Treatment of benign breast disease with danazol: a follow-up report

Aksu MF, M F Aksu, Tzingounis VA, V A Tzingounis, Greenblatt Rb, R. B. Greenblatt
The Journal of reproductive medicine · 1978 · vol. 21(3) , pp. 181–4 · PMID:722702 · W2285714321
Non-randomised trial OA: closed CC0 ⤵ 5 in-corpus citations
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Danazol treatment of benign breast disease provided significant relief of pain, tenderness, and nodosities, with low recurrence rates and a notable incidence of conception in infertile patients.

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Abstract

One hundred thirty-five women with benign breast disease (BBD) were treated with danazol, an impeded androgen. Their ages ranged from 19 to 60 years (mean age, 30). The dose varied from 100 to 800 mg per day for 90 to 180 days, depending upon the severity of the disorder. Overall relief of pain was observed in 97% and of tenderness in 90.5%. There was complete or marked improvement of nodosities in 73%. Seventy-eight patients were followed every six months for two to four years. The recurrent symptoms were pain in 6%, tenderness in 6% and nodosities in 10%. Incidentally, we found that 29.3% of infertile women with BBD conceived within 24 months after cessation of a course of therapy. The side effects, when present, were trivial.

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Condition tags

endometriosis

MeSH descriptors

Breast Diseases Danazol Pregnadienes Adult Adult Breast Diseases Breast Diseases Danazol Danazol Danazol Endometriosis Endometriosis Endometriosis Female Female Follow-Up Studies Follow-Up Studies Humans Humans Menstruation

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License: CC0 · commercial use OK