of CA-125, and also seems to decrease the rate of recurrences and long-term reoperations. However, Anastrozole / Mirena\u0026reg; associated with TUGPA are not very effective, so we deduce that these medications without surgery do not cure or significantly improve endometriosis itself.\u003c/p\u003e\n\u003cp\u003eFuture research directions should be focused on the observation of subsequent fertility, as well as to the long-term recurrences in a greater number of cases operated with CS after previous insertion of Mirena\u0026reg;, which could be maintained for 6-12 months, and even indefinitely, if patients do not want to get pregnant.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eAI, aromatase inhibitors; CI, confidence interval; CPP, chronic pelvic pain; CS, conservative surgery; CT, clinical trial; GnRH, gonadotropin-releasing hormone; LNG, levonorgestrel; LNG-IUD, levonorgestrel-releasing intrauterine device; OCP, oral contraceptive pill; SD, standard deviation; TUGPA, transvaginal ultrasound-guided puncture-aspiration; TVU, transvaginal ultrasound; VAS, visual analogue scale;\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cem\u003eStatement: \u003c/em\u003eThis study adheres to CONSORT guidelines and include a completed CONSORT checklist as an additional file.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eEthics approval and consent to participate\u003c/em\u003e: All subjects gave their informed consent for inclusion before they participated in the study. The study was conducted in accordance with the Declaration of Helsinki. And the protocol was approved by the Ethics Committee of San Juan University Hospital (26/08/2008). It was registered in the Eudra CT System of the European Medicines Agency (London, 29-Sept-2008; N\u0026ordm; EudraCT: 2008-005744-17) (07/11/2008) and then authorized by the Spanish Agency for Medicines and Health Products (AEMPS) (10/11/2008).\u003c/p\u003e\n\u003cp\u003eConsent to participate:\u0026nbsp; Written informed consent was obtained from all individual participants included in the study.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eConsent for publication\u003c/em\u003e: Written consent for publication of data was obtained from all individual participants included in the study.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eAvailability of data and material:\u003c/em\u003e available. Code availability: SPSS fichas-endom-ensayo-casos-anastrozol AROM-total31-dic18\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eCompeting interest:\u003c/em\u003e We declare no competing interests. Not applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cem\u003eFunding: \u003c/em\u003eThis study was funded by the \u0026lsquo;Fondo de Investigaciones Sanitarias\u0026rsquo;, FIS PI07/0417, and PI10/01815. Ministry of Health, Madrid, Spain. Role of the funding source: \u0026ldquo;The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit it for publication.\u0026rdquo;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eAuthors' contributions:\u003c/em\u003e P. Aci\u0026eacute;n was the principal investigator in the FIS project and clinical trial, designed the study, made the review, tables and figures, and wrote the manuscript. I.Velasco participated in the FIS project and clinical trial as well as in the revision of the cases with endometriosis and reviewed the manuscript. M.Aci\u0026eacute;n participated in the FIS project and clinical trial as well as in the revision of the cases with endometriosis, helped with the bibliographic search and reviewed the manuscript. PA had full access to all of the data in the study and took responsibility for the integrity of the data and the accuracy of the data analysis. All authors have read and approved the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eAuthors Agreement\u003c/em\u003e: The authors verify that the submitted material has not been published and is not currently submitted for publication elsewhere. We agree (i) to the inclusion of our names as authors on the manuscript; (ii) to the order in which our names are shown on the title page of the manuscript; (iii) that all persons listed as authors fulfil the International Committee of Medical Journal Editors (ICMJE) criteria for authorship; and (iv) that no persons who fulfil the ICMJE criteria for authorship have been omitted from the author list.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eAcknowledgments:\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e- \u003c/strong\u003eTo all the doctors who collaborated in the project FIS-PI10-01815 (in addition to the authors who signed the study): Quereda-Segu\u0026iacute; FJ, Mart\u0026iacute;nez-Beltr\u0026aacute;n M, Chelea I, Fern\u0026aacute;ndez-G\u0026aacute;lvez F, Abad-Gran M, Mayol-Belda MJ, Rueda-Puente J, Guti\u0026eacute;rrez-Ter\u0026aacute;n M, Caparr\u0026oacute;s-Cayuela E and Campos-Ferrer A. And to those who are part of the Research Collaborative Group FISABIO/Sant Joan d'Alacant University Hospital (in addition to those cited): Gasc\u0026oacute;n-Castillo J, Montesinos-Llorca L, Rodr\u0026iacute;guez-Celdr\u0026aacute;n JM, Ruiz-Maci\u0026aacute; E and Santoyo-Albert T.\u003c/p\u003e\n\u003cp\u003e- To collaborators in the Pharmacy Service of San Juan University Hospital: Aznar MT and Camacho MD.\u003c/p\u003e\n\u003cp\u003e- To Professor F. R. Reinoso for his advice and revision of the manuscript.\u003c/p\u003e\n\u003cp\u003e- To statistical advisor: Quesada-Rico JA.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eAci\u0026eacute;n P, Velasco I, Aci\u0026eacute;n M, Quereda F. Treatment of endometriosis with transvaginal ultrasound-guided drainage and recombinant interleukin-2 left in the cysts: a third clinical trial. Gynecol Obstet Invest. 2010;69:203-211. https://doi.org/10.1159/000270901\u003c/li\u003e\n\u003cli\u003eBulun SE, Zeitoun KM, Takayama K, Sasano H. Molecular basis for treating endometriosis with aromatase inhibitors. Hum Reprod Update. 2000;6:413-18. https://doi.org/10.1093/humupd/6.5.413\u003c/li\u003e\n\u003cli\u003eSoysal S, Soysal ME, Ozer S, Gul N, Gezgin T. The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial. Hum Reprod. 2004;19:160-167. Doi: 10.1093/humrep/deh035.\u003c/li\u003e\n\u003cli\u003eAmsterdam LL, Gentry W, Jobanputra S, Wolf M, Rubin SD, Bulun SE. Anastrazole and oral contraceptives: a novel treatment for endometriosis. Fertil Steril. 2005;84:300-304. https://doi.org/10.1016/j.fertnstert.2005.02.018\u003c/li\u003e\n\u003cli\u003eHefler LA, Grimm C, van Trotsenburg M, Nagele F. 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Arch Gynecol Obstet. 2009;280:529\u0026ndash;538. \u003ca href=\"https://doi.org/10.1007/s00404-009-1191-0\"\u003ehttps://doi.org/10.1007/s00404-009-1191-0\u003c/a\u003e.\u003c/li\u003e\n\u003cli\u003ePatel BG, Rudnicki M, Yu J, Shu Y, Taylor RN. Progesterone resistance in endometriosis: Origins, consequences and interventions. Acta Obstet Gynecol Scand. 2017;96:623\u0026ndash;632. \u003ca href=\"https://doi.org/10.1111/aogs.13156\"\u003ehttps://doi.org/10.1111/aogs.13156\u003c/a\u003e.\u003c/li\u003e\n\u003cli\u003eMcKinnon B, Mueller M, Montgomery G. Progesterone Resistance in Endometriosis: An Acquired Property?. Trends Endocrinol Metab. 2018;29:535\u0026ndash;548. \u003ca href=\"https://doi.org/10.1016/j.tem.2018.05.006\"\u003ehttps://doi.org/10.1016/j.tem.2018.05.006\u003c/a\u003e.\u003c/li\u003e\n\u003cli\u003eBulun SE, Cheng Y-H, Yin P, Imir G, Utsunomiya H, Attar E, et al.\u0026nbsp; Progesterone resistance in endometriosis: Link to failure to metabolize estradiol. Mol Cell Endocrinol. 2006;248:94\u0026ndash;103. https://doi.org/10.1016/j.mce.2005.11.041.\u003c/li\u003e\n\u003cli\u003eVercellini P, Frontino G, De Giorgi O, Aimi G, Zaina B, Crosignani PG. Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study. Fertil Steril. 2003;80:305-09. https://doi.org/10.1016/S0015-0282(03)00608-3\u003c/li\u003e\n\u003cli\u003eGomes MKO, Ferriani RA, Rosa e Silva JC, Japur de S\u0026aacute; Rosa e Silva AC, Vieira CS, C\u0026acirc;ndido dos Reis FJ. The levonorgestrel-releasing intrauterine system and endometriosis staging. Fertil Steril. 2007;87:1231-34. https://doi.org/10.1016/j.fertnstert.2006.11.044\u003c/li\u003e\n\u003cli\u003eWong AY, Tang LC, Chin RK. 