Nucleolar organizer regions in endometriosis, atypical endometriosis, and clear cell and endometrioid carcinomas

Chalas E, E Chalas, Eva Chalas, John ChumasS, Chumas J, J Chumas, Barbieri R, R Barbieri, Robert L. Barbieri, W J Mann, Mann WJ, William J. Mann
Gynecologic Oncology · 1990 · vol. 40(3) , pp. 260–263 · doi:10.1016/0090-8258(90)90288-v · PMID:2013450 · W2036844673
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Silver-stained nucleolar organizer regions (AgNORs) were counted in endometriosis, atypical endometriosis, and carcinomas, revealing significantly increasing counts across these conditions and identifying a critical count that predicted malignancy in atypical endometriosis.

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Abstract

Nucleolar Organizer Regions (NORs) code for ribosomal RNA and are thought to be an accurate representation of the percentage of cells in S-phase. NORs are associated with nonhistone nucleoproteins, which can be stained with silver (AgNORs). An increased number of AgNORs has been observed in many malignancies. AgNORs were counted in three groups of patients with endometriosis (Group I), atypical endometriosis (Group II), and clear cell or endometrioid carcinomas (Group III) to assess the malignant potential of atypical endometriosis. Each group consisted of 10 patients. Mean AgNOR counts were 5.83 (Group I), 7.68 (Group II), and 15.42 (Group III). The results were analyzed and were significantly different for all groups (P less than 0.05 for Groups I and II, P less than 0.02 for Groups II and III, and P less than 0.01 for Groups I and III). A critical AgNOR count of 8.20 was calculated utilizing AgNOR counts from Group I. Three of the four patients with AgNORs greater than 8.20 and atypical endometriosis developed a malignancy. AgNOR counts provide useful information, represent an inexpensive test which can be obtained from fixed tissue, and may aid in clinical management of patients with atypical endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Endometriosis Nucleolus Organizer Region Adenocarcinoma Adenocarcinoma Endometriosis Endometriosis Humans Humans Nucleolus Organizer Region Nucleolus Organizer Region Prognosis Prognosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (18)

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