Neuroticism and cognitive correlates of depression and anxiety in endometriosis: A meta-analytic review, evidence appraisal, and future recommendations

R A Davenport, Rebekah Davenport, I Krug, Isabel Krug, Krug I, Phuong Linh Dang, P L Dang, Rickerby N, Nicole Rickerby, N Rickerby, L Kiropoulos, Litza Kiropoulos
Journal of Psychosomatic Research · 2024 · vol. 187 , pp. 111906 · doi:10.1016/j.jpsychores.2024.111906 · PMID:39236356 · W4402029238
Systematic review / meta-analysis OA: hybrid CC0 ⤵ 5 in-corpus citations
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This meta-analysis found that rumination, pain catastrophizing, and illness perceptions of low control are associated with depression in endometriosis, while research on personality traits and anxiety remains limited.

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Abstract

OBJECTIVE: This meta-analytic review aimed to synthesise evidence on personality and cognitive factors related to depression and anxiety in endometriosis and determine whether sociodemographic and clinical variables moderate factor-symptom relations. Additionally, this review aimed to evaluate the quality of research and formulate recommendations for future research. METHODS: A systematic search was conducted across databases (Medline, Embase, PsycInfo, Web of Science, ProQuest) through to February 2024. Search terms were used for endometriosis, depression, anxiety, cognitive factors and personality traits. Random-effects meta-analyses were conducted to produce pooled weighted effects (r) for factor-symptom relationships. RESULTS: Thirteen studies (11 samples; N = 3287; Mage 33.89 ± 2.48) were included in a narrative synthesis. One study provided evidence for a positive association between neuroticism and depression. Seven studies contributed to meta-analyses on three cognitive factors. Medium-to-large associations were identified between illness perceptions of low control/power (r = 0.35, 95 % CI: 0.01,0.62), rumination (r = 0.52, 95 % CI: 0.09, 0.78), pain-catastrophising (r = 0.37, 95 % CI: 0.28, 0.45) and higher levels of depression. The statistical power to detect significant effects was >80 %. Findings for anxiety were non-significant, although limited data were available. Quality appraisal revealed a high risk of within-study bias (4.69 ± 1.38, range: 3-7), with issues related to sample representativeness and measurement selection. CONCLUSION: Rumination, pain-catastrophising, and illness perceptions of low control/power are important in understanding depression in endometriosis. There is a lack of research on personality traits, necessitating further study. Findings highlight the importance of prioritising modifiable cognitive factors in psychological research and clinical practice in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression Depression

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (7)

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