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Acta Obstet Gynecol Scand. 2014;93:38-44. https://doi.org/10.1111/aogs.12294|\u003c/li\u003e\n\u003cli\u003eKim ML, Cho YJ, Kim MK, Jung YW, Yun BS, Seong SJ. The efficacy of long-term maintenance therapy with a levonorgestrel-releasing intrauterine system for prevention of ovarian endometrioma recurrence. Int J Gynaecol Obstet. 2016;134:256-59. https://doi.org/10.1016/j.ijgo.2016.03.017\u003c/li\u003e\n\u003cli\u003eChen YJ, Hsu TF, Huang BS, Tsai HW, Chang YH, Wang PH. Postoperative maintenance levonorgestrel-releasing intrauterine system and endometrioma recurrence: a randomized controlled study. Am J Obstet Gynecol. 2017;216:582.e1-582.e9. https://doi.org/10.1016/j.ajog.2017.02.008\u003c/li\u003e\n\u003cli\u003eKim MK, Chon SJ, Lee JH, Yun BH, Cho SH, Choi YS, et al. Postoperative Levonorgestrel-Releasing Intrauterine System Insertion After Gonadotropin-Releasing Hormone Agonist Treatment for Preventing Endometriotic Cyst Recurrence: A Prospective Observational Study. Reprod Sci. 2018;25:39-43. \u003ca href=\"https://doi.org/10.1177/1933719117718274\"\u003ehttps://doi.org/10.1177/1933719117718274\u003c/a\u003e\u003c/li\u003e\n\u003cli\u003eYucel N, Baskent E, Karamustafaoglu Balci B, Goynumer G. The levonorgestrel-releasing intrauterine system is associated with a reduction in dysmenorrhea and dyspareunia, a decrease in CA 125 levels, and an increase in quality of life in women with suspected endometriosis. Aust N Z J Obstet Gynaecol. 2018;58:560-63. doi: 10.1111/ajo.12773.\u003c/li\u003e\n\u003cli\u003eLagan\u0026agrave; AS, Vitale SG, Granese R, Palmara V, Ban Frangež H, Vrtačnik-Bokal E, et al. Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside. Expert Opin Drug Metab Toxicol. 2017;13(6):593-596. doi: 10.1080/17425255.2017.1297421.\u003c/li\u003e\n\u003cli\u003eLagan\u0026agrave; AS, Vitale SG, Trovato MA, Palmara VI, Chiara Rapisarda AM, Granese R, et al. Full-Thickness Excision versus Shaving by Laparoscopy for Intestinal Deep Infiltrating Endometriosis: Rationale and Potential Treatment Options. Biomed Res Int. 2016;2016:3617179. doi: 10.1155/2016/3617179.\u003c/li\u003e\n\u003cli\u003eRaffaelli R, Garzon S, Baggio S, Genna M, Pomini P, Lagan\u0026agrave; AS, et al. Mesenteric vascular and nerve sparing surgery in laparoscopic segmental intestinal resection for deep infiltrating endometriosis. Eur J Obstet Gynecol Reprod Biol. 2018;231:214-219. doi: 10.1016/j.ejogrb.2018.10.057.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cdiv class=\"gridtable\" style='box-sizing: inherit; color: rgb(74, 74, 74); font-family: Roboto, BlinkMacSystemFont, -apple-system, \"Segoe UI\", Oxygen, Ubuntu, Cantarell, \"Fira Sans\", \"Droid Sans\", \"Helvetica Neue\", Helvetica, Arial, sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;'\u003e\n \u003ctable border=\"1\" style=\"box-sizing: inherit; border-collapse: collapse; border-spacing: 0px;\"\u003e\n \u003ccaption style=\"box-sizing: inherit;\"\u003e\n \u003cdiv class=\"CaptionNumber\" style=\"box-sizing: inherit;\"\u003eTable 1\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\" style=\"box-sizing: inherit;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eBaseline characteristics of the patients included in the Clinical Trial.\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead style=\"box-sizing: inherit;\"\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eCharacteristics\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eG1. Anastrozol\u0026thinsp;+\u0026thinsp;LNGIUD\u0026thinsp;+\u0026thinsp;CS (n\u0026thinsp;=\u0026thinsp;8)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eG2. 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LNGIUD\u0026thinsp;+\u0026thinsp;TUGPA (n\u0026thinsp;=\u0026thinsp;7)\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody style=\"box-sizing: inherit;\"\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eAge (y)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e30.7\u0026thinsp;\u0026plusmn;\u0026thinsp;7.3 (21\u0026ndash;40)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e31.0\u0026thinsp;\u0026plusmn;\u0026thinsp;5.6 (24\u0026ndash;40)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e33.6\u0026thinsp;\u0026plusmn;\u0026thinsp;4.0 (26\u0026ndash;40)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e30.4\u0026thinsp;\u0026plusmn;\u0026thinsp;8.2 (20\u0026ndash;40)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eParity\u0026thinsp;\u0026ge;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (37.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (14.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5 (55.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eInfertility\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (14.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (11.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (14.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eAntecedents\u003c/em\u003e:\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ea.Endometriosis, MST\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (12.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (14.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (22.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (28.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eb.Endometriosis\u0026thinsp;+\u0026thinsp;myomas\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (12.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (14.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ec.Endometriosis-OCP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (14.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (28.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eSymptoms\u003c/em\u003e: VAS/10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5.6\u0026thinsp;\u0026plusmn;\u0026thinsp;1.6 (3\u0026ndash;8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e6.1\u0026thinsp;\u0026plusmn;\u0026thinsp;2.0 (4\u0026ndash;9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5.6\u0026thinsp;\u0026plusmn;\u0026thinsp;2.2 (3\u0026ndash;9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4.7\u0026thinsp;\u0026plusmn;\u0026thinsp;2.1 (3\u0026ndash;8)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e- Dysmenorrhea/3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.2 (2-2.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.6 (1.5-3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.7\u0026thinsp;\u0026plusmn;\u0026thinsp;0.6 (0.5-2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.8\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9 (0.5\u0026ndash;2.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e- Dyspareunia/3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 1.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9 (0.5-3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.6\u0026thinsp;\u0026plusmn;\u0026thinsp;1.1 (0\u0026ndash;3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.4\u0026thinsp;\u0026plusmn;\u0026thinsp;1.0 (0\u0026ndash;3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(4) 0.9\u0026thinsp;\u0026plusmn;\u0026thinsp;1.0 (0\u0026ndash;2)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e- CPP/3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.7\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9 (0-2.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.8 (0.5\u0026ndash;2.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.7\u0026thinsp;\u0026plusmn;\u0026thinsp;1.0 (0\u0026ndash;3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.8\u0026thinsp;\u0026plusmn;\u0026thinsp;1.5 (0\u0026ndash;3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eTrasvaginal US/ovaries\u003c/em\u003e:\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ea.endometriomas, RO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (25%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4 (44.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eb.endometriomas LO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (25%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (42.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (22.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5 (71.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ec.bilateral/kissing ovaries/rvs.