Immunohistochemical expression of matrix metalloproteinases, their tissue inhibitors, and cathepsin-D in ovarian endometriosis: correlation with severity of disease

Protopapas A, Αθανάσιος Πρωτόπαπας, Athanasios Protopapas, Markaki S, S. Markaki, Sophia Markaki, Theodoros Mitsis, Mitsis T, Dimitrios Milingos, Milingos D, Stavros Athanasiou, Dimitrios Haidopoulos, Haidopoulos D, Dimitrios Loutradis, Loutradis D, Aris Antsaklis, Antsaklis A
Fertility and sterility · 2010 · vol. 94(6) , pp. 2470–2472 · doi:10.1016/j.fertnstert.2010.03.007 · PMID:20385381 · W2070751717
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This study examined the immunohistochemical expression of matrix metalloproteinases, their tissue inhibitors, and cathepsin-D in ovarian endometriosis and its correlation with disease severity.

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Abstract

In this study the immunohistochemical expression of matrix metalloproteinases 1, 2, 3, and 9, tissue inhibitors (TIMPs) 1 and 2, and cathepsin-D in ovarian endometriomas were correlated with the clinical severity of endometriosis (i.e., presence of chronic pelvic pain [CPP] and American Society of Reproductive Medicine [ASRM] scores). Positive expression of proteases and their inhibitors was found more frequently in cases with low ASRM scores, whereas presence of CPP correlated significantly with absence of expression of TIMPs 1 and 2, indicating, first, that production of these enzymes is more active during the initial phases of the evolution of ovarian endometriosis, declining as fibrosis develops, and second, that expression of TIMPs seems to play a role in the development of CPP.

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Condition tags

endometriosis

MeSH descriptors

Cathepsin D Endometriosis Matrix Metalloproteinases Ovarian Diseases Tissue Inhibitor of Metalloproteinases Adolescent Adult Biomarkers Biomarkers Case-Control Studies Cathepsin D Endometriosis Endometriosis Endometriosis Female Humans Immunohistochemistry Matrix Metalloproteinases Ovarian Diseases Ovarian Diseases

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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