Therapeutic effects of leuprorelin microspheres on endometriosis and uterine leiomyomata

Anderson MG, James D. Miller, MG Anderson, JD Miller, Michael G. Anderson, Miller JD
Advanced drug delivery reviews · 1997 · vol. 28(1) , pp. 139–155 · doi:10.1016/s0169-409x(97)00055-0 · PMID:10837569 · W2031905134
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Depot microspheres of leuprorelin acetate provide efficacious, safe, and well-tolerated medical management for both endometriosis and uterine leiomyomata, overcoming the poor compliance associated with earlier GnRH agonist formulations.

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Abstract

Uterine leiomyomata and endometriosis are two common hormone-dependent pathologies effecting women of reproductive age. Prior to the introduction of gonadotropin releasing hormone agonists (GnRHa), there was no effective medical therapy for leiomyomata, and the most effective pharmaceutical intervention for endometriosis had unacceptable side effects. Early intranasal and non-depot formulations of GnRHa were effective treatments for these diseases but patient acceptance and compliance was poor. The introduction of depot microspheres of leuprorelin (leuprolide) acetate has provided efficacious and safe medical management of both endometriosis and uterine leiomyomata which is well tolerated by most patients.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (87)

Cited by (1)

SciLite annotations

chemicals 5
goserelin maghemite nanoparticle goserelin leuprolide acetate
organisms 1
noordeloos 2009062

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