\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4 (50%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4 (57.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (33.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (28.6%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eAnalysis\u003c/em\u003e:\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e- CA-125\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e80.5\u0026thinsp;\u0026plusmn;\u0026thinsp;57.8 (36\u0026ndash;190)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e90.4\u0026thinsp;\u0026plusmn;\u0026thinsp;37.6 (37\u0026ndash;150)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e56.3\u0026thinsp;\u0026plusmn;\u0026thinsp;12.9 (36-70.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e87\u0026thinsp;\u0026plusmn;\u0026thinsp;42 (53\u0026ndash;168)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e- CA-19-9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e44.9\u0026thinsp;\u0026plusmn;\u0026thinsp;63.5 (9.5\u0026ndash;198)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6)58.9\u0026thinsp;\u0026plusmn;\u0026thinsp;71 (2-191)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8)38\u0026thinsp;\u0026plusmn;\u0026thinsp;19.4 (11\u0026ndash;66)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6)36.6\u0026thinsp;\u0026plusmn;\u0026thinsp;37 (11\u0026ndash;111)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eDiagnosis\u003c/em\u003e:\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ea.endometrioma, RO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (12.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (33.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eb.endometrioma, LO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (12.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (42.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (22.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4 (57.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ec.pelvic endometriomas\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e6 (75%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4 (57.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (33.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (42.8%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ed.recurrent endomet/rvs\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (11.1%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eSurgery\u003c/em\u003e:\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ea.TUGPA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7 (100)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7 (100)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eb.laparoscopy, CS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7 (87.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e6 (66.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ec.laparotomy, CS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (12.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (33.3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eFindings in CS\u003c/em\u003e:\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ea.endometriomas\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4 (50%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5 (55.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eb.Severe pelvic endomet\u0026thinsp;+\u0026thinsp;end-omas\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (37.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4 (44.4%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ec.endometriomas\u0026thinsp;+\u0026thinsp;myoma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (12.5%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eHistopathology\u003c/em\u003e:\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ea.cytology compatible with endometriosis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7 (100)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7 (100)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eb.endometriosis (cystic)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e8 (100) (1\u0026thinsp;+\u0026thinsp;Myo)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7 (77.7%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ec.atypical endometriosis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (22.2%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0 -\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003ctfoot style=\"box-sizing: inherit;\"\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd colspan=\"5\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; text-align: left;\"\u003eData are n(%), mean\u0026thinsp;\u0026plusmn;\u0026thinsp;standard desviation (SD) and (min-max) values. TUGPA, transvaginal ultrasound-guided puncture-aspiration; CS, conservative surgery; MST, previous medical and surgical treatment; OCP, oral contraceptive pill; VAS, visual analogic scale; CPP, chronic pelvic pain; RO, right ovary; LO, left ovary; endomet, endometriosis; rvs, recto-vaginal septum.\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tfoot\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53); font-family: Roboto, BlinkMacSystemFont, -apple-system, \"Segoe UI\", Oxygen, Ubuntu, Cantarell, \"Fira Sans\", \"Droid Sans\", \"Helvetica Neue\", Helvetica, Arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;'\u003e\u0026nbsp;\u003c/p\u003e\n\u003cdiv class=\"gridtable\" style='box-sizing: inherit; color: rgb(74, 74, 74); font-family: Roboto, BlinkMacSystemFont, -apple-system, \"Segoe UI\", Oxygen, Ubuntu, Cantarell, \"Fira Sans\", \"Droid Sans\", \"Helvetica Neue\", Helvetica, Arial, sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;'\u003e\n \u003ctable border=\"1\" style=\"box-sizing: inherit; border-collapse: collapse; border-spacing: 0px;\"\u003e\n \u003ccaption style=\"box-sizing: inherit;\"\u003e\n \u003cdiv class=\"CaptionNumber\" style=\"box-sizing: inherit;\"\u003eTable 2\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\" style=\"box-sizing: inherit;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eEvolution of the primary efficacy variables in the 4 randomized groups of the Clinical Trial\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead style=\"box-sizing: inherit;\"\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eGroup\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eVariable\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eBefore Treatment\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(N), m\u0026thinsp;\u0026plusmn;\u0026thinsp;SD or n(%)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 months\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(DT)\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(N), m\u0026thinsp;\u0026plusmn;\u0026thinsp;SD or n(%)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e6 months\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(DT)\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(N), m\u0026thinsp;\u0026plusmn;\u0026thinsp;SD or n(%)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e9 months\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(3\u0026nbsp;m AT)\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(N), m\u0026thinsp;\u0026plusmn;\u0026thinsp;SD or n(%)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1\u0026nbsp;year\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6\u0026nbsp;m AT)\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(N), m\u0026thinsp;\u0026plusmn;\u0026thinsp;SD or n(%)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2\u0026nbsp;years\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(1,5y AT)\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(N), m\u0026thinsp;\u0026plusmn;\u0026thinsp;SD or n(%)\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody style=\"box-sizing: inherit;\"\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cstrong style=\"box-sizing: inherit; color: rgb(54, 54, 54); font-weight: 700;\"\u003e(1) Anastrozol\u0026thinsp;+\u0026thinsp;LNG-IUD\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cstrong style=\"box-sizing: inherit; color: rgb(54, 54, 54); font-weight: 700;\"\u003e+ CS\u003c/strong\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eVAS/10\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 5.6\u0026thinsp;\u0026plusmn;\u0026thinsp;1.