Causes of endometriosis and prevalent infertility in patients undergoing laparoscopy without achieving pregnancy

Renato de Oliveira, de Oliveira R, Fernando Adami, Fernanda A Mafra, Fernanda Mafra, Mafra FA, Bianca Bianco, Bianco B, Vilarino F.L, Fabia Lima Vilariño, Fabia L Vilarino, Caio P Barbosa, Caio Parente Barbosa, Barbosa CP
Minerva ginecologica · 2016 · vol. 68(3) , pp. 250–8 · PMID:26126067 · W2415319214
Observational OA: closed CC0 ⤵ 12 in-corpus citations
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Endometriosis in infertile patients undergoing laparoscopy was associated with polyps and fibroids, with fibroids linked to higher endometriosis grades and PCOS linked to lower grades.

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Abstract

BACKGROUND: Endometriosis is a disease with an unknown pathogenesis that can lead to infertility. Endometrial polyps, fibroids, and polycystic ovarian syndrome (PCOS) have relatively high frequency and are causes of infertility. We hypothesized a possible relationship between the presence of polyps, fibroids, and PCOS in infertile women with endometriosis who underwent laparoscopy and did not get pregnant, compared to women in the control group. METHODS: This study was a cross-sectional study of 1243 infertile patients (621 with endometriosis and 622 controls). Endometriosis, Body Mass Index (BMI), infertility duration, age, and smoking habits were analyzed in relation to the presence of endometrial polyps, fibroids, and PCOS. RESULTS: Polyps, 1.8 (95% CI 1.3-2.5); fibroids, 2.5 (95% CI 1.5-4.1); and PCOS, 1.0 (95% CI 0.6-1.6 were observed in the endometriosis group. A total of 285 patients (45.9%) were classified presenting endometriosis grades I and II, and 336 patients (54.1%) with grades III and IV. Our findings showed a significant association between the presence of fibroids in 129 women with endometriosis (20.8%), and in 69 (53.9%) with endometriosis grades III and IV (P=0:04). Among the 31 PCOS patients, 24 (77.4%) showed grades I and II (P<0.001). CONCLUSIONS: Endometriosis and infertility are associated with the presence of polyps and fibroids. Furthermore, associations between the presence of fibroids with endometriosis grades III and IV, and presence of PCOS with grades I and II were observed.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Laparoscopy Adult Adult Cross-Sectional Studies Cross-Sectional Studies Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Infertility, Female Infertility, Female Infertility, Female Laparoscopy Laparoscopy

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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