Effects of Danchi decoction on P450AROM, survivin of eutopic endometrium of patients with endometriosis after conservative surgery

Yi‐Hsin Yang, RH Zhao, Zhengping Hao, L Li, Caiqi Xu, Cui Yy
In: African Journal of Traditional, Complementary and Alternative Medicines · 2015 · vol. 12(4) , pp. 65 · doi:10.4314/ajtcam.v12i4.10 · W4230918668
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Danchi decoction treatment following conservative endometriosis surgery reduced P450AROM and survivin expression in eutopic endometrium, similar to Western medicine treatments.

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This prospective clinical study evaluated the effects of Danchi decoction on aromatase (P450arom) and survivin expression in the eutopic endometrium of twenty patients with endometriosis following conservative surgery. Participants were randomized to receive either Danchi decoction or standard western medications, with tissue samples collected before treatment and three months later for immunohistochemical analysis. The results demonstrated that both treatments significantly reduced the elevated expressions of P450arom and survivin compared to baseline levels, achieving comparable efficacy between the traditional Chinese medicine and western medicine groups. This paper is centrally about endometriosis — specifically investigating how Danchi decoction may control recurrence by regulating these molecular markers in the eutopic endometrium.

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Abstract

Background: Endometriosis is a common gynecological disease, which can seriously affect the physical and mental health of patients. However, there is not a satisfactory way to treat endometriosis with a low recurrence rate.Materials and Methods: Including twenty patients with endometriosis given conservative surgery, a prospective clinical study was performed with randomly grouping and positive control. The traditional Chinese medicine (TCM) and western medicine (WM) groups were given Danchi decoction and GnRH-a or gestrinone respectively. Treatment was given in 1–5 days during the first menstruation. The eutopic endometriums were collected before and 3 months after the treatment, respectively. Then immunohistochemistry was performed to obtain the expressions of P450arom and survivin. In the normal control (NC) group no drugs were administered.Results: Before the treatment, the expressions of P450arom and survivin in both TCM and WM groups were much higher than the NC group (P0.05). The expressions of the two groups were remarkably decreased after the treatment (P0.05).Conclusion: Danchi decoction can control the recurrence of endometriosis by restraining abnormal secretion of aromatizing enzyme and regulating cell apoptosis in eutopic endometrium. Excessive expressions of aromatizing enzyme and decreased apoptosis are a possible mechanism of endometriosis recurrence.Key words: Endometriosis, Recurrence, Danchi Decoction, Eutopic endometrium
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Abstract

Background: Endometriosis is a common gynecological disease, which can seriously affect the physical and mental health of patients. However, there is not a satisfactory way to treat endometriosis with a low recurrence rate.

Materials and methods

Including twenty patients with endometriosis given conservative surgery, a prospective clinical study was performed with randomly grouping and positive control. The traditional Chinese medicine (TCM) and western medicine (WM) groups were given Danchi decoction and GnRH-a or gestrinone respectively. Treatment was given in 1–5 days during the first menstruation. The eutopic endometriums were collected before and 3 months after the treatment, respectively. Then immunohistochemistry was performed to obtain the expressions of P450arom and survivin. In the normal control (NC) group no drugs were administered.

Results

Before the treatment, the expressions of P450arom and survivin in both TCM and WM groups were much higher than the NC group (P0.05). The expressions of the two groups were remarkably decreased after the treatment (P0.05).

Conclusion

Danchi decoction can control the recurrence of endometriosis by restraining abnormal secretion of aromatizing enzyme and regulating cell apoptosis in eutopic endometrium. Excessive expressions of aromatizing enzyme and decreased apoptosis are a possible mechanism of endometriosis recurrence. Key words: Endometriosis, Recurrence, Danchi Decoction, Eutopic endometrium

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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