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 2.4\u0026thinsp;\u0026plusmn;\u0026thinsp;1.2\u003csup style=\"box-sizing: inherit;\"\u003ea1b2d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 2.4\u0026thinsp;\u0026plusmn;\u0026thinsp;2.1\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 2.3\u0026thinsp;\u0026plusmn;\u0026thinsp;1.3\u003csup style=\"box-sizing: inherit;\"\u003ea1b2d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 2.6\u0026thinsp;\u0026plusmn;\u0026thinsp;1.6\u003csup style=\"box-sizing: inherit;\"\u003ea1b2d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 2.4\u0026thinsp;\u0026plusmn;\u0026thinsp;1.6\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-dysmenorrhea\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.6\u0026thinsp;\u0026plusmn;\u0026thinsp;0.8\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5\u003csup style=\"box-sizing: inherit;\"\u003ea2b2d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.2\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-dyspareunia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 1.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 0.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 0.6\u0026thinsp;\u0026plusmn;\u0026thinsp;1.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 0.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.6\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 0.9\u0026thinsp;\u0026plusmn;\u0026thinsp;1.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 0.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CPP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.8\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.6\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.6\u0026thinsp;\u0026plusmn;\u0026thinsp;0.4\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.7\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.8\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.2\u0026thinsp;\u0026plusmn;\u0026thinsp;1.6\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eTV ultras/ovaries\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-normal or dysfunctional\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7(87.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5(62.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e6(75)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7(87.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5(62.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-simple cyst or small endomet\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(12.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3(37.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2(25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(12.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2(25)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-endometriomas (rvs)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e8(100)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003csup style=\"box-sizing: inherit;\"\u003ea2b2d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003csup style=\"box-sizing: inherit;\"\u003ea2b2d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003csup style=\"box-sizing: inherit;\"\u003ea2b2d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003csup style=\"box-sizing: inherit;\"\u003ea2b2d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(12.5)\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eTumor markers\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CA-125\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 80.5\u0026thinsp;\u0026plusmn;\u0026thinsp;57.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 19.5\u0026thinsp;\u0026plusmn;\u0026thinsp;10.9\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8)11.3\u0026thinsp;\u0026plusmn;\u0026thinsp;3.6\u003csup style=\"box-sizing: inherit;\"\u003ea1b2d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 24.2\u0026thinsp;\u0026plusmn;\u0026thinsp;26.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7)19.7\u0026thinsp;\u0026plusmn;\u0026thinsp;10.5\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8)19.5\u0026thinsp;\u0026plusmn;\u0026thinsp;10.5\u003csup style=\"box-sizing: inherit;\"\u003ea1b2d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CA-19-9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 44.9\u0026thinsp;\u0026plusmn;\u0026thinsp;63.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 10.9\u0026thinsp;\u0026plusmn;\u0026thinsp;8.6\u003csup style=\"box-sizing: inherit;\"\u003ea1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 6\u0026thinsp;\u0026plusmn;\u0026thinsp;3.1\u003csup style=\"box-sizing: inherit;\"\u003ea1b1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 17.2\u0026thinsp;\u0026plusmn;\u0026thinsp;22.1\u003csup style=\"box-sizing: inherit;\"\u003ea1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 12.7\u0026thinsp;\u0026plusmn;\u0026thinsp;13.8\u003csup style=\"box-sizing: inherit;\"\u003eb1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 18.7\u0026thinsp;\u0026plusmn;\u0026thinsp;26.8\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" colspan=\"3\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cstrong style=\"box-sizing: inherit; color: rgb(54, 54, 54); font-weight: 700;\"\u003e(2) Anastrozole\u0026thinsp;+\u0026thinsp;LNG-IUD\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cstrong style=\"box-sizing: inherit; color: rgb(54, 54, 54); font-weight: 700;\"\u003e+ TUGPA\u003c/strong\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eVAS/10\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 6.1\u0026thinsp;\u0026plusmn;\u0026thinsp;2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 3.1\u0026thinsp;\u0026plusmn;\u0026thinsp;3.1\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 3.6\u0026thinsp;\u0026plusmn;\u0026thinsp;2.1\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 4.9\u0026thinsp;\u0026plusmn;\u0026thinsp;2.5\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(5) 3.6\u0026thinsp;\u0026plusmn;\u0026thinsp;1.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(4) 3.1\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-dysmenorrhea\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.5\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.6\u0026thinsp;\u0026plusmn;\u0026thinsp;0.6\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.4\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.5\u0026thinsp;\u0026plusmn;\u0026thinsp;0.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.4\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-dyspareunia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.6\u0026thinsp;\u0026plusmn;\u0026thinsp;1.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.9\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.1\u0026thinsp;\u0026plusmn;\u0026thinsp;1.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.5\u0026thinsp;\u0026plusmn;\u0026thinsp;0.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.2\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CPP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.8\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.4\u0026thinsp;\u0026plusmn;\u0026thinsp;1.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.5\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.8\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eTV ultras/ovaries\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 op (28.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 op (42.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-normal or dysfunctional\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(14.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-simple cyst or small endomet\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3(42.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(14.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(14.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (75)(42.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-endometriomas (rvs)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7(100)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3(42.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e6(85.