What abdominal radiologists should know about extragenital endometriosis-associated neuropathy

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AI-generated summary by claude@2026-06+body, 2026-06-07

This pictorial essay reviews pelvic nerve anatomy and imaging features of endometriosis-associated neuropathy, presenting clinical findings and MRI characteristics of seven patients with this rare condition.

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AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text

This pictorial essay reviews pelvic peripheral nerve anatomy and imaging features of endometriosis-associated neuropathy, evaluating clinical findings, MRI appearances, and outcomes in seven patients. The authors report that nerve involvement by endometriosis is rare and can present with neurological pain, muscle weakness, bowel and bladder incontinence, or paraplegia, either isolated or via direct extension of deep infiltrating endometriosis; MRI is described as a reliable modality, with key findings including retractile fibrous tissue and endometriomas whose signal varies with hemorrhage age and tissue composition. A stated limitation is that the evidence is based on a small case series (seven patients) rather than larger comparative data. This paper is centrally about endometriosis — specifically extragenital endometriosis-associated neuropathy and how abdominal radiologists should recognize it on MRI.

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Abstract

Purpose The aim of this study is to provide an overview of endometriosis-associated neuropathy and to review main anatomical concepts of intrapelvic peripheral nerves.

Methods

In this pictorial essay, we review the anatomy of pelvic nerves and imaging features of endometriosis-associated neuropathy. We also evaluate clinical findings, imaging features, and outcome of seven patients with endometriosis-associated neuropathy.

Results

Nerve involvement by endometriosis is rare and may manifest with neurological symptoms, including pain, muscle weakness, bowel and bladder incontinence, and paraplegia. The neural involvement may be isolated or caused by a direct extension of a deep infiltrating endometriosis of the pelvic structure. Magnetic resonance imaging (MRI) is a reliable imaging modality for detecting neural involvement of endometriosis. On MRI, the main imaging features are retractile fibrous tissue and endometriomas. The signal intensity of the endometriotic tissue may vary depending on the age of the hemorrhage and the proportion of endometrial cells and stroma. Early diagnosis and treatment may avoid permanent neural damage.

Conclusion

Considering that patients with endometriosis usually undergo pelvic MRI, which is generally reported by a non-musculoskeletal-trained radiologist, abdominal radiologists need to be familiar with the pelvic nerve anatomy and the possible patterns of presentation of neural endometriosis. Early diagnosis may obviate permanent nerve damage and MRI is a reliable tool for the diagnosis. Similar content being viewed by others

References

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What abdominal radiologists should know about extragenital endometriosis-associated neuropathy. Abdom Radiol 45, 1818–1828 (2020). https://doi.org/10.1007/s00261-018-1864-x Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00261-018-1864-x

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Abdomen Female Humans Magnetic Resonance Imaging Pelvis Radiologists

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