Use of Interceed(TC7) absorbable adhesion barrier to reduce postoperative adhesion reformation in infertility and endometriosis surgery. The Obstetrics and Gynecology Adhesion Prevention Committee.
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Interceed(TC7) significantly reduced the incidence and extent of postoperative adhesions following infertility and endometriosis surgeries in a randomized clinical trial.
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Abstract
Interceed(TC7) is a fabric composed of oxidized, regenerated cellulose that was designed to reduce the formation of postsurgical adhesions. We evaluated Interceed(TC7) in a randomized, multicenter clinical study. Sixty-three infertility patients had bilateral pelvic sidewall adhesions removed at laparotomy. One pelvic sidewall was covered by Interceed(TC7) and the other was left uncovered. The deperitonealized areas (N = 205) of all sidewalls were divided into three groups: less than 100 mm2, N = 72; 100-1000 mm2, N = 95; and more than 1000 mm2, N = 38. The effectiveness of Interceed(TC7) was evaluated at laparoscopy 10-98 days after laparotomy. Significantly more adhesions were observed at laparoscopy on the control pelvic sidewalls (48 of 63, 76%) than on the treated sides (26 of 63, 41%) (P less than .0001). The Interceed(TC7)-treated sidewalls also had significantly less area involved with adhesions at laparoscopy (P less than .05, P less than .001, and P less than .001 in the three groups, respectively). Twenty-eight women with severe endometriosis also had significantly more adhesions on the control side (23 of 28, 82%) than on the treated side (14 of 28, 50%) (P less than .05). We conclude that Interceed(TC7) effectively reduced the incidence and extent of postoperative adhesions, even in patients with severe endometriosis.
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Cited by (11)
- Adhesion prevention after endometriosis surgery — results of a randomized, controlled clinical trial with second-look laparoscopy 2021
- Barrier agents for adhesion prevention after gynaecological surgery 2020
- Current controversies in tubal disease, endometriosis, and pelvic adhesion 2019
- Barrier agents for adhesion prevention after gynaecological surgery 2015
- Effect of cross linked sodium hyaluronate in adhesion reduction within the gynecologic surgical window 2014
- Prise en charge d'une endométriose douloureuse 2007
- Conservative surgical management of endometriosis in women with pelvic pain 2006
- Transient abdominal ovariopexy for adhesion prevention in patients who underwent surgery for severe pelvic endometriosis 2004
- Temporary Ovarian Suspension at Laparoscopy for Prevention of Adhesions 2002
- Surgical treatment for chronic pelvic pain. 1999
- Reduction of Adhesion Reformation After Laparoscopic Endometriosis Surgery: A Randomized Trial With an Oxidized Regenerated Cellulose Absorbable Barrier 1995
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