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e6(85.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5(100)(71.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(25)(14.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eTumor markers\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CA-125\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 90.4\u0026thinsp;\u0026plusmn;\u0026thinsp;37.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 69.8\u0026thinsp;\u0026plusmn;\u0026thinsp;105.7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 74\u0026thinsp;\u0026plusmn;\u0026thinsp;70.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 63.9\u0026thinsp;\u0026plusmn;\u0026thinsp;31.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(5) 71.1\u0026thinsp;\u0026plusmn;\u0026thinsp;71.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(4) 50.6\u0026thinsp;\u0026plusmn;\u0026thinsp;36.1\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CA-19-9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 58.9\u0026thinsp;\u0026plusmn;\u0026thinsp;71\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 21.3\u0026thinsp;\u0026plusmn;\u0026thinsp;16.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 64.9\u0026thinsp;\u0026plusmn;\u0026thinsp;100.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(5) 29.8\u0026thinsp;\u0026plusmn;\u0026thinsp;22.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(4) 46\u0026thinsp;\u0026plusmn;\u0026thinsp;56.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(4) 17.5\u0026thinsp;\u0026plusmn;\u0026thinsp;11.8\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cstrong style=\"box-sizing: inherit; color: rgb(54, 54, 54); font-weight: 700;\"\u003e(3) LNG-IUD, No Anastrozol\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cstrong style=\"box-sizing: inherit; color: rgb(54, 54, 54); font-weight: 700;\"\u003e+ CS\u003c/strong\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eVAS/10\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(9) 5.6\u0026thinsp;\u0026plusmn;\u0026thinsp;2.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(9) 2.9\u0026thinsp;\u0026plusmn;\u0026thinsp;2\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(9) 3.1\u0026thinsp;\u0026plusmn;\u0026thinsp;1.8\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(9) 3.5\u0026thinsp;\u0026plusmn;\u0026thinsp;1.9\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 4\u0026thinsp;\u0026plusmn;\u0026thinsp;2\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 2.8\u0026thinsp;\u0026plusmn;\u0026thinsp;1.1\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-dysmenorrhea\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.7\u0026thinsp;\u0026plusmn;\u0026thinsp;0.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.8\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.8\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003csup style=\"box-sizing: inherit;\"\u003ea1b2d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.5\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(5) 1.3\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-dyspareunia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.4\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 0.8\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 0.7\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 0.7\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 0.9\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(5) 0.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CPP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.7\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.8\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.8\u0026thinsp;\u0026plusmn;\u0026thinsp;0.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(5) 0.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eTV ultras/ovaries\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-normal or dysfunctional\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e8(88.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e8(88.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5(55.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5(62.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3(50)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-simple cyst or small endomet\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(11.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(11.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2(25)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2(33.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-endometriomas (rvs)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e9(100)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(11.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2(22.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(12.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(16.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eTumor markers\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CA-125\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(9) 56.3\u0026thinsp;\u0026plusmn;\u0026thinsp;12.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 11.4\u0026thinsp;\u0026plusmn;\u0026thinsp;7.9\u0026nbsp;\u003csup style=\"box-sizing: inherit;\"\u003ea1b2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(9)12.4\u0026thinsp;\u0026plusmn;\u0026thinsp;8.9\u003csup style=\"box-sizing: inherit;\"\u003ea2b2d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(9) 16\u0026thinsp;\u0026plusmn;\u0026thinsp;9.1\u003csup style=\"box-sizing: inherit;\"\u003ea2b2d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8)16.7\u0026thinsp;\u0026plusmn;\u0026thinsp;10.8\u003csup style=\"box-sizing: inherit;\"\u003ea1b2d2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 21.2\u0026thinsp;\u0026plusmn;\u0026thinsp;19\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CA-19-9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 38\u0026thinsp;\u0026plusmn;\u0026thinsp;19.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 10.2\u0026thinsp;\u0026plusmn;\u0026thinsp;4\u003csup style=\"box-sizing: inherit;\"\u003ea1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 14.8\u0026thinsp;\u0026plusmn;\u0026thinsp;11.3\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(8) 11.9\u0026thinsp;\u0026plusmn;\u0026thinsp;6.5\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 12.1\u0026thinsp;\u0026plusmn;\u0026thinsp;6.8\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 25.5\u0026thinsp;\u0026plusmn;\u0026thinsp;22.2\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" colspan=\"2\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cstrong style=\"box-sizing: inherit; color: rgb(54, 54, 54); font-weight: 700;\"\u003e(4) LNG-IUD, No Anastrozol\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cstrong style=\"box-sizing: inherit; color: rgb(54, 54, 54); font-weight: 700;\"\u003e+ TUGPA\u003c/strong\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eVAS/10\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 4.6\u0026thinsp;\u0026plusmn;\u0026thinsp;2.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 3.4\u0026thinsp;\u0026plusmn;\u0026thinsp;1.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 3\u0026thinsp;\u0026plusmn;\u0026thinsp;1.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 3.2\u0026thinsp;\u0026plusmn;\u0026thinsp;1.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 3.6\u0026thinsp;\u0026plusmn;\u0026thinsp;1.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(2) 4.3\u0026thinsp;\u0026plusmn;\u0026thinsp;2.5\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-dysmenorrhea\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.6\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.4\u0026thinsp;\u0026plusmn;\u0026thinsp;0.6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.3\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(1) 1\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-dyspareunia\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(4) 0.9\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 0.3\u0026thinsp;\u0026plusmn;\u0026thinsp;0.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 0.3\u0026thinsp;\u0026plusmn;\u0026thinsp;0.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(5) 0.2\u0026thinsp;\u0026plusmn;\u0026thinsp;0.