Immunohistochemical detection of heparanase-1 expression in eutopic and ectopic endometrium from women with endometriosis

Xu X, Xiulong Xu, Ding J, Jianchi Ding, Ding H, Helen Ding, Shen J, Jikun Shen, Paolo Gattuso, Gattuso P, Richard A. Prinz, Prinz RA, Rana N, Nasir Rana, W. Paul Dmowski, Dmowski WP
Fertility and sterility · 2007 · vol. 88(5) , pp. 1304–1310 · doi:10.1016/j.fertnstert.2006.12.081 · PMID:17481627 · W2084376565
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This study investigated heparanase-1 expression in endometrial tissue from women with and without endometriosis.

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Abstract

OBJECTIVE: To investigate the expression of heparanase-1, an endoglycosidase that degrades heparan sulfate proteoglycans, in eutopic and ectopic endometrial tissues from women with endometriosis. DESIGN: An immunohistochemical study. SETTING: Academic research laboratory and a private infertility clinic affiliated with a university medical center. PATIENT(S): Premenopausal women undergoing laparoscopy for endometriosis. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Expression of heparanase-1 analyzed by immunohistochemical staining in 91 eutopic and 14 ectopic endometrial specimens. RESULT(S): We found that 17% (4/24) of the eutopic endometrial specimens in the early proliferative phase and 32% (9/28) of the samples in the midproliferative phase were heparanase-1 positive. However, >or=80% of eutopic endometrial specimens at late proliferate phase and at luteal phase were heparanase-1 positive. Twelve of 14 ectopic endometriotic specimens stained heparanase-1 positive. Comparison of heparanase-1 expression in paired eutopic and ectopic endometrial tissues revealed that 5 of 6 ectopic specimens in the early proliferative phase were heparanase-1 positive, whereas only 1 eutopic specimen was heparanase-1 positive. In comparison with our recent study of heparanase-1 expression in normal endometrium, we found that there was no significant difference in heparanase-1 expression in the eutopic endometrium from women with or without endometriosis. CONCLUSION(S): Heparanase-1 was differentially expressed in the eutopic endometrium in the different menstrual phases. Heparanase-1 was highly expressed in the ectopic endometriotic lesions regardless of their menstrual phases, suggesting that the local environment is responsible for increased heparanase-1 expression.

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Condition tags

endometriosis

MeSH descriptors

Choristoma Endometriosis Endometrium Endometrium Gene Expression Regulation, Enzymologic Glucuronidase Adult Adult Choristoma Choristoma Choristoma Endometriosis Endometriosis Endometriosis Female Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Enzymologic Glucuronidase Glucuronidase

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