Circ_0001495 influences the development of endometriosis through the miRNA-34c-5p/E2F3 axis

Yue Y, Yan Yue, Bin Lu, Lu B, Bin Lü, Ni G, Guantai Ni
Reproductive biology · 2024 · vol. 24(2) , pp. 100876 · doi:10.1016/j.repbio.2024.100876 · PMID:38458026 · W4392573738
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This study found that circ_0001495 promotes endometriosis by regulating E2F3 via the miR-34c-5p axis, inhibiting proliferation and migration while increasing apoptosis of ectopic endometrial stromal cells.

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Abstract

Endometriosis is a chronic gynecological condition characterized by the presence of endometrial glands and stroma outside the uterine cavity., accounting for 7% of all female malignant tumors and 20%- 30% of malignant tumors of the female reproductive system. Multiple studies have shown that circular RNA (circRNA) has the potential to become a targeted target and marker for EM. However, the roles of circ_0001495 in EM are still unclear. Our research aims to reveal the molecular mechanism of circ_0001495 in EM. In this study, RT-PCR or western blot were conducted to determine mRNA and protein expression. cell viability, proliferation, migration, invasion, and apoptosis were assessed by CCK-8, EdU, wound healing, transwell, and flow cytometry analyses, respectively. Additionally, the targeting relationship between miR-34c-5p and circ_0001495 or E2F3 was confirmed through dual-luciferase reporter gene assay. We found significant overexpression of circ_0001495 in EM tissues and cells. Knockdown of circ_0001495 inhibited the proliferation, migration and invasion of ectopic endometrial stromal cells (EESCs) and increased cell apoptosis. Moreover, we found that circ_0001495 regulated E2F3 levels by interacting with miR-34c-5p in EESC. Furthermore, in vitro, miR-34c-5p inhibition or E2F3 overexpression could attenuate the effect of circ_0001495 silencing on EM progression. In addition, the vivo experiment demonstrated that inhibition of circ_0001495 could repress the development of endometriosis by regulating the miR-34c-5p/E2F3 axis. In conclusion, our study suggested that circ_0001495 promoted EM progression in vitro and in vivo through the miR-34c-5p/E2F3 axis, which might be a potential therapeutic target for EM.

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Condition tags

endometriosis

MeSH descriptors

E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor E2F3 Transcription Factor

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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