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(4) 0.5\u0026thinsp;\u0026plusmn;\u0026thinsp;1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(1) 2\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CPP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.6\u0026thinsp;\u0026plusmn;\u0026thinsp;1.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0.9\u0026thinsp;\u0026plusmn;\u0026thinsp;0.7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(1) 2\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eTV ultras/ovaries\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(1 op, 14,3%)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(3 op, 42.9%)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-normal or dysfunctional\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(14.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(16.7)(14.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(50)(14.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-simple cyst or small endomet\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2(28.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(16.7)(14.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-endometriomas (rvs)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7(100)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4(57.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7(100)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7(100)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4(66.7)(57.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1(50)(14.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e\u003cem style=\"box-sizing: inherit;\"\u003eTumor markers\u003c/em\u003e:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CA-125\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7) 87\u0026thinsp;\u0026plusmn;\u0026thinsp;42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7)26.9\u0026thinsp;\u0026plusmn;\u0026thinsp;18.1\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7)26.6\u0026thinsp;\u0026plusmn;\u0026thinsp;21.9\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(7)42.2\u0026thinsp;\u0026plusmn;\u0026thinsp;37.8\u003csup style=\"box-sizing: inherit;\"\u003ea1b1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 43.2\u0026thinsp;\u0026plusmn;\u0026thinsp;24.2\u003csup style=\"box-sizing: inherit;\"\u003ea1d1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(2) 51.7\u0026thinsp;\u0026plusmn;\u0026thinsp;3.4\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-CA-19-9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 36.6\u0026thinsp;\u0026plusmn;\u0026thinsp;37.4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(5) 15.1\u0026thinsp;\u0026plusmn;\u0026thinsp;14.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(6) 12.3\u0026thinsp;\u0026plusmn;\u0026thinsp;13\u003csup style=\"box-sizing: inherit;\"\u003ea1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(5) 21.2\u0026thinsp;\u0026plusmn;\u0026thinsp;22.3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(5) 18.5\u0026thinsp;\u0026plusmn;\u0026thinsp;13.2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e(2) 18.9\u0026thinsp;\u0026plusmn;\u0026thinsp;13.7\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003ctfoot style=\"box-sizing: inherit;\"\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd colspan=\"8\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; text-align: left;\"\u003eData are n(%), mean\u0026thinsp;\u0026plusmn;\u0026thinsp;standard desviation (SD). Nonparametric tests (for two related samples) between values before treatment and at 3\u0026nbsp;m, 6\u0026nbsp;m, 9\u0026nbsp;m, 1y and 2y.- Test of ranges with Wilcoxon signs: a1\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.05, a2\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.01 ; a3\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.001. Signs test: b1\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.05, b2\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.01, b3\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.001. Mc Nemar test (for dichotomous variants): c1\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.05, c2\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.01; c3\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.001. Marginal homogeneity test: d1\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.05, d2\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.01, d3\u0026thinsp;=\u0026thinsp;p \u0026lt;\u0026thinsp;0.001. Only significant results are indicated. DT, during treatment; AT, after treatment; CS, conservative surgery; TUGPA, transvaginal ultrasound-guided puncture-aspiration; VAS, visual analogic scale; CPP, chronic pelvic pain; TV ultras, transvaginal ultrasound; endomet, endometrioma; rvs, rectovaginal septum; op, operated.\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tfoot\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53); font-family: Roboto, BlinkMacSystemFont, -apple-system, \"Segoe UI\", Oxygen, Ubuntu, Cantarell, \"Fira Sans\", \"Droid Sans\", \"Helvetica Neue\", Helvetica, Arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;'\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style='box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53); font-family: Roboto, BlinkMacSystemFont, -apple-system, \"Segoe UI\", Oxygen, Ubuntu, Cantarell, \"Fira Sans\", \"Droid Sans\", \"Helvetica Neue\", Helvetica, Arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;'\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cdiv class=\"gridtable\" style='box-sizing: inherit; color: rgb(74, 74, 74); font-family: Roboto, BlinkMacSystemFont, -apple-system, \"Segoe UI\", Oxygen, Ubuntu, Cantarell, \"Fira Sans\", \"Droid Sans\", \"Helvetica Neue\", Helvetica, Arial, sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;'\u003e\n \u003ctable border=\"1\" style=\"box-sizing: inherit; border-collapse: collapse; border-spacing: 0px;\"\u003e\n \u003ccaption style=\"box-sizing: inherit;\"\u003e\n \u003cdiv class=\"CaptionNumber\" style=\"box-sizing: inherit;\"\u003eTable 3\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\" style=\"box-sizing: inherit;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eFertility and clinical status in last control of the patients included in the clinical trial.\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead style=\"box-sizing: inherit;\"\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eVariable\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eGr. 1.\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eA\u0026thinsp;+\u0026thinsp;LNGIUD\u0026thinsp;+\u0026thinsp;CS [n\u0026thinsp;=\u0026thinsp;8]\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eGr. 2.\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eA\u0026thinsp;+\u0026thinsp;LNGIUD+\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eTUGPA [n\u0026thinsp;=\u0026thinsp;7]\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eGr. 3.\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eLNGIUD\u0026thinsp;+\u0026thinsp;CS [n\u0026thinsp;=\u0026thinsp;9]\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eGr. 4.\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eLNGIUD+\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eTUGPA [n\u0026thinsp;=\u0026thinsp;7]\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; color: rgb(54, 54, 54);\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eTotal CT [N\u0026thinsp;=\u0026thinsp;31]\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody style=\"box-sizing: inherit;\"\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eYears until last control\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4.4\u0026thinsp;\u0026plusmn;\u0026thinsp;1.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e5\u0026thinsp;\u0026plusmn;\u0026thinsp;1,5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3,4\u0026thinsp;\u0026plusmn;\u0026thinsp;1,3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4,2\u0026thinsp;\u0026plusmn;\u0026thinsp;1,3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4,2\u0026thinsp;\u0026plusmn;\u0026thinsp;1,7\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eInfertility\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (12.