Reduction of Adhesion Reformation After Laparoscopic Endometriosis Surgery: A Randomized Trial With an Oxidized Regenerated Cellulose Absorbable Barrier
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An oxidized regenerated cellulose barrier significantly reduced adhesion reformation after laparoscopic surgery for endometriosis compared to surgery alone in a randomized trial.
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Abstract
OBJECTIVE: To evaluate the effectiveness of an oxidized regenerated cellulose absorbable barrier (Interceed [TC7] Absorbable Adhesion Barrier) in the reduction of adhesion reformation after laparoscopic surgery for endometriosis. METHODS: Thirty-two premenopausal nonpregnant women who had severe endometriosis and complete posterior cul-de-sac obliteration and were undergoing laparoscopic surgery were randomly assigned to either surgery alone or surgery and Interceed. None of the subjects received any other treatment for adhesion prevention. Second-look laparoscopy was performed 12-14 weeks after laparoscopic surgery by an investigator blinded to the treatment, and the incidence of adhesion-free subjects was assessed. RESULTS: Twelve of 16 (75%) women treated with the oxidized regenerated cellulose barrier were free of adhesions, compared with two of 16 (12.5%) controls, a statistically significant difference (P < .05). CONCLUSION: The oxidized regenerated cellulose absorbable barrier significantly reduces adhesion reformation after laparoscopic surgery for endometriosis.
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Cited by (20)
- Adhesion prevention after endometriosis surgery — results of a randomized, controlled clinical trial with second-look laparoscopy 2021
- Adolescent Endometriosis: Fertility Outcomes 2020
- Barrier agents for adhesion prevention after gynaecological surgery 2020
- Effectiveness of ovarian suspension in preventing postoperative ovarian adhesions in patients with severe pelvic endometriosis—a case-control study 2019
- Endométriose minime à légère : résultats du traitement chirurgical sur la douleur et l’infertilité et modalités techniques. Quelles stratégies thérapeutiques ? RPC Endométriose CNGOF-HAS 2018
- Barrier agents for adhesion prevention after gynaecological surgery 2015
- Adhesion Prevention in Endometriosis: A Neglected Critical Challenge 2012
- Surgical measures for endometriosis-related infertility: A plea for research 2011
- Clinical Management of Endometriosis 2011
- Laparoscopic Management of Endometriosis: Comprehensive Review of Best Evidence 2009
- Ovarian endometrioma: postoperative adhesions following bipolar coagulation and suture 2008
- Prise en charge d'une endométriose douloureuse 2007
- Conservative surgical management of endometriosis in women with pelvic pain 2006
- La diagnosi di endometriosi 2005
- Transient abdominal ovariopexy for adhesion prevention in patients who underwent surgery for severe pelvic endometriosis 2004
- The Role of Laparoscopy in the Chronic Pelvic Pain Patient 2003
- Endometriosis, Endometrioma, and the Problem of Adhesions 2000
- 10.1016/s0246-1064(13)59715-5 2000
- Peritoneal Endometriosis 2000
- The evidence for the management of endometriosis 1998
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:11:08.331550+00:00
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