Comparative systems genetics view of endometriosis and uterine leiomyoma: Two sides of the same coin?

Vladislav S Baranov, В. С. Баранов, Ivaschenko TE, Tatyana E Ivaschenko, T. Ivaschenko, Maria I. Yarmolinskaya
Systems biology in reproductive medicine · 2016 · vol. 62(2) , pp. 93–105 · doi:10.3109/19396368.2015.1123325 · PMID:26828864 · W2272145904
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This study comparatively analyzes gene networks, expression, and epigenetics of endometriosis and uterine leiomyoma, revealing molecular similarities that support a hypothesis of shared mesenchymal stem cell origins.

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Abstract

Endometriosis (EM) and uterine leiomyoma (UL) are two most frequent benign tumors of monoclonal origin affecting about 30% of all women in their reproductive age. Modern molecular technologies have made a tremendous impact in understanding both disorders. Here is the first comparative analysis of molecular mechanisms underlying development of EM and UL as it looks from the platform of systems genetics. Similarities and differences of EM and UL at their incipient stages are enlightened with special emphasis on their gene networks, gene expression, and epigenetic regulation, of pathologic development. The analysis substantiates a new hypothesis postulating tumors as outgrowths of the stem cells with mesenchymal commitment lineage (mSC) which migrate from the endometrium/myometrium junctional zone of the uterus. Comparative analysis has revealed basic similarities of molecular pathogenesis of EM and UL suggesting molecular syntropy of both disorders. Peculiarities of the epigenetic landscape determining development of mSC may explain the existence of different clinical forms of EM and UL as well as their unique clinical manifestation. Some perspectives for practical and scientific application in EM and UL studies of this new hypothesis are outlined.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Leiomyoma Uterine Neoplasms Cell Differentiation Cell Differentiation Cell Transformation, Neoplastic Cell Transformation, Neoplastic Cell Transformation, Neoplastic Endometriosis Endometriosis Endometriosis Epigenesis, Genetic Epigenesis, Genetic Female Female Gene Regulatory Networks Gene Regulatory Networks Humans Humans Leiomyoma

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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