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (28,6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (11,1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4 (12,9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003ePregnancies/deliveries\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (14,3)\u003csup style=\"box-sizing: inherit;\"\u003ex\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (11,1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (14,3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (9,7)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003eClinical status in last control:\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1. Reoperated:\u003c/p\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-new CS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4 (57.1)*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3 (42.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7 (22.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e-Hyst\u0026thinsp;+\u0026thinsp;Adnexectomy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (11.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (3.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2. Persist, well, taking OCP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (12.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (28.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e0-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (28.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e4 (12.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e3. Well without medication\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e7 (87.5)*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e1 (14.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e8 (88.9)**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e2 (28.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top;\"\u003e\n \u003cp style=\"box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53);\"\u003e19 (61.3)***\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003ctfoot style=\"box-sizing: inherit;\"\u003e\n \u003ctr style=\"box-sizing: inherit;\"\u003e\n \u003ctd colspan=\"6\" style=\"box-sizing: inherit; padding: 0px; vertical-align: top; text-align: left;\"\u003eData are n(%) and mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD.\u0026nbsp;\u003csup style=\"box-sizing: inherit;\"\u003ex\u003c/sup\u003e,1 case reoperation and then pregnancy. Statistical study.- H of Kruskal-Wallis: * between gr1 and gr2 p.\u0026nbsp;004, ** between gr3 and gr4 p.\u0026nbsp;027. - *** Chi-square Pearson among the 4 groups, p.\u0026nbsp;019. A, anastrozole; CT, clinical trial; CS, conservative surgery; Hyst, hysterectomy.\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tfoot\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style='box-sizing: inherit; margin: 0px; padding: 0px 0px 10px; font-weight: 400; font-size: 0.925rem; letter-spacing: 0.35px; line-height: 1.65rem; color: rgb(36, 44, 53); font-family: Roboto, BlinkMacSystemFont, -apple-system, \"Segoe UI\", Oxygen, Ubuntu, Cantarell, \"Fira Sans\", \"Droid Sans\", \"Helvetica Neue\", Helvetica, Arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-style: initial; text-decoration-color: initial;'\u003e\u0026nbsp;\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Aromatase inhibitors, Anastrozole, levonorgestrel-IUD, endometriosis, endometriomas, clinical trial","lastPublishedDoi":"10.21203/rs.3.rs-51837/v4","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-51837/v4","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e To study the effectiveness of an aromatase inhibitor (Anastrozole) associated to levonorgestrel-releasing intrauterine device (LNG-IUD, Mirena®) in the treatment of endometriosis.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eProspective, randomized clinical trial. Setting: University Hospital (single center). Elegibility criteria: Endometriomas \u0026gt;3×4 cm, CA-125\u0026gt;35 U/mL and endometriosis symptoms. Patients: Thirty-one women randomized to anastrozole+Mirena®+Conservative Surgery(CS) (n=8), anastrozole+Mirena®+transvaginal ultrasound-guided puncture-aspiration (TUGPA) (n=7), Mirena®+CS (n=9), or Mirena®+TUGPA (n=7). Interventions: Anastrozole 1 mg/day and/or only Mirena® for 6 months; CS (ovarian and fertility-sparing) or TUGPA of endometriomas one month after starting medical treatment. Main Outcome Measures: Visual analogic scale for symptoms, CA-125 levels, ultrasound findings of endometriomas and recurrences. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e A significant improvement in symptoms during the treatment (difference of 43%, 95% CI 29.9-56.2) occurred, which was maintained at 1 and 2 years. It was more significant in patients treated with anastrozole (51%, 95% CI 33.3-68.7). For CA-125, the most significant decrease was observed without anastrozole (73.8%, 95% CI 64.2-83.4 vs. 53.8%, 95% CI 25.7-81.6 under Mirena®+anastrozole). After CS for endometriosis, a reduction of findings of endometriomas and long-term recurrences occurred, with or without anastrozole. At 4,2±1,7 years (95% CI 3,57-4,85), 88% of the patients who underwent CS were asymptomatic, without medication or reoperation, compared to only 21% if TUGPA was performed, with or without anastrozole (p=0.019). \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions:\u003c/strong\u003e Dosing anastrozole for 6 months, starting one month before CS of endometriosis, reduces more significantly the painful symptoms and delays recurrences, but has no other significant advantages over the single insertion of LNG-IUD (Mirena®) during the same time. Anastrozole and/or only Mirena® associated with TUGPA are not effective.\u003c/p\u003e","manuscriptTitle":"Anastrozole and Levonorgrestrel-Releasing Intrauterine Device in the Treatment of Endometriosis: A Randomized Clinical Trial.","msid":"","msnumber":"","nonDraftVersions":[{"code":4,"date":"2020-12-28 10:59:04","doi":"10.21203/rs.3.rs-51837/v4","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2021-03-10T00:00:00+00:00","index":2,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\n I read with great interest the manuscript titled as ' Anastrozole and Levonorgrestrel-Releasing Intrauterine Device in the Treatment of Endometriosis: A Randomized Clinical Trial'.\n Despite the small sample size, the manuscript is well written and the study design is well described.\n In the revised form of manuscript, authors completely responded to comments and I have no additional suggestion.\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons after the final decision on the manuscript has been made. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"decision","content":"Major revision","date":"2021-03-10T00:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2021-01-06T00:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-12-18T00:00:00+00:00","index":1,"fulltext":"Recommendation: Major revisions required\nForm responses:\n---\n\nComments to Author:\n---\nDear Respectable Editor\nThank you to give me the opportunity to review the article entitled (Anastrozole and Levonorgrestrel-Releasing Intrauterine Device in the Treatment of Endometriosis: A Randomized Clinical Trial)\nIts an interesting, and well-designed article, which discussing very important subject.\nI am also proud by the scientific content and value of the article and by the effort done by the authors through this article.\nI suggest major revision before acceptance for publication.\nPlease, see the attached PDF file of the reviewed article and the paragraph and sentence need correction where highlighted in that file to make the article easy for the readers\nregards\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons after the final decision on the manuscript has been made. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no conflict of interests in relation to this article**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-12-15T00:00:00+00:00","index":1,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-12-14T00:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-12-10T00:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-12-09T23:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-12-09T23:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":3,"date":"2020-12-07 21:20:10","doi":"10.21203/rs.3.rs-51837/v3","editorialEvents":[{"type":"communityComments","content":0},{"type":"reviewerAgreed","content":"","date":"2020-11-23T01:00:00+00:00","index":2,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-11-23T00:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-11-23T00:00:00+00:00","index":1,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-11-23T00:00:00+00:00","index":1,"fulltext":"Recommendation: Reviewer's comments unavailable pending editorial decision\n"},{"type":"editorAssigned","content":"","date":"2020-11-22T00:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-11-21T23:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-11-21T23:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":2,"date":"2020-10-29 17:11:11","doi":"10.21203/rs.3.rs-51837/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"reviewerAgreed","content":"","date":"2020-10-27T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-10-25T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-10-25T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-10-25T12:00:00+00:00","index":1,"fulltext":"Recommendation: Reviewer's comments unavailable pending editorial decision\n"},{"type":"editorAssigned","content":"","date":"2020-10-23T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-10-22T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-10-22T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-08-27 15:16:25","doi":"10.21203/rs.3.rs-51837/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2020-10-05T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-10-04T12:00:00+00:00","index":1,"fulltext":"Recommendation: Major revisions required\nForm responses:\n---\n\nComments to Author:\n---\nDear Authors,thank you very much for the opportunity to review your manuscript. The article reports the results of a randomized trial regarding the use of anastrazole .\nFirst of all, the main concern regards the enrollment criteria, in fact, giving only the lower boundaries of the criteria the population can be very heterogeneous, for example, the CA125 can be either 36 or 190, the OMA can be either 4 cm or 7 cm, and these situations are very different. Similarly can be said for VAS 5 or VAS 10.\nMoreover the history and duration of symptomps can impact treatment as well and this sentence \"These patients could have a previous diagnosis and treatment (medical and/or surgical) of endometriosis, but they should not have received medical treatment in the last 3 months.\" is not enough to avoid a bias.\nThere is no mention regarding the randomization process and the calculation of the sample size, and no data has been reported to describe the main outcome of the study (beside the cited studies). The authors reports too many groups in a very small population, in fact there are 4 independent variables tested. The problem is related to the embalacing derived from the multiple subgrouping and the total lack of statistical power, owing to inconclusive results, and not even suitable for post-hoc hypotesis.\nThe incipit of the discussion \"Our study shows that oral administration of 1 mg/day Anastrozole for 6 months, beginning before CS intervention of endometriosis, reduces or improves significantly the symptoms associated with the\ndisease (especially dysmenorrhea and CPP) during and after treatment. No other significant advantages\nover the single insertion of LNG-IUD (Mirena®), prior to CS, were observed. The recurrence and\nreoperation rates were similar at 2 years with or without Anastrozole that were adversely influenced by\nthe performance of TUGPA.\" van't be written as it is given only 31 patients enrolled. A similar limitation can be raised for this sentence \"Clearly, the worst result in short and long term was the performance of TUGPA (instead of CS), independently of the use of Anastrozole and Mirena®.\" because authors report group crossed TUGPA results in even a smaller population, without not even a sample size or a prespecified subgrouping, and obiously, this sentence can't be \"Clearly\", but it's almost an impression.\nThe authors define this study a pilot study, and hence I strongly suggest to change the title and to decrease the importance of the findings and to rewrite the discussion to put the basis of a rationale for a future study, highlight that TUGPA should not be used to avoid jeopardization of the results. Moreover I strongly suggest to report the sample size calculation and the main outcome expected.\nAlso the highlights are too much for the study, for example point 3, 4 and 5 are well far to be declared from the results of the study, since this points are subjective comments and not based on a sample size calculation or a post hoc hypotesis.\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **None**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **No**\n* Are the methods sufficiently described to allow the study to be repeated?: **No**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-09-23T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-23T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nI read with great interest the manuscript, which falls within the aim of this Journal. In my honest opinion, the topic is interesting enough to attract the readers' attention. Nevertheless, authors should clarify some points and improve the discussion, as suggested below.\nAuthors should consider the following recommendations:\n- Manuscript should be further revised in order to correct some typos and improve style.\n- Accumulating evidence suggests that immune cells, adhesion molecules, extracellular matrix metalloproteinase and pro-inflammatory cytokines activate/alter peritoneal microenvironment, creating the conditions for differentiation, adhesion, proliferation and survival of ectopic endometrial cells. I would discuss these points in the light of new theories about the pathogenesis of endometriosis, referring to: PMID: 31717614; PMID: 31663401; PMID: 28571791.\n- Although peritoneal superficial lesions and ovarian endometriomas represent the majority of endometriotic implants within the pelvis, deep infiltrating endometriosis and extrapelvic endometriosis are the most challenging conditions to face off. Despite sometimes medical therapy is enough to reduce symptoms and signs (PMID: 28537213; PMID: 30074068), in a large number of patients a complete eradication, with nerve-sparing and vascular sparing approach (PMID: 27579309; PMID: 30415128) is needed to restore the normal pelvic anatomy and its functions. I would add few lines to discuss these points, referring to the abovementioned works.\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests.**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-09-14T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-09-03T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-08-21T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-08-20T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-08-20T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-womens-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bmwh","sideBox":"Learn more about [BMC Women's Health](http://bmcwomenshealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bmwh/default.aspx","title":"BMC Women's Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"12bc98dc-adce-4f53-8d99-2d0441109439","owner":[],"postedDate":"December 28th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":1370982,"name":"Obstetrics \u0026 Gynecology"}],"tags":[],"updatedAt":"2021-07-27T20:54:31+00:00","versionOfRecord":{"articleIdentity":"rs-51837","link":"https://doi.org/10.1186/s12905-021-01347-9","journal":{"identity":"bmc-womens-health","isVorOnly":false,"title":"BMC Women's Health"},"publishedOn":"2021-05-20 20:54:31","publishedOnDateReadable":"May 20th, 2021"},"versionCreatedAt":"2020-12-28 10:59:04","video":"","vorDoi":"10.1186/s12905-021-01347-9","vorDoiUrl":"https://doi.org/10.1186/s12905-021-01347-9","workflowStages":[]},"version":"v4","identity":"rs-51837","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-51837","identity":"rs-51837","version":["v4"]},"buildId":"WvIrzKhiLBfengagbw6Ux","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}